Herbicidal oxatricyclic ethers

ABSTRACT

This patent application relates to Certain tricyclic ether herbicidal compounds and their use to control a broad spectrum of undesirable plant growth.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a 371 of PCT/US92/03879 filed May 15, 1992 whichapplication is a continuation-in-part of co-pending application U.S.Ser. No. 07/702,997 filed May 20, 1991, now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to certain herbicidal ethers, agriculturallysuitable compositions thereof, and a method for their use as broadspectrum preemergent or postemergent herbicides.

New compounds effective for controlling the growth of undesiredvegetation are in constant demand. In the most common situation, suchcompounds are sought to selectively control the growth of weeds inuseful crops such as cotton, rice, corn, wheat and soybeans, to name afew. Unchecked weed growth in such crops can cause significant losses,reducing profit to the farmer and increasing costs to the consumer. Inother situations, herbicides are desired which will control all plantgrowth. Examples of areas in which complete control of all vegetation isdesired are areas around railroad tracks, storage tanks and industrialstorage areas. There are many products commercially available for thesepurposes, but the search continues for products which are moreeffective, less costly and environmentally safe.

U.S. Pat. No. 4,670,041 discloses herbicidal compounds of the formula:##STR1## wherein, inter alia:

Y is (--CR⁵ R⁶ --)_(n) in which n is 0, 1 or 2; and

R⁵ and R⁶ (in part) form an alkylene group containing 4 or 5 carbonatoms.

U.S. Pat. No. 4,828,603 discloses herbicidal compounds of the formula:##STR2## wherein, inter alia:

X is O, S, NR or CH₂ ; and

Y is (in part) CH₂.

SUMMARY OF THE INVENTION

This invention pertains to compounds of Formulas I through XV includingstereoisomers, suitable compositions containing them and their use asbroad spectrum preemergence and postemergence herbicides ##STR3##wherein:

n is 2, 3 or 4;

m is 3, 4 or 5;

p is 2 or 3;

R¹ is straight chain C₁ -C₃ alkyl;

R² is H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl or C₂ -C₄ alkynyl;

R³ and R⁴ are independently H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl, C₂ -C₄alkynyl or C₁ -C₃ alkyl substituted with OCH₃ or OCH₂ CH₃ ;

R⁵ and R⁶ are independently H, OCH₃ or C₁ -C₂ alkyl;

Q is CH₂ W or ##STR4##

q and r are independently 0-2;

R⁷ is H, halogen, C₁ -C₃ alkyl, OR⁸, SR⁸ or CN;

R⁸ is C₁ -C₃ alkyl or C₁ -C₃ haloalkyl;

Z is CH₂, NR⁹, O, S or may be CH and taken to form a double bond with anadjacent carbon;

R⁹ is H or C₁ -C₃ alkyl;

W is phenyl optionally substituted with 1-3 substituents selected fromhalogen, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, OH, CN, C₁ -C₃ haloalkyl, C₁ -C₃haloalkoxy, C₁ -C₃ alkylthio, C₂ -C₄ alkenyl and C₂ -C₄ alkynyl; or W is5-, 6- or 7-membered heterocyclic ring containing 0-2 nitrogens, 0-2oxygens or 0-2 sulfurs, each ring optionally substituted with 1-2substituents selected from halogen, CH₃ and OCH₃ ;

provided that

1) the sum of q and r is 0-2;

2) if the sum of q and r is 0 then Z is CH₂ ; and

3) if W is a heterocycle then the total number of heteroatoms containedwithin the heterocyclic rings is 3 or less.

Representative examples of the aforementioned heterocycles included inthe definition of W include but are not limited to pyrrole, furan,thiophene, tetrahydropyran, tetrahydrofuran, isoxazole, oxazole,pyrazole, imidazole, thiazole, pyridine and pyrazine.

In the above definitions, the term "alkyl", used either alone or incompound words such as "haloalkyl" or "alkylthio", includes straightchain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or thedifferent butyl isomers.

"Alkoxy", "alkenyl" and "alkynyl" includes straight chain or branchedisomers, e.g., ethoxy, n-propyloxy, isopropyloxy, 1-propenyl, 2-propenyland 3-propenyl.

"Halogen", either alone or in compound words such as "haloalkyl", meansfluorine, chlorine, bromine or iodine. Further, when used in compoundwords such as "haloalkyl" said alkyl may be partially or fullysubstituted with halogen atoms which may be the same or different.Examples of haloalkyl include CH₂ CH₂ F, CF₂ CF₃ and CH₂ CHFCl.

The compounds of the invention which are preferred for either theirbiological activity and/or ease of synthesis are:

1. Compounds of Formulas I, II, III, V or VIII wherein:

W is phenyl optionally substituted by 1-2 substituents selected from F,Cl, Br, CH₃ and OCH₃ ; or W is tetrahydropyran, tetrahydrofuran,thiophene, isoxazole, pyridine or pyrazine, each ring optionallysubstituted with 1-2 substituents selected from F, Cl, Br, CH₃ and OCH₃;

Q is CH₂ W or ##STR5## R⁵ and R⁶ are independently H or C₁ -C₂ alkyl.

2. Compounds of Preferred 1 wherein:

R² is H, C₁ -C₃ alkyl, C₂ -C₃ alkenyl or C₂ -C₃ alkynyl.

3. Compounds of Preferred 2 wherein:

R³ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;

R⁴ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl.

4. Compounds of Preferred 3 wherein:

Q is CH₂ W or Q-1, Q-3, Q-4, Q-6, Q-7, Q-8 or Q-15;

R⁵ and R⁶ are independently H;

W is phenyl optionally substituted with 1-2 substituents selected fromF, Cl, Br and CH₃ ; tetrahydrofuran; thiophene optionally substitutedwith Cl or Br; or pyridine.

5. Compounds of Preferred 4 wherein:

R¹ is CH₃ or CH₂ CH₃ ;

R² is H, CH₃, CH₂ CH₃ or allyl; and

R³ and R⁴ are H.

6. Compounds of Preferred 5 wherein the formula is Formula I.

7. Compounds of Preferred 5 wherein the formula is Formula II.

8. Compounds of Preferred 5 wherein the formula is Formula III.

9. Compounds of Preferred 5 wherein the formula is Formula V.

10. Compounds of Preferred 5 wherein the formula is Formula VIII.

Compounds of the invention which are specifically preferred for theirbiological activity and/or ease of synthesis are the compounds ofPreferred 5 which are:

(2α,3β,4aβ,5α,7aβ)-3-[(2-fluorophenyl)methoxy]octahydro-2,4a-dimethyl-2,5-methanocyclopenta-[b]pyran;

(2α,3β,4a,5α,9aβ)-3-[(2,6-difluorophenyl)methoxy]-decahydro-2-methyl-2,5-methanocyclohepta[b]pyran;

(2α,3β,4a,5α,7β)-3-[(2-fluorophenyl)methoxy]octahydro-2-methyl-2,5-methanocyclopenta[b]pyran;

(2α,3β,4aβ,5α,9aβ)-3l-[(2-fluorophenyl)methoxy]decahydro-2-methyl-2,5-methanocyclohepta[b]pyran;

(2α,3β,4aβ,5α,7aβ)-octahydro-2,4a-dimethyl-3-(phenylmethoxy)-2,5-methanocyclopenta[b]-pyran;

(2α,3β,4aβ,5α,7aβ)-3-[(2-chlorophenyl)methoxy]octahydro-2,4a-dimethyl-2,5-methanocyclopenta-[b]pyran;and

(2α,3β,4aβ,5α,7aβ)-octahydro-2,4a-dimethyl-3-[(2-methylphenyl)methoxy]-2,5-methanocyclopenta[b]pyran.

Compounds of Formula I-XV that have the QO group syn with respect to theoxygen-containing bridge are usually more herbicidally active than theanti form. The present invention contemplates all of the herbicidallyactive forms resulting from synthesis and from deliberately createdmixtures.

Compositions suitable for controlling the growth of undesired vegetationare also contemplated as within the scope of this invention. Suchcompositions comprise an effective amount of any of the compoundsdisclosed herein and at least one of the following: surfactant, soliddiluent or liquid diluent.

Methods for controlling the growth of undesired vegetation are similarlyconsidered to be within the scope of the invention. These methodscomprise applying to the locus to be protected an effective amount ofany of the compounds disclosed herein. Of particular importance is themethod wherein the locus to be protected is rice, corn, soybeans orcereals.

DETAILED DESCRIPTION OF THE INVENTION

The compounds I-XII of the invention are prepared by treating theappropriately substituted oxatricycloalkanol (Ia-XIIa wherein Q is H)with a compound of the formula QX in which X is a halogen atom or amesyloxy or a tosyloxy group or the like. This reaction is carried out,as shown in Scheme 1, in the presence of a strong base, such as analkali metal hydride, in an inert solvent, such as ethers, aromatichydrocarbons, dimethylformamide and the like. Suitable temperatures forthe reaction are preferably from 20° C. to 100° C. The product ethersare recovered and isolated by conventional techniques. ##STR6##

The alkylating agents QX are prepared in the conventional manners knownto those skilled in the art from the alcohols QOH.

The alcohols, QOH, are generally known in the art and are mostconveniently prepared through metal hydride (e.g., sodium borohydride)reduction of the corresponding carbonyl compounds or the correspondingketones which can be derived by Friedel-Crafts type cyclization ofderivatives of phenylalkylcarboxylic acid, phenoxyalkylcarboxylic acids,benzyloxyalkylcarboxylic acids, phenylthioalkylcarboxylic acids, andbenzylthioalkylcarboxylic acids. Details may be found in a) T. Laird inComprehensive Organic Chemistry, D. Barton and W. D. Ollis, ed., Vol. 1,pp. 1165-1168, Pergamon Press, New York (1979); b) M. H. Palmer and N.M. Scollick, J. Chem. Soc. C., (1968), 2833; c) C. E. Dolgliesck andMann, J. Chem. Soc., (1945), 893; d) C. D. Hurd and S. Hayao, J. Am.Chem. Soc., (1954), 76, 4299 and 5056; and e) R. Lesser, Chem. Ber.(1923), 56, 1642.

Alternatively, the compounds of Formulas I-XII may be prepared by thecoupling procedure described in Scheme 2, which is used in cases wherethe standard Williamson ether synthesis proves problematic. Thisprocedure uses a Lewis acidic metal oxide wherein the metal can removethe halide ion by forming an insoluble precipitate. For example, silver(I) oxide can be used and the silver halide is the co-product.Alternative metal oxides that may be used are HgO, CaO, MgO.N,N-Dimethylformamide and ethereal solvents, such as diethyl ether,tetrahydrofuran, dioxane, or 1,2-dimethoxyethane are the preferredsolvents. Other solvents likely to provide good yields include dipolaraprotic solvents like dimethyl sulfoxide, acetone, andN,N'-dimethylpropyleneurea. ##STR7##

The oxatricycloalkanols Ia-XIIa can be obtained generally by the routeshown in Scheme 3. This route comprises epoxidation of unsaturatedbicyclic alkanols Ib-XIIb (Scheme 4) by treatment with a peroxyacid orother epoxidizing agent known in the art, with or without isolation ofthe intermediate epoxyalkanol, and cyclization by treatment with aprotic or Lewis acid in an inert solvent. ##STR8##

The unsaturated bicyclic alkanols Ib-XIIb are generally known in theart. They can be prepared directly or from appropriate aldehydes,ketones or carboxylic acids or esters or the like by methods known inthe art or obvious modifications thereof. ##STR9##

The compounds of XIII-XV of the invention can be prepared by treatingthe appropriately substituted oxabicycloalkanediols XIIIa-XVa with aprotic acid, such as methanesulfonic acid or para-toluenesulfonic acid,or with a Lewis acid, such as aluminum trichloride zinc dichloride, orboron trifluoride, in an inert solvent, such as halogenatedhydrocarbons, aromatic hydrocarbons and the like. Suitable temperaturesfor the reaction are preferably from -78° C. to 100° C. The reaction iscarried out as short in Schemes 5-7 and the product ethers are recoveredand isolated by conventional techniques. ##STR10##

Alternatively, some of the compounds XIII-XV can be prepared from theappropriately substituted halooxatricyclic ethers (XIIIb-XVb, wherein R⁵or R⁶ is Br or I) as shown in Scheme 8. The halogen atom of XIIIb-XVb isreplaced by OCH₃ by treatment with methanol in the presence of a silversalt or by treatment with a metal methoxide in a solvent such asmethanol or N,N-dimethylformamide, optionally in the presence of acatalyst such as a copper salt or a silver salt, or the halogen atom isreplaced by an alkyl group by treatment with a metal alkylcuprate orsimilar reagent in a solvent such as tetrahydrofuran, or the halogenatom is replaced by H by reduction. This reduction can be accomplishedby methods known in the art including treatment with a trialkyltinhydride in an inert solvent such as benzene or toluene in the presenceof a radical initiator such as benzoyl peroxide, preferably attemperatures of 20° C. to 110° C., or treatment with lithium aluminumhydride in an ethereal solvent, such as tetrahydrofuran or1,2-dimethoxyethane, preferably at temperatures of 20° C. to 100° C., ortreatment with hydrogen gas in the presence of a metal catalyst, such asplatinum or palladium, in an inert solvent. ##STR11##

Non-limiting illustrations of the preparation of oxabicycloalkanediolsXIIIa-XVa are shown in Schemes 9 and 10.

The compounds of Formula XIIIa are synthesized as shown in Scheme 9.Readily available haloaryl ethers 1 is subjected to metal-halogenexchange (e.g., by treatment with lithium metal or an alkyllithium)followed by treatment with a haloolefin optionally in the presence of acatalyst such as a cuprous salt to produce adduct 2 (Equation 9a).

Adduct 2 is subjected to the conditions of the Birch reduction (Birch,A. J., Quart Rev. (London) 1950 4 69; Watt, G. W., Chem. Rev. 1950 46318; Birch, A. J.; Smith, M., Quart Rev. (London) 1958 12 17; Caine, D.,Organic Reactions 1976 23 1) followed by mild acid hydrolysis of theintermediate enol ether to produce dienone 3 (Equation 9b ). ##STR12##

Dienone 3 is treated with an appropriate Grignard reagent ororganolithium reagent (R² M) or with a reducing agent (e.g., sodiumborohydride) to produce dienol 4 (Equation 9c).

Dienol 4 is treated with a metal catalyst epoxidizing reagent known inthe art (e.g., tert-butylhydroperoxide catalyzed by vanadylacetylacetonate) followed by acid-catalyzed cyclization to producehydroxyoxabicycloalkene 5 (Equation 9d).

Compound 5 is treated with ozone followed by reductive work-up (e.g.,with methyl disulfide) or with osmium tetroxide and sodium periodate toproduce aldehyde 6 (or the corresponding hemiacetal) (Equation 9e).

Aldehyde 6 is treated with two equivalents of a Grignard reagent (WMgX)or of an organolithium reagent (WLi) to produce oxabicycloalkanediolXIIIa (Equation 9f).

The compounds of Formula IVa are synthesized as shown in Scheme 10.

Dienone 3 is homologated (e.g., with a Wittig reagent) to producealdehyde 7 (Equation 10a).

Aldehyde 7 is optionally converted to the corresponding ester by methodsknown in the art and optionally alkylated at the α-position using analkylating agent (R² X) and general methods known in the art, thentreated with organometallic reagents (R³ M, R⁴ M) or with a reducingagent (e.g., lithium aluminum hydride) to produce dienol 8 (Equation10b).

Dienol 8 is treated using the methods (or modifications thereof)described in Equations 9d-9f to produce oxabicycloalkanediol XIVa(Equations 10c-10e). ##STR13##

A non-limiting illustration of the preparation of halooxatricyclicethers XIIIb-XVb is shown in Scheme 11. Carbonyl compound 11 (6, whereR¹⁰ is R⁵ and p is p-1) is treated with a Witting reagent to producehydroxyoxabicycloalkene 12 (Equation 11a).

Treatment of intermediate 12 with a source of electrophilic halogen suchas bromine or N-halosuccinimide in the presence of an acid catalystproduces halooxatricyclic ether XIIIb (Equation 11b). ##STR14##

Alternatively, oxatricycloalkanediols XIIIa, where p is 3, can besynthesized as shown in Scheme 12.

Oxatricycloalkenones 13 are available by methods, or modificationsthereof, known in the art. (See Keay, B. A., J. Chem. Soc. Chem Comm.1987 419; DeClercq, P. J.; Van Royen, L. A., Synth. Comm. 1979, 9, 771.)Treatment of compound 13 with hydrogen gas in the presence of a metalcatalyst produces oxatricycloalkanone 14 (Equation 12a).

Treatment of ketone 14 with a peroxyacid under conditions of theBaeyer-Villiger reaction (Hassal, C. W., Organic Reactions 1957 9 73;Lee, S. B.; Uff, B.C., Quart. Rev. Chem. Soc. 1967 21 429) produceslactone 15 (Equation 12b).

Treatment of lactone 15 with one equivalent of a reducing agent such asdi-iso-butylaluminum hydride produces hydroxyaldehyde 16 (Equation 12c).

Treatment of hydroxyaldehyde 16 with at least two equivalents of aGrignard reagent (WMgX) or an organolithium reagent (WLi) producesoxatricycloalkanediol XIIIa (p is 3) (Equation 12d). ##STR15##

The following examples represent the preparation of typical species ofthe invention. The examples are for illustration and should not beregarded as limiting the invention in any way.

EXAMPLE 1(±)-(2α,3β,4aβ,5α,7aβ)-Octahydro-2,4a-dimethyl-3-(phenylmethoxy)-2,5-methanocyclopenta[b]pyran

Step A:(±)-(1α,3aβ,7aβ)-2,3,3a4,7,7a-hexahydro-5,7a-dimethyl-1H-inden-1-ol

A solution of 0.82 g (5.0 mmol) ofcis-2,3,3a,4,7,7a-hexahydro-5,7a-dimethyl-1H-inden-1-one (for asynthesis see Finguelli, F., et al., J. Org. Chem. 1982 47 5056-5064) in5 mL of ethanol was added dropwise to a suspension of 0.38 g (10 mmol)of sodium borohydride in 5 mL of ethanol maintained at 0°-5° C. Themixture was stirred for 1 h at 0° C., then it was poured into 50 mL ofsaturated aqueous ammonium chloride solution and extracted twice with 50mL of diethyl ether. The combined organic extracts were dried overMgSO₄, filtered, and the solvent removed in vacuo to afford the titlecompound (0.58 g, 70%), which crystallized to form a white solid, m.p.60°-69° C. ¹ H NMR: δ 0.96 (s, 3H), 1.4-1.8 (m, 6H), 1.64 (s, 3H), 2.0-2.1 (m, 2H), 2.15 (br, 1H), 3.76 (t, 1H), 5.54 (m, 1H). ¹³ C NMR: δ22.8, 23.4, 26.4, 26.9, 29.6, 30.2, 40.3, 40.6, 82.0, 118.0, 130.3.

Step B:(±)-(1aα,2aα,3β,5aα,6aα)-octahydro-2a,6a-dimethyl-3H-indeno[5.6-b]oxiran-3-ol

A solution of(±)-1α,3aβ,7aβ)-2,3,3a,4,7,7a-hexahydro-5,7a-dimethyl-1H-inden-1-ol (82mmol) in 160 mL dichloromethane was cooled to 0° C. Vanadylacetylacetonate (0.43 g, 1.6 mmol) was added, followed by 90% tert-butylhydroperoxide (13.6 mL, 122 mmol). The cooling bath was removed and themixture was stirred for 2 h. The mixture was again cooled to 0° C. and160 mL of a 10% aqueous solution of sodium sulfite was added dropwise at0°-10° C. This two-phase mixture was stirred for 30 min at 0° C., thenthe organic layer was separated and the aqueous layer was extracted with50 mL of dichloromethane. The organic layers were combined, washed with100 mL of a saturated aqueous solution of sodium bicarbonate, dried overMgSO₄, faltered, and the solvent evaporated in vacuo. Flashchromatography yielded a residue, which was triturated with hexanes toafford the title compound (4.36 g, 29% ) as a white powder, m.p. 83°-85°C. ¹ NMR: δ 0.96 (s, 3H), 1.32 (s, 3H), 1.5-2.0 (m, 8H), 2.30 (dd, 1H),3.03 (m, 1H), 3.09 (d, 1H), 3.55 (m, 1H).

Step C:(±)-(2α,3β,4aβ,5α,7aβ)-octahydro-2,4a-dimethyl-2,5-methanocyclopenta[b]pyran-3-ol

The product of Step B (4.00 g, 22 mmol) was dissolved in 50 mL ofdichloromethane. Camphorsulfonic acid (0.36 g, 1.5 mmol) was added andthe mixture was stirred overnight at room temperature. The reactionmixture was then poured into 100 mL of diethyl ether, washed with asaturated aqueous solution of sodium bicarbonate, dried over MgSO₄,filtered, and the solvent evaporated in vacuo. The residue was subjectedto flash chromatography to afford the title compound (1.56 g, 39%) as acolorless oil. ¹ H NMR: δ 0.77 (s, 3H), 1.10 (s, 3H), 1.4-2.2 (m, 9H),3.44 (dd, 1H), 3.8 (m, 2H).

Step D:(2α,3β,4aβ,5α,7aβ)-octahydro-2,4a-dimethyl-3-(phenylmethoxy)-2,5-methanocyclopenta[b]pyran

0.12 grams of a sodium hydride 60% dispersion in oil (3.0 mmol), waswashed with hexanes, then suspended in 4 mL of dry THF and the mixturewas cooled to 0° C. 0.36 g (2.0 mmol) of the product from Step C wasdissolved in 4 mL THF and then added dropwise at 0°-5° C. The mixturewas stirred at 0° C. for 30 min, then 0.28 mL of benzyl bromide (2.4mmol) and 0.03 grams of potassium iodide (0.2 mmol) were added and themixture was refluxed for 4 hours. The mixture was cooled, 0.2 mL of2-propanol was added, then the mixture was poured into 20 grams of iceand 20 mL of 1.0N hydrochloric acid and extracted into 40 mL ofdichloromethane followed by two 20 mL extractions. The combined organiclayers were dried over MgSO₄, filtered, and the solvent evaporated invacuo. Flash chromatography afforded the title compound (0.28 g, 52%) asa colorless oil. ¹ H NMR: δ 0.78 (s, 3H), 1.12 (s, 3H), 1.38 (d, 1H),1.48 (dd, 1H), 1.6-2.1 (m, 7H), 3.19 (dd, 1H), 3.86 (m, 1H), 4.48 (d,1H), 4.73 (d, 1H), 7.2-7.4 (m, 5H).

EXAMPLE 2(±)-(5aα,8α,9a,β)-8-Ethyloctahydro-2-(2-methylphenyl)-5a,8-epoxy-6H-1-benzoxepin

Step A:(±)-(2α,4aα,8aβ)-2-ethylhexahydro-2H-2,4a-epoxynaphthalen-8(7H)-one

To a solution of 10.84 grams of(±)-(2α,4aα,8aβ)-2-ethyl-1,5,6,8a-tetrahydro-2H-2,4a-epoxynaphthalen-8(7H)-one(synthesized by modification of the methods described by Keay in J.Chem. Soc. Chem. Comm. 1987 419 and by DeClercq and VanRoyen in Synth.Comm. 1979 9 771, starting with 2-ethylfuran) in 225 mL of ethanol wasadded 3.4 grams of 5% palladium on carbon. The mixture was treated withhydrogen gas overnight at room temperature and atmospheric pressure. Thecatalyst was then filtered off, rinsed with ethanol, and the solvent wasevaporated in vacuo to afford the title compound (10.24 g, 93%) as anoil. ¹ H NMR: δ 0.96 (t, 3H), 1.5-1.9 (m, 7H), 1.9-2.1 (m, 3H), 2.1-2.3(m, 3H), 2.45 (m 2H).

Step B:(±)-(5aα,8α,9aβ)-8-ethylhexahydro-6H-5a,8-epoxy-1-benzoxepin-2(3H)-one

The product of Step A was dissolved in 350 mL of dichloromethane and27.5 grams of 50% meta-chloroperoxybenzoic acid (1.5 equivalents) wasadded. The mixture was stirred for 3 days, then 35 mL of a 10% aqueoussolution of sodium hydrogen sulfite was added dropwise with cooling tomaintain the temperature of the mixture below 30° C. The mixture wasstirred for 30 min, then 900 mL dichloromethane was added and theorganic layer was separated, washed with 260 mL of a 1.0N solution ofsodium hydroxide, dried over MgSO₄ and filtered. The solvent wasevaporated in vacuo to afford the title compound (11.08 g, 100%) as alight yellow oil. ¹ H NMR: δ 1.00 (t, 3H), 1.5-2.2 (m, 12H), 2.6-2.9 (m,2H), 4.50 (dd, 1H).

Step C: (±)-exo-4-ethyl-2-hydroxy-7-oxabicyclo[2.2.1]heptane-1-butanal

A portion of the product of Step B (2.10 g, 10 mmol) was dissolved in 40mL of toluene. The solution was cooled to -70° C., then 10 mL of adiisobutylaluminum hydride solution (1.5M solution in toluene, 15 mmol)was added dropwise, maintaining the temperature below -60° C. Thereaction mixture was stirred for 1 hour at -70° C., then transferred viacannula to a stirred mixture of 50 grams of ice, 40 mL of water and 10mL of acetic acid. This mixture was stirred for 5 min, then extractedwith two 50 mL portions of diethyl ether. The combined ether layers werewashed with 50 mL of water, then with 50 mL of saturated aqueous sodiumbicarbonate solution. All of the aqueous layers were combined, saturatedwith sodium chloride, and extracted with three 50 mL portions ofdichloromethane. The dichloromethane layers were combined and washedwith two 50 mL portions of saturated aqueous sodium bicarbonatesolution. All of the organic layers were dried over MgSO₄ and filtered,and the solvents were removed in vacuo to afford the title compound(1.30 g, 61%) as an oil. Due to equilibration between aldehyde anddiastereomeric lactol forms, complete spectral characterization of thetitle compound was difficult. ¹ H NMR (inter alia): δ 0.97 (t), 9.77(s).

Step D:(±)-exo-4-ethyl-2-hydroxy-α-(2-methylphenyl)-7-oxabicyclo[2.2.1]heptane-1-butanol

The product of Step C was dissolved in 15 mL of diethyl ether and thesolution was cooled to 0° C. Then 8 mL of a solution ofortho-tolylmagnesium bromide (2 M solution, 16 mmol) was added dropwise,maintaining the temperature of the reaction mixture at 0°-5=C. Themixture was stirred for 1 hour at 0° C., then 2 mL of additionalortho-tolylmagnesium bromide (2 M solution, 4 mmol) was added dropwiseat 0°-5° C. The mixture was stirred for 40 min at 0° C., then 10 mL of asaturated aqueous solution of ammonium chloride was added dropwise.Water and diethyl ether were added to dissolve solids, the organic layerwas separated, and the aqueous layer was extracted with 20 mL of diethylether. The combined organic layers were washed with a saturated aqueoussolution of sodium bicarbonate, dried over MgSO₄ and faltered. Thesolvent was removed in vacuo and the solid residue was triturated withhexanes to afford the title compound (1.19 g, 64%) as a white solid,m.p. 108°-119° C. ¹ H NMR: δ 0.97 (t, 3H), 1.3-2.2 (m, 15H), 2.33 (s,3H), 3.88 (m, 1H), 4.97 (m, 1H), 7.1-7.3 (m, 3H), 7.48 (d, 1H).

Step E:(±)-(5aα,8α,9aβ)-8-ethyloctahydro-2-(2-methylphenyl)-5a,8-epoxy-6H-1-benzoxepin

A portion of the product of Step D (0.46 g, 1.5 mmol) and 0.21 grams ofzinc chloride (1.5 mmol) were combined in 30 mL of dichloromethane andthe mixture was refluxed for 5 hours. The mixture was then cooled,diluted with 60 mL of dichloromethane, and washed with 30 mL of water,then with a saturated aqueous solution of 30 mL of sodium bicarbonate.The organic layer was dried over MgSO₄ and filtered and the solvent wasremoved in vacuo. The residue was subjected to flash chromatography onsilica gel to afford the less polar diastereomer of the title compound(0.06 g, 14%) as an oil, followed by the more polar diastereomer of thetitle compound (0.10 g, 23%) as an oil. ¹ H NMR (less polardiastereomer): δ 1.03 (t, 3H), 1.5-1.8 (m, 7H), 1.8-2.0 (m, 5H), 2.12(m, 2H), 2.31 (s, 3H), 4.12 (m, 1H), 5.07 (d, 1H), 7.10 (m, 2H), 7.18(t, 1H), 7.42 (d, 1H). ¹ H NMR (more polar diastereomer): δ 0.98 (t,3H), 1.4-1.6 (m, 5H), 1.7-1.9 (m, 4H), 1.9-2.1 (m, 2H), 2.1-2.2 (m, 2H),2.24 (m, 1H), 2.31 (s, 3H), 3.89 (m, 1H), 4.52 (d, 1H), 7.1-7.2 (m, 3H),7.51 (d, 1H).

By the general procedures described in Schemes 1-12 and Examples 1-2, orby obvious modifications thereof, the compounds of Tables 1-15 can beprepared. ##STR16##

                                      TABLE 1                                     __________________________________________________________________________    Q          n      Q             n                                             __________________________________________________________________________    General Structure 1, R.sup.5 = R.sup.6 is H, R.sup.1 is CH.sub.3              CH.sub.2 (C.sub.6 H.sub.5)                                                               2      CH.sub.2 (2-tetrahydrofuranyl)                                                              2                                             CH.sub.2 (2-FC.sub.6 H.sub.4)                                                            2      CH.sub.2 (2-tetrahydropyranyl)                                                              2                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            2      Q-1           2                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            2      Q-3           2                                             CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   2      Q-4           2                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   2      Q-6           2                                             CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                   2      Q-7           2                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                   2      Q-8           2                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 2      Q-15          2                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                           2      CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              2                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           2      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     2                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           2      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          2                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  2      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     2                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   2      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            2                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   2      CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      2                                             CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                   2      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     2                                             CH.sub.2 (2-pyridyl)                                                                     2      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     2                                             CH.sub.2 (2-thienyl)                                                                     2      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               2                                             CH.sub.2 (2-furanyl)                                                                     2      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      2                                             CH.sub.2 (C.sub.6 H.sub.5)                                                               3      CH.sub.2 (2-tetrahydrofuranyl)                                                              3                                             CH.sub.2 (2-FC.sub.6 H.sub.4)                                                            3      CH.sub.2 (2-tetrahydropyranyl)                                                              3                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            3      Q-1           3                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            3      Q-3           3                                             CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-4           3                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-6           3                                             CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-7           3                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-8           3                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 3      Q-15          3                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              3                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     3                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          3                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  3      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            3                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      3                                             CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-pyridyl)                                                                     3      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-thienyl)                                                                     3      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               3                                             CH.sub.2 (2-furanyl)                                                                     3      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      3                                             CH.sub.2 (C.sub.6 H.sub.5)                                                               4      CH.sub.2 (2-tetrahydrofuranyl)                                                              4                                             CH.sub.2 (2-FC.sub. 6 H.sub.4)                                                           4      CH.sub.2 (2-tetrahydropyranyl)                                                              4                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            4      Q-1           4                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            4      Q-3           4                                             CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   4      Q-4           4                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   4      Q-6           4                                             CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                   4      Q-7           4                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                   4      Q-8           4                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 4      Q-15          4                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                           4      CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              4                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           4      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     4                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           4      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          4                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  4      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     4                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   4      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            4                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   4      CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      4                                             CH.sub.2 (4-(CH.sub. 3)C.sub.6 H.sub.4)                                                  4      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     4                                             CH.sub.2 (2-pyridyl)                                                                     4      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     4                                             CH.sub.2 (2-thienyl)                                                                     4      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               4                                             CH.sub.2 (2-furanyl)                                                                     4      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      4                                             General Structure 1, R.sup.5 = R.sup.6 is H, R.sup.1 is                       CH.sub.2 CH.sub.3                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                               3      CH.sub.2 (2-tetrahydrofuranyl)                                                              3                                             CH.sub.2 (2-FC.sub.6 H.sub.4)                                                            3      CH.sub.2 (2-tetrahydropyranyl)                                                              3                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            3      Q-1           3                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            3      Q-3                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-4           3                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-6           3                                             CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-7           3                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-8           3                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 3      Q-15          3                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-BrC.sub. 6 H.sub.4)                                                             3                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     3                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          3                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  3      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            3                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      3                                             CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-pyridyl)                                                                     3      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-thienyl)                                                                     3      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               3                                             CH.sub.2 (2-furanyl)                                                                     3      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      3                                             General Structure 1, R.sup.5 is OCH.sub.3, R.sup.6 is H, R.sup.1 is           CH.sub.3                                                                      CH.sub.2 (C.sub.6 H.sub.5)                                                               3      CH.sub.2 (2-tetrahydrofuranyl)                                                              3                                             CH.sub.2 (2-FC.sub.6 H.sub.4)                                                            3      CH.sub.2 (2-tetrahydropyranyl)                                                              3                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            3      Q-1           3                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            3      Q-3                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-4           3                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-6           3                                             CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-7           3                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-8           3                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 3      Q-15          3                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              3                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     3                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          3                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  3      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            3                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      3                                             CH.sub.2 (4-(CH.sub. 3)C.sub.6 H.sub.4)                                                  3      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-pyridyl)                                                                     3      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-thienyl)                                                                     3      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               3                                             CH.sub.2 (2-furanyl)                                                                     3      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      3                                             __________________________________________________________________________

                                      TABLE 2                                     __________________________________________________________________________    Q          n      Q             n                                             __________________________________________________________________________    General Structure 2, R.sup.5 = R.sup.6 is H, R.sup.2 is CH.sub.3              CH.sub.2 (C.sub.6 H.sub.5)                                                               2      CH.sub.2 (2-tetrahydrofuranyl)                                                              2                                             CH.sub.2 (2-FC.sub.6 H.sub.4)                                                            2      CH.sub.2 (2-tetrahydropyranyl)                                                              2                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            2      Q-1           2                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            2      Q-3           2                                             CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   2      Q-4           2                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   2      Q-6           2                                             CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                   2      Q-7           2                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                   2      Q-8           2                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 2      Q-15          2                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                           2      CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              2                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           2      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     2                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           2      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          2                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  2      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     2                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   2      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            2                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   2      CH.sub.2 (2-CF.sub.3)C.sub.6 H.sub.4)                                                       2                                             CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                   2      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     2                                             CH.sub.2 (2-pyridyl)                                                                     2      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     2                                             CH.sub.2 (2-thienyl)                                                                     2      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               2                                             CH.sub.2 (2-furanyl)                                                                     2      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      2                                             CH.sub.2 (C.sub.6 H.sub.5)                                                               3      CH.sub.2 (2-tetrahydrofuranyl)                                                              3                                             CH.sub.2 (2-FC.sub.6 H.sub.4)                                                            3      CH.sub.2 (2-tetrahydropyranyl)                                                              3                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            3      Q-1           3                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            3      Q-3           3                                             CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-4           3                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-6           3                                             CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-7           3                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-8           3                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 3      Q-15          3                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              3                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     3                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          3                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  3      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            3                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      3                                             CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-pyridyl)                                                                     3      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-thienyl)                                                                     3      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               3                                             CH.sub.2 (2-furanyl)                                                                     3      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      3                                             General Structure 2, R.sup.5 = R.sup.6 is H, R.sup.2 is                       CH.sub.2 CH.sub.3                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                               3      CH.sub.2 (2-tetrahydrofuranyl)                                                              3                                             CH.sub.2 (2-FC.sub.6 H.sub.4)                                                            3      CH.sub.2 (2-tetrahydropyranyl)                                                              3                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            3      Q-1           3                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            3      Q-3           3                                             CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-4           3                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-6           3                                             CH.sub.2 (2-5-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-7           3                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-8           3                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 3      Q-15          3                                             CH.sub.2 (2,ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              3                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     3                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          3                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  3      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            3                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      3                                             CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-pyridyl)                                                                     3      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-thienyl)                                                                     3      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               3                                             CH.sub.2 (2-furanyl)                                                                     3      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      3                                             General Structure 2, R.sup.5 is OCH.sub.3, R.sup.6 is H, R.sup.2 is           CH.sub.3                                                                      CH.sub.2 (C.sub.6 H.sub.5)                                                               3      CH.sub.2 (2-tetrahydrofuranyl)                                                              3                                             CH.sub.2 (2-FC.sub.6 H.sub.4)                                                            3      CH.sub.2 (2-tetrahydropyranyl)                                                              3                                             CH.sub.2 (3-FC.sub.6 H.sub.4)                                                            3      Q-1           3                                             CH.sub.2 (4-FC.sub.6 H.sub.4)                                                            3      Q-3           3                                             CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-4           3                                             CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-6           3                                             CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                   3      Q-7           3                                             CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub. 3)                                                  3      Q-8           3                                             CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                 3      Q-15          3                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              3                                             CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     3                                             CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                           3      CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          3                                             CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                  3      CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            3                                             CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      3                                             CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                   3      CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-pyridyl)                                                                     3      CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     3                                             CH.sub.2 (2-thienyl)                                                                     3      CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               3                                             CH.sub.2 (2-furanyl)                                                                     3      CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                      3                                             __________________________________________________________________________

                                      TABLE 3                                     __________________________________________________________________________    Q         R.sup.3 Q            R.sup.3                                        __________________________________________________________________________    General Structure 3, n is 2, R.sup.1 is CH.sub.3, R.sup.2 is H                CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3 )                                                H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3 )                                                 CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═ CH.sub.2)C.sub.6 H.sub.4)                                             CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 3, n is 2, R.sup.1 is CH.sub.3, R.sup.2 is CH.sub.3         CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub. 4)                                                 H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub. 6 H.sub.4)                                                         CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub. 3                   CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 3, n is 3, R.sup.1 is CH.sub.3, R.sup.2 is H                CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub. 6 H.sub.4)                                                          H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub. 2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                   H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub. 6 H.sub.4)                                                         CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)CH.sub.6 H.sub.4)                                                          CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub. 3)                                                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub. 2 CH═CH.sub.2                                                             CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 3, n is 3, R.sup.1 is CH.sub.3, R.sup.2 is CH.sub.3         CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub. 2 CH.sub.2 OCH.sub.3                   CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 3, n is 4, R.sup.1 is CH.sub.3, R.sup.2 is H                CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub. 4)                                                    CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2-6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub. 3                                                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 3, n is 4, R.sup.1 is CH.sub.3, R.sup.2 is CH.sub.3         CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3 )                                                 CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub. 6 H.sub.4)                                                   CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    __________________________________________________________________________

                                      TABLE 4                                     __________________________________________________________________________    Q               R.sup.2                                                                           Q             R.sup.2                                     __________________________________________________________________________    General Structure 4, m is 3, R.sup.3 ═R.sup.4 is H                        CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                                    CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyranyl)                                                              CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-1           CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-3           CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-4           CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-6           CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-7           CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-8           CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub. 3                                                                         Q-15          CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      CH.sub.3                                                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       CH.sub.3                                                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                                CH.sub.3                                                       General Structure 4, m is 3, R.sup.3 ═R.sup.4 is CH.sup.3                CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                                    CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyranyl)                                                              CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-1           CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-3           CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-4           CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-6           CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-7           CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-8           CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-15          CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      CH.sub. 3                                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       CH.sub.3                                                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                                CH.sub.3                                                      General Structure 4, m is 4, R.sup.3 ═R.sup.4 is H                        CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.                                                        H)                                          CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                                    CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyranyl)                                                              CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-1           CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-3           CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-4           CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-6           CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-7           CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-8           CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-15          CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      CH.sub.3                                                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub. 4)                                                               CH.sub.3                                                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       CH.sub.3                                                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                                CH.sub.3                                                      General Structure 4, m is 4, R.sup.3 ═R.sup.4 is CH.sub.3                 CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub. 2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                                    CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyranyl)                                                              CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-1           CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-3           CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-4           CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-6           CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-7           CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-8           CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-15          CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      CH.sub.3                                                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     CH.sub. 3                                   CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       CH.sub.3                                                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                                CH.sub.3                                                      General Structure 4, m is 5, R.sup.3 ═R.sup.4 is H                        CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             __________________________________________________________________________

                                      TABLE 5                                     __________________________________________________________________________    Q            R.sup.1                                                                            Q            R.sup.1                                        __________________________________________________________________________    General Structure 5, m is 3, R.sup.3 ═R.sup.4 is H                        CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-1          CH.sub.2 CH.sub.3                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-3          CH.sub.2 CH.sub.3                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-4          CH.sub.2 CH.sub. 3                             CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-6          CH.sub.2 CH.sub.3                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-7          CH.sub.2 CH.sub.3                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-8          CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-15         CH.sub.2 CH.sub.3                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.3                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-thienyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.2 CH.sub.3                              CH.sub.2 (2-furanyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.2 CH.sub.3                                                General Structure 5, m is 3, R.sup.3 ═R.sup.4 is CH.sup.3                 CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub. 6 H.sub.3)                                                    CH.sub.3                                                                           Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-1          CH.sub.2 CH.sub.3                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-3          CH.sub.2 CH.sub.3                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-4          CH.sub.2 CH.sub.3                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-6          CH.sub.2 CH.sub.3                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-7          CH.sub.2 CH.sub.3                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-8          CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-15         CH.sub.2 CH.sub.3                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-ClC.sub.6 H.sub.4 )                                                            CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.3                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-thienyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.2 CH.sub.3                              CH.sub.2 (2-furanyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.2 CH.sub.3                                                General Structure 5, m is 4, R.sup.3 ═R.sup.4 is CH.sub.3                 CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub. 3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-1          CH.sub.2 CH.sub.3                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-3          CH.sub.2 CH.sub.3                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-4          CH.sub.2 CH.sub.3                              CH.sub.2 (2,3-F.sub.2 C.sub. 6 H.sub.3)                                                    CH.sub.2 CH.sub.3                                                                  Q-6          CH.sub.2 CH.sub.3                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-7          CH.sub.2 CH.sub.3                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-8          CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-15         CH.sub.2 CH.sub.3                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.3                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-thienyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.2 CH.sub.3                              CH.sub.2 (2-furanyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.2 CH.sub.3                                                General Structure 5, m is 4, R.sup.3 ═R.sup.4 is CH.sub.3                 CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub. 6 H.sub.4)                                             CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-1          CH.sub.2 CH.sub.3                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-3          CH.sub.2 CH.sub.3                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.3                                                                  Q-4          CH.sub.2 CH.sub.3                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-6          CH.sub.2 CH.sub.3                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-7          CH.sub.2 CH.sub.3                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-8          CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                  Q-15         CH.sub.2 CH.sub.3                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub. 2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                   CH.sub.2 CH.sub.3                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.3                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-thienyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.2 CH.sub.3                              CH.sub.2 (2-furanyl)                                                                       CH.sub.2 CH.sub.3                                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.2 CH.sub. 3                                               General Structure 5, m is 5, R.sup.3 ═R.sup.4 is CH.sub.3                 CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                   CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                             CH.sub.3                                                                           CH.sub.2 (2-(OCH.sub.3)C.sub. 6 H.sub.4)                                                   CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                       CH.sub.3                                                                           CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                                         __________________________________________________________________________

                                      TABLE 6                                     __________________________________________________________________________    Q               R.sup.2                                                                           Q             R.sup.2                                     __________________________________________________________________________    General Structure 6, m is 3, R.sup.1 is CH.sub.3                              CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3 )                                                      H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                                    CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyranyl)                                                              CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-1           CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-3           CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-4           CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-6           CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-7           CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-8           CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-15          CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      CH.sub.3                                                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       CH.sub.3                                                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                                CH.sub.3                                                      General Structure 6, m is 3, R.sup.1 is CH.sub.2 CH.sup.3                     CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub. 6 H.sub.4)                                                       H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                                    CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyranyl)                                                              CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-1           CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-3           CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-4           CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-6           CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-7           CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-8           CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-15          CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      CH.sub.3                                                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       CH.sub.3                                                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                                CH.sub.3                                                      General Structure 6, m is 4, R.sup.1 is CH.sub.3                              CH.sub.2 (C.sub. 6 H.sub.5)                                                                   H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                                    CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyranyl)                                                              CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-1           CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-3           CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-4           CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-6           CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-7           CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-8           CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-15          CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      CH.sub.3                                                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub. 2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       CH.sub.3                                                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                                CH.sub.3                                                      General Structure 6, m is 4, R.sup.1 is CH.sub.2 CH.sub.3                     CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub. 6 H.sub.4)                                                                H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.                                                       H)                                          CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             CH.sub.2 (C.sub.6 H.sub.5)                                                                    CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyranyl)                                                              CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-1           CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-3           CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 CH.sub.3                                                                          Q-4           CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-6           CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-7           CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-8           CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        CH.sub.3                                                                          Q-15          CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      CH.sub.3                                                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub. 4)                                                               CH.sub.3                                                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                CH.sub.3                                                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       CH.sub.3                                                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        CH.sub.3                                                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                          CH.sub.3                                                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                                CH.sub.3                                                      General Structure 6, m is 5, R.sup.1 is CH.sub.3                              CH.sub.2 (C.sub.6 H.sub.5)                                                                    H   CH.sub.2 (2-tetrahydropyranyl)                                                              H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                 H   Q-1           H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                 H   Q-3           H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                 H   Q-4           H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-6           H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-7           H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-8           H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                        H   Q-15          H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                      H   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                              H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                     H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                          H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                H   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                       H   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                        H   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-pyridyl)                                                                          H   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                     H                                           CH.sub.2 (2-thienyl)                                                                          H   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                               H                                           CH.sub.2 (2-furanyl)                                                                          H   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                                H                                                             __________________________________________________________________________

                                      TABLE 7                                     __________________________________________________________________________    Q         R.sup.3 Q            R.sup.3                                        __________________________________________________________________________    General Structure 7, n in 2, R.sup.1 is CH.sub.3, R.sup.2 is H                CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3 )                                                H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrhydropyranyl)                                                              CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3 )                                                 CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-CH═ CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2,Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub. 2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                   CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       General Structure 7, n is 2, R.sup.1 is CH.sub.3, R.sup.2 is CH.sub.3         CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub. 5)                                                                CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 7, n is 3, R.sup.1 is CH.sub.3, R.sup.2 is H                CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4 )                                                          H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3 )C.sub.6 H.sub.4)                                                   H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4 )                                                         CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.tbd.CH                                                             CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 7, n is 3, R.sup.1 is CH.sub.3, R.sup.2 is CH.sub.3         CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-CH.sub.3)C.sub.6 H.sub.4)                                                   H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub. 4)                                                 CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub. 6 H.sub.3)                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub. 3)C.sub.6 H.sub.4)                                                 CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 7, n is 4, R.sup.1 is CH.sub.3, R.sup.2 is H                CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4                                                     H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.3)                                                             CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub. 4)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 C.tbd.CH                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub. 3                   Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    General Structure 7, n is 4, R.sup.1 is CH.sub.3, R.sup.2 is CH.sub.3         CH.sub.2 (C.sub.6 H.sub.5)                                                              H       CH.sub.2 (2-tetrahydrofuranyl)                                                             H                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           H       CH.sub.2 (2-tetrahydropyranyl)                                                             H                                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           H       Q-1          H                                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           H       Q-3          H                                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-4          H                                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-6          H                                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-7          H                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  H       Q-8          H                                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                H       Q-15         H                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             H                                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    H                                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          H       CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         H                                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub. 3)                                                H       CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           H                                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  H       CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-pyridyl)                                                                    H       CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    H                                              CH.sub.2 (2-thienyl)                                                                    H       CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              H                                              CH.sub.2 (2-furanyl)                                                                    H       CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     H                                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydrofuranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub. 3)                                                 CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (C.sub.6 H.sub.5)                                                                 CH.sub.2 C.tbd.CH                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 C.tbd.CH                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 C.tbd.CH                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 (2,Cl-6-FC.sub.6 H.sub.3)                                                    CH.sub.2 .tbd.CH                                            CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 C.tbd.CH                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 C.tbd.CH                              Q-1       CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 C.tbd.CH                              CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (C.sub. 6 H.sub.5)                                                                CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                              CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                      CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.2 OCH.sub.3                    CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH═CH.sub.2                                                              CH.sub.2 (2-pyridyl)                                                                       CH.sub.2 CH.sub.2 OCH.sub.3                    Q-1       CH.sub.2 CH═CH.sub.2                                                              Q-1          CH.sub.2 CH.sub.2 OCH.sub.3                    __________________________________________________________________________

                                      TABLE 8                                     __________________________________________________________________________    Q             R.sup.2                                                                            Q              R.sup.2                                     __________________________________________________________________________    General Structure 8, m is 3, R.sup.3 = R.sup.4 is H                           CH.sub.2 (C.sub.6 H.sub.5)                                                                  H    CH.sub.2 (2-tetrahydropyranyl)                                                               H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               H    Q-1            H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               H    Q-3            H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               H    Q-4            H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-6            H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-7            H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-8            H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-15           H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    H    CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                           H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     H    CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                             H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-pyridyl)                                                                        H    CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-thienyl)                                                                        H    CH.sub.2 (2-CH═CH.sub.2)C.sub.6 H.sub.4)                                                 H                                           CH.sub.2 (2-furanyl)                                                                        H    CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                              H                                                               CH.sub.2 (C.sub.6 H.sub.5)                                                                  CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                               CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-1            CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-3            CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-4            CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-6            CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-7            CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-8            CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3 )                                                     CH.sub.3                                                                           Q-15           CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                           CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                             CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                       CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                       CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                              CH.sub. 3                                                       General Structure 8, m is 3, R.sup.3 = R.sup.4 is CH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                                  H    CH.sub.2 (2-tetrahydropyranyl)                                                               H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               H    Q-1            H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               H    Q-3            H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               H    Q-4            H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-6            H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-7            H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-8            H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-15           H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    H    CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2,Cl-6-FC.sub.6 H.sub.3)                                                           H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     H    CH.sub.2 (2-(CN)C.sub.6 H.sub.4 )                                                            H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-pyridyl)                                                                        H    CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-thienyl)                                                                        H    CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                H                                           CH.sub.2 (2-furanyl)                                                                        H    CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                              H                                                               CH.sub.2 (C.sub.6 H.sub.5)                                                                  CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                               CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-1            CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-3            CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-4            CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-6            CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-7            CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-8            CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-15           CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                           CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                             CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                       CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                        CH.sub.3                                                                           CH.sub.2 (C.tbd.CH)C.sub.6 H.sub.4)                                                          CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                              CH.sub.3                                                        General Structure 8, m is 4, R.sup.3  = R.sup.4 is H                          CH.sub.2 (C.sub.6 H.sub.5)                                                                  H    CH.sub.2 (2-tetrahydropyranyl)                                                               H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               H    Q-1            H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               H    Q-3            H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               H    Q-4            H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-6            H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-7            H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-8            H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-15           H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    H    CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                           H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     H    CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                             H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub. 2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-pyridyl)                                                                        H    CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-thienyl)                                                                        H    CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                H                                           CH.sub.2 (2-furanyl)                                                                        H    CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                              H                                                               CH.sub.2 (C.sub.6 H.sub.5)                                                                  CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                               CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-1            CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-3            CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-4            CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-6            CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-7            CH.sub.3                                    CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-8            CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-15           CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               CH.sub. 3                                   CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                           CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                             CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                       CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                       CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                              CH.sub.3                                                        General Structure 8, m is 4, R.sup.3 = R.sup.4 is CH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                                  H    CH.sub.2 (2-tetrahydropyranyl)                                                               H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               H    Q-1            H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               H    Q-3            H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               H    Q-4            H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-6            H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-7            H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-8            H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-15           H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    H    CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                           H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     H    CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                             H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (3-(CH.sub. 3)C.sub.6 H.sub.4)                                                     H    CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-pyridyl)                                                                        H    CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-thienyl)                                                                        H    CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                H                                           CH.sub.2 (2-furanyl)                                                                        H    CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                              H                                                               CH.sub.2 (C.sub.6 H.sub.5)                                                                  CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyranyl)                                                               CH.sub.3                                    CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-1            CH.sub.3                                    CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-3            CH.sub.3                                    CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               CH.sub.3                                                                           Q-4            CH.sub.3                                    CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-6            CH.sub.3                                    CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-7            CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-8            CH.sub.3                                    CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                                                           Q-15           CH.sub.3                                    CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    CH.sub.3                                                                           CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               CH.sub.3                                    CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      CH.sub.3                                    CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                           CH.sub.3                                    CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              CH.sub.3                                                                           CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     CH.sub.3                                                                           CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                             CH.sub.3                                    CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                                                           CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                       CH.sub.3                                    CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                                                           CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-pyridyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      CH.sub.3                                    CH.sub.2 (2-thienyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                CH.sub.3                                    CH.sub.2 (2-furanyl)                                                                        CH.sub.3                                                                           CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                       CH.sub.3                                    CH.sub.2 (2-tetrahydrofuranyl)                                                              CH.sub.3                                                        General Structure 8, m is 5, R.sup.3 = R.sup.4 is H                           CH.sub.2 (C.sub.6 H.sub.5)                                                                  H    CH.sub.2 (2-tetrahydropyranyl)                                                               H                                           CH.sub.2 (2-FC.sub.6 H.sub.4)                                                               H    Q-1            H                                           CH.sub.2 (3-FC.sub.6 H.sub.4)                                                               H    Q-3            H                                           CH.sub.2 (4-FC.sub.6 H.sub.4)                                                               H    Q-4            H                                           CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-6            H                                           CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-7            H                                           CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-8            H                                           CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                      H    Q-15           H                                           CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                    H    CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                               H                                           CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                      H                                           CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                           H                                           CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                              H    CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                     H    CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                             H                                           CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                      H    CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-pyridyl)                                                                        H    CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                      H                                           CH.sub.2 (2-thienyl)                                                                        H    CH.sub.2 (2-CH═CH.sub.2)C.sub.6 H.sub.4)                                                 H                                           CH.sub.2 (2-furanyl)                                                                        H    CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                       H                                           CH.sub.2 (2-tetrahydrofuranyl)                                                              H                                                               __________________________________________________________________________

                                      TABLE 9                                     __________________________________________________________________________    Q         R.sup.1 Q            R.sup.1                                        __________________________________________________________________________    General Structure 9, m is 3, R.sup.3 = R.sup.4 is H                           CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (CH.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                          CH.sub.3                                                            CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 CH.sub.3                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-3          CH.sub.2 CH.sub.3                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-4          CH.sub.2 CH.sub.3                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-6          CH.sub.2 CH.sub.3                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-7          CH.sub.2 CH.sub.3                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-8          CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-15         CH.sub.2 CH.sub.3                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.3                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4 )                                                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-thienyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.2 CH.sub.3                              CH.sub.2 (2-furanyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (2-tetrahydrofuranyl)                                                          CH.sub.2 CH.sub.3                                                   General Structure 9, m is 3, R.sup.3 = R.sup.4 is CH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                          CH.sub.3                                                            CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 CH.sub.3                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-3          CH.sub.2 CH.sub.3                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-4          CH.sub.2 CH.sub.3                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-6          CH.sub.2 CH.sub.3                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-7          CH.sub.2 CH.sub.3                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-8          CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-15         CH.sub.2 CH.sub.3                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-ClC.sub. 6 H.sub.4)                                                         CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-thienyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.2 CH.sub.3                              CH.sub.2 (2-furanyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub. 2 CH.sub.3                             CH.sub.2 (2-tetrahydroduranyl)                                                          CH.sub.2 CH.sub.3                                                   General Structure 9, m is 4, R.sup.3 = R.sup.4 is H                           CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                          CH.sub.3                                                            CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 CH.sub.3                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-3          CH.sub.2 CH.sub.3                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-4          CH.sub.2 CH.sub.3                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-6          CH.sub.2 CH.sub.3                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-7          CH.sub.2 CH.sub.3                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-8          CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-15         CH.sub.2 CH.sub.3                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.3                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub. 3                                                                    CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-thienyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.2 CH.sub.3                              CH.sub.2 (2-furanyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (2-tetrahydrofuranyl)                                                          CH.sub.2 CH.sub.3                                                   General Structure 9, m is 4, R.sup.3 = R.sup.4 is CH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub. 2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                             CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                          CH.sub.3                                                            CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-1          CH.sub.2 CH.sub.3                              CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-3          CH.sub.2 CH.sub.3                              CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                                                     Q-4          CH.sub.2 CH.sub.3                              CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-6          CH.sub.2 CH.sub.3                              CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-7          CH.sub.2 CH.sub.3                              CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-8          CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.2 CH.sub.3                                                                     Q-15         CH.sub.2 CH.sub.3                              CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.2 CH.sub.3                              CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.2 CH.sub.3                              CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                              CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-pyridyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                              CH.sub.2 (2-thienyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.2 CH.sub.3                              CH.sub.2 (2-furanyl)                                                                    CH.sub.2 CH.sub.3                                                                     CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.2 CH.sub.3                              CH.sub. 2 (2-tetrahydrofuranyl)                                                         CH.sub.2 CH.sub.3                                                   General Structure 9, m is 5, R.sup.3 = R.sup.4 is H                           CH.sub.2 (C.sub.6 H.sub.5)                                                              CH.sub.3                                                                              CH.sub.2 (2-tetrahydropyranyl)                                                             CH.sub.3                                       CH.sub.2 (2-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-1          CH.sub.3                                       CH.sub.2 (3-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-3          CH.sub.3                                       CH.sub.2 (4-FC.sub.6 H.sub.4)                                                           CH.sub.3                                                                              Q-4          CH.sub.3                                       CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-6          CH.sub.3                                       CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-7          CH.sub.3                                       CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-8          CH.sub.3                                       CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                  CH.sub.3                                                                              Q-15         CH.sub.3                                       CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                CH.sub.3                                                                              CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                             CH.sub.3                                       CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                    CH.sub.3                                       CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                          CH.sub.3                                                                              CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                         CH.sub.3                                       CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                          CH.sub. 3                                                                             CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                 CH.sub.3                                                                              CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                           CH.sub.3                                       CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                  CH.sub.3                                                                              CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-pyridyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                    CH.sub.3                                       CH.sub.2 (2-thienyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                              CH.sub.3                                       CH.sub.2 (2-furanyl)                                                                    CH.sub.3                                                                              CH.sub.2 (2-(C.tbd.CH)C.sub.6 H.sub.4)                                                     CH.sub.3                                       CH.sub.2 (2-tetrahydrofuranyl)                                                          CH.sub.3                                                            __________________________________________________________________________

                  TABLE 10                                                        ______________________________________                                        Q                   R.sup.3                                                   ______________________________________                                        General Structure 10, m is 3, R.sup.1 is CH.sub.3                             CH.sub.2 (C.sub.6 H.sub.5)                                                                        H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                        CH.sub.3                                                  CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          CH.sub.3                                                  CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (3-ClC.sub.6 H.sub. 4)                                                                   CH.sub.3                                                  CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-pyridyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-thienyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-tetrahydrofuranyl)                                                                    CH.sub.3                                                  CH.sub.2 (2-tetrahydropyranyl)                                                                    CH.sub.3                                                  Q-1                 CH.sub.3                                                  Q-3                 CH.sub.3                                                  Q-4                 CH.sub.3                                                  Q-6                 CH.sub.3                                                  Q-7                 CH.sub.3                                                  Q-8                 CH.sub.3                                                  Q-15                CH.sub.3                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                CH.sub.3                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  CH.sub.3                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     CH.sub.3                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  General Structure 10, m is 3, R.sup.1 is CH.sub.2 CH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                                        H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                        CH.sub.3                                                  CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          CH.sub.3                                                  CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub. 2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                  CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-pyridyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-thienyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-tetrahydrofuranyl)                                                                    CH.sub.3                                                  CH.sub.2 (2-tetrahydropyranyl)                                                                    CH.sub.3                                                  Q-1                 CH.sub.3                                                  Q-3                 CH.sub.3                                                  Q-4                 CH.sub.3                                                  Q-6                 CH.sub.3                                                  Q-7                 CH.sub.3                                                  Q-8                 CH.sub.3                                                  Q-15                CH.sub.3                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                CH.sub.3                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  CH.sub.3                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     CH.sub.3                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  General Structure 10, m is 4, R.sup.1 is CH.sub.3                             CH.sub.2 (C.sub.6 H.sub.5)                                                                        H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub. 2 C.sub.6 H.sub.3)                                                          H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                        CH.sub.3                                                  CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          CH.sub.3                                                  CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    CH.sub. 3                                                 CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-pyridyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-thienyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-tetrahydrofuranyl)                                                                    CH.sub.3                                                  CH.sub.2 (2-tetrahydropyranyl)                                                                    CH.sub.3                                                  Q-1                 CH.sub.3                                                  Q-3                 CH.sub.3                                                  Q-4                 CH.sub.3                                                  Q-6                 CH.sub.3                                                  Q-7                 CH.sub.3                                                  Q-8                 CH.sub.3                                                  Q-15                CH.sub.3                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                CH.sub.3                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  CH.sub.3                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     CH.sub.3                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  General Structure 10, m is 4, R.sup.1 is CH.sub.2 CH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                                        H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3 )                                                          H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                        CH.sub.3                                                  CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          CH.sub.3                                                  CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-pyridyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-thienyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-tetrahydrofuranyl)                                                                    CH.sub.3                                                  CH.sub.2 (2-tetrahydropyranyl)                                                                    CH.sub.3                                                  Q-1                 CH.sub.3                                                  Q-3                 CH.sub.3                                                  Q-4                 CH.sub.3                                                  Q-6                 CH.sub.3                                                  Q-7                 CH.sub.3                                                  Q-8                 CH.sub.3                                                  Q-15                CH.sub.3                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                CH.sub.3                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  CH.sub.3                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     CH.sub.3                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  General Structure 10, m is 5, R.sup.1 is CH.sub.3                              CH.sub.2 (C.sub.6 H.sub.5)                                                                       H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub. 3)                                                               H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         ______________________________________                                    

                  TABLE 11                                                        ______________________________________                                        Q                   R.sup.3                                                   ______________________________________                                        General Structure 11, n is 2, R.sup.1 is CH.sub.3                             CH.sub.2 (C.sub.6 H.sub.5)                                                                        H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                        CH.sub.3                                                  CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          CH.sub.3                                                  CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (3-ClC.sub.6 H.sub. 4)                                                                   CH.sub.3                                                  CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-pyridyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-thienyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-tetrahydrofuranyl)                                                                    CH.sub.3                                                  CH.sub.2 (2-tetrahydropyranyl)                                                                    CH.sub.3                                                  Q-1                 CH.sub.3                                                  Q-3                 CH.sub.3                                                  Q-4                 CH.sub.3                                                  Q-6                 CH.sub.3                                                  Q-7                 CH.sub.3                                                  Q-8                 CH.sub.3                                                  Q-15                CH.sub.3                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                CH.sub.3                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  CH.sub.3                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     CH.sub.3                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  General Structure 11, n is 2, R.sup.1 is CH.sub.2 CH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                                        H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                        CH.sub.3                                                  CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          CH.sub.3                                                  CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub. 2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                  CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-pyridyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-thienyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-tetrahydrofuranyl)                                                                    CH.sub.3                                                  CH.sub.2 (2-tetrahydropyranyl)                                                                    CH.sub.3                                                  Q-1                 CH.sub.3                                                  Q-3                 CH.sub.3                                                  Q-4                 CH.sub.3                                                  Q-6                 CH.sub.3                                                  Q-7                 CH.sub.3                                                  Q-8                 CH.sub.3                                                  Q-15                CH.sub.3                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                CH.sub.3                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  CH.sub.3                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     CH.sub.3                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  General Structure 11, n is 3, R.sup.1 is CH.sub.3                             CH.sub.2 (C.sub.6 H.sub.5)                                                                        H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub. 2 C.sub.6 H.sub.3)                                                          H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                        CH.sub.3                                                  CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          CH.sub.3                                                  CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    CH.sub. 3                                                 CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-pyridyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-thienyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-tetrahydrofuranyl)                                                                    CH.sub.3                                                  CH.sub.2 (2-tetrahydropyranyl)                                                                    CH.sub.3                                                  Q-1                 CH.sub.3                                                  Q-3                 CH.sub.3                                                  Q-4                 CH.sub.3                                                  Q-6                 CH.sub.3                                                  Q-7                 CH.sub.3                                                  Q-8                 CH.sub.3                                                  Q-15                CH.sub.3                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                CH.sub.3                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  CH.sub.3                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     CH.sub.3                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  General Structure 11, n is 3, R.sup.1 is CH.sub.2 CH.sub.3                    CH.sub.2 (C.sub.6 H.sub.5)                                                                        H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3 )                                                          H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (C.sub.6 H.sub.5)                                                                        CH.sub.3                                                  CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     CH.sub.3                                                  CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            CH.sub.3                                                  CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          CH.sub.3                                                  CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-pyridyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-thienyl)                                                                              CH.sub.3                                                  CH.sub.2 (2-tetrahydrofuranyl)                                                                    CH.sub.3                                                  CH.sub.2 (2-tetrahydropyranyl)                                                                    CH.sub.3                                                  Q-1                 CH.sub.3                                                  Q-3                 CH.sub.3                                                  Q-4                 CH.sub.3                                                  Q-6                 CH.sub.3                                                  Q-7                 CH.sub.3                                                  Q-8                 CH.sub.3                                                  Q-15                CH.sub.3                                                  CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    CH.sub.3                                                  CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                  CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                                CH.sub.3                                                  CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  CH.sub.3                                                  CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                  CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     CH.sub.3                                                  CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            CH.sub.3                                                  General Structure 11, n is 4, R.sup.1 is CH.sub.3                              CH.sub.2 (C.sub.6 H.sub.5)                                                                       H                                                         CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                     H                                                         CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                            H                                                         CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                          H                                                         CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-pyridyl)                                                                              H                                                         CH.sub.2 (2-thienyl)                                                                              H                                                         CH.sub.2 (2-tetrahydrofuranyl)                                                                    H                                                         CH.sub.2 (2-tetrahydropyranyl)                                                                    H                                                         Q-1                 H                                                         Q-3                 H                                                         Q-4                 H                                                         Q-6                 H                                                         Q-7                 H                                                         Q-8                 H                                                         Q-15                H                                                         CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                    H                                                         CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                           H                                                         CH.sub.2 (2-Cl-6-FC.sub.6 H.sub. 3)                                                               H                                                         CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                  H                                                         CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                            H                                                         CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                           H                                                         CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                     H                                                         CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                            H                                                         ______________________________________                                    

                  TABLE 12                                                        ______________________________________                                        Q                  R.sup.1                                                    ______________________________________                                        General Structure 12, m is 3, R.sup.3 ═R.sup.4 is H                       CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.3                                                   CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.3                                                   CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-pyridyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-thienyl)                                                                             CH.sub.3                                                   CH.sub. 2 (2-tetrahydrofuranyl)                                                                  CH.sub.3                                                   CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.3                                                   Q-1                CH.sub.3                                                   Q-3                CH.sub.3                                                   Q-4                CH.sub.3                                                   Q-6                CH.sub.3                                                   Q-7                CH.sub.3                                                   Q-8                CH.sub.3                                                   Q-15               CH.sub.3                                                   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.3                                                   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.3                                                   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                    CH.sub.3                                                   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.2 CH.sub.3                                          CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.2 CH.sub.3                                          CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2-pyridyl)                                                                             CH.sub.2 CH.sub.3                                          CH.sub.2 (2-thienyl)                                                                             CH.sub.2 CH.sub.3                                          CH.sub.2 (2-tetrahydrofuranyl)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.2 CH.sub.3                                          Q-1                CH.sub.2 CH.sub.3                                          Q-3                CH.sub.2 CH.sub.3                                          Q-4                CH.sub.2 CH.sub.3                                          Q-6                CH.sub.2 CH.sub.3                                          Q-7                CH.sub.2 CH.sub.3                                          Q-8                CH.sub.2 CH.sub.3                                          Q-15               CH.sub.2 CH.sub.3                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          General Structure 12, m is 3, R.sup.3 ═R.sup.4 is CH.sub.3                CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.3                                                   CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3 )                                                          CH.sub.3                                                   CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.3                                                   CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-pyridyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-thienyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-tetrahydrofuranyl)                                                                   CH.sub.3                                                   CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.3                                                   Q-1                CH.sub.3                                                   Q-3                CH.sub.3                                                   Q-4                CH.sub.3                                                   Q-6                CH.sub.3                                                   Q-7                CH.sub.3                                                   Q-8                CH.sub.3                                                   Q-15               CH.sub.3                                                   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.3                                                   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.3                                                   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-(OCF.sub. 3)C.sub.6 H.sub.4)                                                         CH.sub.3                                                   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                    CH.sub.3                                                   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.2 CH.sub.3                                          CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.2 CH.sub.3                                          CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CH.sub.3 )C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2-pyridyl)                                                                             CH.sub.2 CH.sub.3                                          CH.sub.2 (2-thienyl)                                                                             CH.sub.2 CH.sub.3                                          CH.sub.2 (2-tetrahydrofuranyl)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.2 CH.sub.3                                          Q-1                CH.sub.2 CH.sub.3                                          Q-3                CH.sub.2 CH.sub.3                                          Q-4                CH.sub.2 CH.sub.3                                          Q-6                CH.sub.2 CH.sub.3                                          Q-7                CH.sub.2 CH.sub.3                                          Q-8                CH.sub.2 CH.sub.3                                          Q-15               CH.sub.2 CH.sub.3                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CH═CH.sub. 2)C.sub.6 H.sub.4)                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          General Structure 12, m is 4, R.sup.3 ═R.sup.4 is H                       CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.3                                                   CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.3                                                   CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-pyridyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-thienyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-tetrahydrofuranyl)                                                                   CH.sub.3                                                   CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.3                                                   Q-1                CH.sub.3                                                   Q-3                CH.sub.3                                                   Q-4                CH.sub.3                                                   Q-6                CH.sub.3                                                   Q-7                CH.sub.3                                                   Q-8                CH.sub.3                                                   Q-15               CH.sub.3                                                   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.3                                                   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.3                                                   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                    CH.sub.3                                                   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.2 CH.sub.3                                          CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.2 CH.sub.3                                          CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2-pyridyl)                                                                             CH.sub.2 CH.sub.3                                          CH.sub.2 (2-thienyl)                                                                             CH.sub.2 CH.sub.3                                          CH.sub.2 (2-tetrahydrofuranyl)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.2 CH.sub.3                                          Q-1                CH.sub.2 CH.sub.3                                          Q-3                CH.sub.2 CH.sub.3                                          Q-4                CH.sub.2 CH.sub.3                                          Q-6                CH.sub.2 CH.sub.3                                          Q-7                CH.sub.2 CH.sub.3                                          Q-8                CH.sub.2 CH.sub.3                                          Q-15               CH.sub.2 CH.sub.3                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          General Structure 12, m is 4, R.sup.3 ═R.sup.4 is CH.sub.3                CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.3                                                   CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.3                                                   CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-pyridyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-thienyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-tetrahydrofuranyl)                                                                   CH.sub.3                                                   CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.3                                                   Q-1                CH.sub.3                                                   Q-3                CH.sub.3                                                   Q-4                CH.sub.3                                                   Q-6                CH.sub.3                                                   Q-7                CH.sub.3                                                   Q-8                CH.sub.3                                                   Q-15               CH.sub.3                                                   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.3                                                   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.3                                                   CH.sub. 2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                    CH.sub.3                                                   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.2 CH.sub.3                                          CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.2 CH.sub.3                                          CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2-pyridyl)                                                                             CH.sub.2 CH.sub.3                                          CH.sub.2 (2-thienyl)                                                                             CH.sub.2 CH.sub.3                                          CH.sub.2 (2-tetrahydrofuranyl)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.2 CH.sub.3                                          Q-1                CH.sub.2 CH.sub.3                                          Q-3                CH.sub.2 CH.sub.3                                          Q-4                CH.sub.2 CH.sub.3                                          Q-6                CH.sub.2 CH.sub.3                                          Q-7                CH.sub.2 CH.sub.3                                          Q-8                CH.sub.2 CH.sub.3                                          Q-15               CH.sub.2 CH.sub.3                                          CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.2 CH.sub.3                                          CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(SCH.sub.3 )C.sub.6 H.sub.4)                                                         CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                    CH.sub.2 CH.sub.3                                          CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.2 CH.sub.3                                          General Structure 12, m is 5, R.sup.3 ═R.sup.4 is H                       CH.sub.2 (C.sub.6 H.sub.5)                                                                       CH.sub.3                                                   CH.sub.2 (2-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (3-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (4-FC.sub.6 H.sub.4)                                                                    CH.sub.3                                                   CH.sub.2 (2,3-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,5-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,6-F.sub.2 C.sub.6 H.sub.3)                                                           CH.sub.3                                                   CH.sub.2 (2,4,6-F.sub.3 C.sub.6 H.sub.2)                                                         CH.sub.3                                                   CH.sub.2 (2-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (3-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (4-ClC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Cl.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (3-(CH.sub.3)C.sub.6 H.sub. 4)                                                          CH.sub.3                                                   CH.sub.2 (4-(CH.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-pyridyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-thienyl)                                                                             CH.sub.3                                                   CH.sub.2 (2-tetrahydrofuranyl)                                                                   CH.sub.3                                                   CH.sub.2 (2-tetrahydropyranyl)                                                                   CH.sub.3                                                   Q-1                CH.sub.3                                                   Q-3                CH.sub.3                                                   Q-4                CH.sub.3                                                   Q-6                CH.sub.3                                                   Q-7                CH.sub.3                                                   Q-8                CH.sub.3                                                   Q-15               CH.sub.3                                                   CH.sub.2 (2-BrC.sub.6 H.sub.4)                                                                   CH.sub.3                                                   CH.sub.2 (2,6-Br.sub.2 C.sub.6 H.sub.3)                                                          CH.sub.3                                                   CH.sub.2 (2-Cl-6-FC.sub.6 H.sub.3)                                                               CH.sub.3                                                   CH.sub.2 (2-(OCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CN)C.sub.6 H.sub.4)                                                                 CH.sub.3                                                   CH.sub.2 (2-(CF.sub.3)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   CH.sub.2 (2-(OCF.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(SCH.sub.3)C.sub.6 H.sub.4)                                                          CH.sub.3                                                   CH.sub.2 (2-(CH═CH.sub.2)C.sub.6 H.sub.4)                                                    CH.sub.3                                                   CH.sub.2 (2-(C═CH)C.sub.6 H.sub.4)                                                           CH.sub.3                                                   ______________________________________                                    

                  TABLE 13                                                        ______________________________________                                        General Structure 13, p is 2                                                  W            R.sup.2 W              R.sup.2                                   ______________________________________                                        C.sub.6 H.sub.5                                                                            CH.sub.3                                                                              C.sub.6 H.sub.5                                                                              CH.sub.2 CH.sub.3                         2-FC.sub.6 H.sub.4                                                                         CH.sub.3                                                                              2-FC.sub.6 H.sub.4                                                                           CH.sub.2 CH.sub.3                         3-FC.sub.6 H.sub.4                                                                         CH.sub.3                                                                              2-FC.sub.6 H.sub.4                                                                           CH.sub.2 CH.sub.3                         4-FC.sub.6 H.sub.4                                                                         CH.sub.3                                                                              4-FC.sub.6 H.sub.4                                                                           CH.sub.2 CH.sub.3                         2,3-F.sub.2 C.sub.6 H.sub.3                                                                CH.sub.3                                                                              2,3-F.sub.2 C.sub.6 H.sub.3                                                                  CH.sub.2 CH.sub.3                         2,4-F.sub.2 C.sub.6 H.sub.3                                                                CH.sub.3                                                                              2,4-F.sub.2 C.sub.6 H.sub.3                                                                  CH.sub.2 CH.sub.3                         2,5-F.sub.2 C.sub.6 H.sub.3                                                                CH.sub.3                                                                              2,5-F.sub.2 C.sub.6 H.sub.3                                                                  CH.sub.2 CH.sub.3                         2,4,6-F.sub.3 C.sub.6 H.sub.2                                                              CH.sub.3                                                                              2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                CH.sub.2 CH.sub.3                         2-ClC.sub.6 H.sub.4                                                                        CH.sub.3                                                                              2-ClC.sub.6 H.sub.4                                                                          CH.sub.2 CH.sub.3                         2-Cl-6-FC.sub.6 H.sub.3                                                                    CH.sub.3                                                                              2-Cl-6-FC.sub.6 H.sub.3                                                                      CH.sub.2 CH.sub.3                         2-(CH.sub.3)C.sub.6 H.sub.4                                                                CH.sub.3                                                                              2-(CH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.2 CH.sub.3                         2-pyridyl    CH.sub.3                                                                              2-pyridyl      CH.sub.2 CH.sub.3                         2-thienyl    CH.sub.3                                                                              2-thienyl      CH.sub.2 CH.sub.3                         2-tetrahydrofuranyl                                                                        CH.sub.3                                                                              2-tetrahydrofuranyl                                                                          CH.sub.2 CH.sub.3                         2-(OCH.sub.3)C.sub.6 H.sub.4                                                               CH.sub.3                                                                              2-(OCH.sub.3)C.sub.6 H.sub.4                                                                 CH.sub.2 CH.sub.3                         2-(CN)C.sub.6 H.sub.4                                                                      CH.sub.3                                                                              2-(CN)C.sub.6 H.sub.4                                                                        CH.sub.2 CH.sub.3                         2-(CF.sub.3)C.sub.6 H.sub.4                                                                CH.sub.3                                                                              2-(CF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.2 CH.sub.3                         2-(OCF.sub.3)C.sub.6 H.sub.4                                                               CH.sub.3                                                                              2-(OCF.sub.3)C.sub.6 H.sub.4                                                                 CH.sub.2 CH.sub.3                         2-(SCH.sub.3)C.sub.6 H.sub.4                                                               CH.sub.3                                                                              2-(SCH.sub.3)C.sub.6 H.sub.4                                                                 CH.sub.2 CH.sub.3                         2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                         CH.sub.3                                                                              2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                           CH.sub.2 CH.sub.3                         2-(C.tbd.CH)C.sub.6 H.sub.4                                                                CH.sub.3                                                                              2-(C.tbd.CH)C.sub.6 H.sub.4                                                                  CH.sub.2 CH.sub.3                         ______________________________________                                        General Structure 13, p is 3                                                  W            R.sup.2 W              R.sup.2                                   ______________________________________                                        C.sub.6 H.sub.5                                                                            CH.sub.3                                                                              C.sub.6 H.sub.5                                                                              CH.sub.2 CH.sub.3                         2-FC.sub.6 H.sub.4                                                                         CH.sub.3                                                                              2-FC.sub.6 H.sub.4                                                                           CH.sub.2 CH.sub.3                         3-FC.sub.6 H.sub.4                                                                         CH.sub.3                                                                              3-FC.sub.6 H.sub.4                                                                           CH.sub.2 CH.sub.3                         4-FC.sub.6 H.sub.4                                                                         CH.sub.3                                                                              4-FC.sub.6 H.sub.4                                                                           CH.sub.2 CH.sub.3                         2,3-F.sub.2 C.sub.6 H.sub.3                                                                CH.sub.3                                                                              2,3-F.sub.2 C.sub.6 H.sub.3                                                                  CH.sub.2 CH.sub.3                         2,4-F.sub.2 C.sub.6 H.sub.3                                                                CH.sub.3                                                                              2,4-F.sub.2 C.sub.6 H.sub.3                                                                  CH.sub.2 CH.sub.3                         2,5-F.sub.2 C.sub.6 H.sub.3                                                                CH.sub.3                                                                              2,5-F.sub.2 C.sub.6 H.sub.3                                                                  CH.sub.2 CH.sub.3                         2,4,6-F.sub.3 C.sub.6 H.sub.2                                                              CH.sub.3                                                                              2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                CH.sub.2 CH.sub.3                         2-ClC.sub.6 H.sub.4                                                                        CH.sub.3                                                                              2-ClC.sub.6 H.sub.4                                                                          CH.sub.2 CH.sub.3                         2-Cl-6-FC.sub.6 H.sub.3                                                                    CH.sub.3                                                                              2-Cl-6-FC.sub.6 H.sub.3                                                                      CH.sub.2 CH.sub.3                         2-(CH.sub.3)C.sub.6 H.sub.4                                                                CH.sub.3                                                                              2-(CH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.2 CH.sub.3                         2-pyridyl    CH.sub.3                                                                              2-pyridyl      CH.sub.2 CH.sub.3                         2-thienyl    CH.sub.3                                                                              2-thienyl      CH.sub.2 CH.sub.3                         2-tetrahydrofuranyl                                                                        CH.sub.3                                                                              2-tetrahydrofuranyl                                                                          CH.sub.2 CH.sub.3                         2-(OCH.sub.3)C.sub.6 H.sub.4                                                               CH.sub.3                                                                              2-(OCH.sub.3)C.sub.6 H.sub.4                                                                 CH.sub.2 CH.sub.3                         2-(CN)C.sub.6 H.sub.4                                                                      CH.sub.3                                                                              2-(CN)C.sub.6 H.sub.4                                                                        CH.sub.2 CH.sub.3                         2-(CF.sub.3)C.sub.6 H.sub.4                                                                CH.sub.3                                                                              2-(CF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.2 CH.sub.3                         2-(OCF.sub.3)C.sub.6 H.sub.4                                                               CH.sub.3                                                                              2-(OCF.sub.3)C.sub.6 H.sub.4                                                                 CH.sub.2 CH.sub.3                         2-(SCH.sub.3)C.sub.6 H.sub.4                                                               CH.sub.3                                                                              2-(SCH.sub.3)C.sub.6 H.sub.4                                                                 CH.sub.2 CH.sub.3                         2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                         CH.sub.3                                                                              2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                           CH.sub.2 CH.sub.3                         2-(C.tbd.CH)C.sub.6 H.sub.4                                                                CH.sub.3                                                                              2-(C.tbd.CH)C.sub.6 H.sub.4                                                                  CH.sub.2 CH.sub.3                         ______________________________________                                    

                  TABLE 14                                                        ______________________________________                                        General Structure 14, R.sup.3 ═R.sup.4 is H, p is 2                       W             R.sup.2                                                                              W               R.sup.2                                  ______________________________________                                        C.sub.6 H.sub.5                                                                             H      C.sub.6 H.sub.5 CH.sub.3                                 2-FC.sub.6 H.sub.4                                                                          H      2-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 3-FC.sub.6 H.sub.4                                                                          H      3-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 4-FC.sub.6 H.sub.4                                                                          H      4-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 2,3-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,3-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,4-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,5-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,5-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4,6-F.sub.3 C.sub.6 H.sub.2                                                               H      2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                 CH.sub.3                                 2-ClC.sub.6 H.sub.4                                                                         H      2-ClC.sub.6 H.sub.4                                                                           CH.sub.3                                 2-Cl-6-FC.sub.6 H.sub.3                                                                     H      2-Cl-6-FC.sub.6 H.sub.3                                                                       CH.sub.3                                 2-(CH.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CH.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-pyridyl     H      2-pyridyl       CH.sub.3                                 2-thienyl     H      2-thienyl       CH.sub.3                                 2-tetrahydrofuranyl                                                                         H      2-tetrahydrofuranyl                                                                           CH.sub.3                                 2-(OCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub. 3                                2-(CN)C.sub.6 H.sub.4                                                                       H      2-(CN)C.sub.6 H.sub.4                                                                         CH.sub.3                                 2-(CF.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CF.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-(OCF.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(SCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(SCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                          H      2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                            CH.sub.3                                 2-(C.tbd.CH)C.sub.6 H.sub.4                                                                 H      2-(C.tbd.CH)C.sub.6 H.sub.4                                                                   CH.sub.3                                 ______________________________________                                        General Structure 14, R.sup.3 ═R.sup.4 is CH.sub.3, p is 2                W             R.sup.2                                                                              W               R.sup.2                                  ______________________________________                                        C.sub.6 H.sub.5                                                                             H      C.sub.6 H.sub.5 CH.sub.3                                 2-FC.sub.6 H.sub.4                                                                          H      2-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 3-FC.sub.6 H.sub.4                                                                          H      3-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 4-FC.sub.6 H.sub.4                                                                          H      4-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 2,3-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,3-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,4-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,5-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,5-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4,6-F.sub.3 C.sub.6 H.sub.2                                                               H      2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                 CH.sub.3                                 2-ClC.sub.6 H.sub.4                                                                         H      2-ClC.sub.6 H.sub.4                                                                           CH.sub.3                                 2-Cl-6-FC.sub.6 H.sub.3                                                                     H      2-Cl-6-FC.sub.6 H.sub.3                                                                       CH.sub.3                                 2-(CH.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CH.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-pyridyl     H      2-pyridyl       CH.sub.3                                 2-thienyl     H      2-thienyl       CH.sub.3                                 2-tetrahydrofuranyl                                                                         H      2-tetrahydrofuranyl                                                                           CH.sub.3                                 2-(OCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CN)C.sub.6 H.sub.4                                                                       H      2-(CN)C.sub.6 H.sub.4                                                                         CH.sub.3                                 2-(CF.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CF.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-(OCF.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(SCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(SCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                          H      2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                            CH.sub.3                                 2-(C.tbd.CH)C.sub.6 H.sub.4                                                                 H      2-(C.tbd.CH)C.sub.6 H.sub.4                                                                   CH.sub.3                                 ______________________________________                                        General Structure 14, R.sup.3 ═R.sup.4 is H, p is 3                       W             R.sup.2                                                                              W               R.sup. 2                                 ______________________________________                                        C.sub.6 H.sub.5                                                                             H      C.sub.6 H.sub.5 CH.sub.3                                 2-FC.sub.6 H.sub.4                                                                          H      2-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 3-FC.sub.6 H.sub.4                                                                          H      3-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 4-FC.sub.6 H.sub.4                                                                          H      4-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 2,3-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,3-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,4-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,5-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,5-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4,6-F.sub.3 C.sub.6 H.sub.2                                                               H      2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                 CH.sub.3                                 2-ClC.sub.6 H.sub.4                                                                         H      2-ClC.sub.6 H.sub.4                                                                           CH.sub.3                                 2-Cl-6-FC.sub.6 H.sub.3                                                                     H      2-Cl-6-FC.sub.6 H.sub.3                                                                       CH.sub.3                                 2-(CH.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CH.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-pyridyl     H      2-pyridyl       CH.sub.3                                 2-thienyl     H      2-thienyl       CH.sub.3                                 2-tetrahydrofuranyl                                                                         H      2-tetrahydrofuranyl                                                                           CH.sub.3                                 2-(OCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CN)C.sub.6 H.sub.4                                                                       H      2-(CN)C.sub.6 H.sub.4                                                                         CH.sub.3                                 2-(CF.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CF.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-(OCF.sub. 3)C.sub.6 H.sub.4                                                               H      2-(OCF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(SCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(SCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                          H      2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                            CH.sub.3                                 2-(C.tbd.CH)C.sub.6 H.sub.4                                                                 H      2-(C.tbd.CH)C.sub.6 H.sub.4                                                                   CH.sub.3                                 ______________________________________                                        General Structure 14, R.sup.3 ═R.sup.4 is CH.sub.3, p is 3                W             R.sup.2                                                                              W               R.sup.2                                  ______________________________________                                        C.sub.6 H.sub.5                                                                             H      C.sub.6 H.sub.5 CH.sub.3                                 2-FC.sub.6 H.sub.4                                                                          H      2-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 3-FC.sub.6 H.sub.4                                                                          H      3-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 4-FC.sub.6 H.sub.4                                                                          H      4-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 2,3-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,3-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,4-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,5-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,5-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4,6-F.sub.3 C.sub.6 H.sub.2                                                               H      2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                 CH.sub.3                                 2-ClC.sub.6 H.sub.4                                                                         H      2-ClC.sub.6 H.sub.4                                                                           CH.sub.3                                 2-Cl-6-FC.sub.6 H.sub.3                                                                     H      2-Cl-6-FC.sub.6 H.sub.3                                                                       CH.sub.3                                 2-(CH.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CH.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-pyridyl     H      2-pyridyl       CH.sub.3                                 2-thienyl     H      2-thienyl       CH.sub.3                                 2-tetrahydrofuranyl                                                                         H      2-tetrahydrofuranyl                                                                           CH.sub.3                                 2-(OCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CN)C.sub.6 H.sub.4                                                                       H      2-(CN)C.sub.6 H.sub.4                                                                         CH.sub.3                                 2-(CF.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CF.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-(OCF.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(SCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(SCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                          H      2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                            CH.sub.3                                 2-(C.tbd.CH)C.sub.6 H.sub.4                                                                 H      2-(C.tbd.CH)C.sub.6 H.sub.4                                                                   CH.sub.3                                 ______________________________________                                    

                  TABLE 15                                                        ______________________________________                                        General Structure 15, R.sup.3 ═R.sup.4 is H, p is 2                       W             R.sup.2                                                                              W               R.sup.2                                  ______________________________________                                        C.sub.6 H.sub.5                                                                             H      C.sub.6 H.sub.5 CH.sub.3                                 2-FC.sub.6 H.sub.4                                                                          H      2-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 3-FC.sub.6 H.sub.4                                                                          H      3-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 4-FC.sub.6 H.sub.4                                                                          H      4-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 2,3-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,3-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,4-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,5-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,5-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4,6-F.sub.3 C.sub.6 H.sub.2                                                               H      2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                 CH.sub.3                                 2-ClC.sub.6 H.sub.4                                                                         H      2-ClC.sub.6 H.sub.4                                                                           CH.sub.3                                 2-Cl-6-FC.sub.6 H.sub.3                                                                     H      2-Cl-6-FC.sub.6 H.sub.3                                                                       CH.sub.3                                 2-(CH.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CH.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-pyridyl     H      2-pyridyl       CH.sub.3                                 2-thienyl     H      2-thienyl       CH.sub.3                                 2-tetrahydrofuranyl                                                                         H      2-tetrahydrofuranyl                                                                           CH.sub.3                                 2-(OCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub. 3                                2-(CN)C.sub.6 H.sub.4                                                                       H      2-(CN)C.sub.6 H.sub.4                                                                         CH.sub.3                                 2-(CF.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CF.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-(OCF.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(SCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(SCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                          H      2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                            CH.sub.3                                 2-(C.tbd.CH)C.sub.6 H.sub.4                                                                 H      2-(C.tbd.CH)C.sub.6 H.sub.4                                                                   CH.sub.3                                 ______________________________________                                        General Structure 15, R.sup.3 ═R.sup.4 is CH.sub.3, p is 2                W             R.sup.2                                                                              W               R.sup.2                                  ______________________________________                                        C.sub.6 H.sub.5                                                                             H      C.sub.6 H.sub.5 CH.sub.3                                 2-FC.sub.6 H.sub.4                                                                          H      2-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 3-FC.sub.6 H.sub.4                                                                          H      3-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 4-FC.sub.6 H.sub.4                                                                          H      4-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 2,3-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,3-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,4-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,5-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,5-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4,6-F.sub.3 C.sub.6 H.sub.2                                                               H      2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                 CH.sub.3                                 2-ClC.sub.6 H.sub.4                                                                         H      2-ClC.sub.6 H.sub.4                                                                           CH.sub.3                                 2-Cl-6-FC.sub.6 H.sub.3                                                                     H      2-Cl-6-FC.sub.6 H.sub.3                                                                       CH.sub.3                                 2-(CH.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CH.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-pyridyl     H      2-pyridyl       CH.sub.3                                 2-thienyl     H      2-thienyl       CH.sub.3                                 2-tetrahydrofuranyl                                                                         H      2-tetrahydrofuranyl                                                                           CH.sub.3                                 2-(OCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CN)C.sub.6 H.sub.4                                                                       H      2-(CN)C.sub.6 H.sub.4                                                                         CH.sub.3                                 2-(CF.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CF.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-(OCF.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(SCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(SCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                          H      2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                            CH.sub.3                                 2-(C.tbd.CH)C.sub.6 H.sub.4                                                                 H      2-(C.tbd.CH)C.sub.6 H.sub.4                                                                   CH.sub.3                                 ______________________________________                                        General Structure 15, R.sup.3 ═R.sup.4 is H, p is 3                       W             R.sup.2                                                                              W               R.sup. 2                                 ______________________________________                                        C.sub.6 H.sub.5                                                                             H      C.sub.6 H.sub.5 CH.sub.3                                 2-FC.sub.6 H.sub.4                                                                          H      2-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 3-FC.sub.6 H.sub.4                                                                          H      3-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 4-FC.sub.6 H.sub.4                                                                          H      4-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 2,3-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,3-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,4-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,5-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,5-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4,6-F.sub.3 C.sub.6 H.sub.2                                                               H      2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                 CH.sub.3                                 2-ClC.sub.6 H.sub.4                                                                         H      2-ClC.sub.6 H.sub.4                                                                           CH.sub.3                                 2-Cl-6-FC.sub.6 H.sub.3                                                                     H      2-Cl-6-FC.sub.6 H.sub.3                                                                       CH.sub.3                                 2-(CH.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CH.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-pyridyl     H      2-pyridyl       CH.sub.3                                 2-thienyl     H      2-thienyl       CH.sub.3                                 2-tetrahydrofuranyl                                                                         H      2-tetrahydrofuranyl                                                                           CH.sub.3                                 2-(OCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CN)C.sub.6 H.sub.4                                                                       H      2-(CN)C.sub.6 H.sub.4                                                                         CH.sub.3                                 2-(CF.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CF.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-(OCF.sub. 3)C.sub.6 H.sub.4                                                               H      2-(OCF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(SCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(SCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                          H      2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                            CH.sub.3                                 2-(C.tbd.CH)C.sub.6 H.sub.4                                                                 H      2-(C.tbd.CH)C.sub.6 H.sub.4                                                                   CH.sub.3                                 ______________________________________                                        General Structure 15, R.sup.3 ═R.sup.4 is CH.sub.3, p is 3                W             R.sup.2                                                                              W               R.sup.2                                  ______________________________________                                        C.sub.6 H.sub.5                                                                             H      C.sub.6 H.sub.5 CH.sub.3                                 2-FC.sub.6 H.sub.4                                                                          H      2-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 3-FC.sub.6 H.sub.4                                                                          H      3-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 4-FC.sub.6 H.sub.4                                                                          H      4-FC.sub.6 H.sub.4                                                                            CH.sub.3                                 2,3-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,3-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,4-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,5-F.sub.2 C.sub.6 H.sub.3                                                                 H      2,5-F.sub.2 C.sub.6 H.sub.3                                                                   CH.sub.3                                 2,4,6-F.sub.3 C.sub.6 H.sub.2                                                               H      2,4,6-F.sub.3 C.sub.6 H.sub.2                                                                 CH.sub.3                                 2-ClC.sub.6 H.sub.4                                                                         H      2-ClC.sub.6 H.sub.4                                                                           CH.sub.3                                 2-Cl-6-FC.sub.6 H.sub.3                                                                     H      2-Cl-6-FC.sub.6 H.sub.3                                                                       CH.sub.3                                 2-(CH.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CH.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-pyridyl     H      2-pyridyl       CH.sub.3                                 2-thienyl     H      2-thienyl       CH.sub.3                                 2-tetrahydrofuranyl                                                                         H      2-tetrahydrofuranyl                                                                           CH.sub.3                                 2-(OCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CN)C.sub.6 H.sub.4                                                                       H      2-(CN)C.sub.6 H.sub.4                                                                         CH.sub.3                                 2-(CF.sub.3)C.sub.6 H.sub.4                                                                 H      2-(CF.sub.3)C.sub.6 H.sub.4                                                                   CH.sub.3                                 2-(OCF.sub.3)C.sub.6 H.sub.4                                                                H      2-(OCF.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(SCH.sub.3)C.sub.6 H.sub.4                                                                H      2-(SCH.sub.3)C.sub.6 H.sub.4                                                                  CH.sub.3                                 2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                          H      2-(CH═CH.sub.2)C.sub.6 H.sub.4                                                            CH.sub.3                                 2-(C.tbd.CH)C.sub.6 H.sub.4                                                                 H      2-(C.tbd.CH)C.sub.6 H.sub.4                                                                   CH.sub.3                                 ______________________________________                                         Formulations

Useful formulations of the compounds of Formula I can be prepared inconventional ways. They include dusts, granules, pellets, solutions,suspensions, emulsions, wettable powders, emulsifiable concentrates andthe like. Many of these my be applied directly to the locus to beprotected. Sprayable formulations can be extended in suitable media andused at spray volumes of from a few liters to several hundred liters perhectare. High strength compositions are primarily used as intermediatesfor further formulation. The formulations, broadly, contain about 0.1%to 99% by weight of active ingredient(s) and at least one of (a) about0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquidinert diluent(s). More specifically, they will contain these ingredientsin the following approximate proportions:

    ______________________________________                                                    Weight Percent*                                                               Active                                                                        Ingredient                                                                            Diluent(s)                                                                              Surfactant(s)                                   ______________________________________                                        Wettable Powders                                                                            20-90      0-74     1-10                                        Oil Suspensions,                                                                             3-50     40-95     0-15                                        Emulsions, Solutions,                                                         (including Emulsifiable                                                       Concentrates)                                                                 Aqueous Suspension                                                                          10-50     40-84     1-20                                        Dusts          1-25     70-99     0-5                                         Granules and Pellets                                                                        0.1-95      5-99.9  0-15                                        High Strength 90-99      0-10     0-2                                         Compositions                                                                  ______________________________________                                         *Active ingredients plus at least one of a surfactant or a diluent equals     100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J., but other solids, either mined or manufactured, may beuse. The more absorptive diluents are preferred for wettable powders andthe denser ones for dusts. Typical liquid diluents and solvents aredescribed in Marsden, "Solvents Guide", 2nd Ed., Interscience, New York,1950. Solubility under 0.1% is preferred for suspension concentrates;solution concentrates are preferably stable against phase separation at0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC PublishingCorp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia ofSurface Active Agents", Chemical Publishing Co., Inc., New York, 1964,list surfactants and recommended uses. All formulations can containminor amounts of additives to reduce foaming, caking, corrosion,microbiological growth, etc.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example,Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made byspraying the active material upon preformed granular carriers or byagglomeration techniques. See J. E. Browning, "Agglomeration", ChemicalEngineering, Dec. 4, 1967, pp. 147ff and "Perry's Chemical Engineer'sHandbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-59ff.

For further information regarding the art of formulation, see forexample:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58,132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, Jun. 23, 1959, Col. 3,line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley & Sons, Inc.,New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., BlackwellScientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwiseindicated.

EXAMPLE A

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        (2α,3β,4β,5α,9aβ)-3-[(2-fluorophenyl)methoxy]-d    ecahydro-                     60%                                             2-methyl-2,5-methanocyclohepta[b]pyran                                        sodium alkylnaphthalenesulfonate                                                                             2%                                             sodium liginsulfonate          2%                                             synthetic amorphous silica    36%                                             ______________________________________                                    

The active ingredient is first sprayed onto the amorphous silica, thenthe ingredients are blended, hammer-milled until all the solids areessentially under 50 microns, reblended, and packaged.

EXAMPLE B

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        (2α,3β,4β,5α,9aβ)-3-[(2-fluorophenyl)methoxy]-d    ecahydro-                     50%                                             2-methyl-2,5-methanocyclohepta[b]pyran                                        sodium alkylnaphthalenesulfonate                                                                             2%                                             low viscosity methyl cellulose                                                                               2%                                             diatomaceous earth            46%                                             ______________________________________                                    

The active ingredient is first sprayed onto the diatomaceous earth, thenthe ingredients are blended, coarsely hammer-milled and then air-milledto produce particles essentially all below 10 microns in diameter. Theproduct is reblended before packaging.

    ______________________________________                                        Granule                                                                       ______________________________________                                        Wettable Powder of Eample B                                                                              5%                                                 attapulgite granules      95%                                                 ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on thesurface of attapulgite granules in a double-cone blender. The granulesare dried and packaged.

EXAMPLE D

    ______________________________________                                        Emulsifiable Concentrate                                                      ______________________________________                                        (2α,3β,4β,5α,9aβ)-3-[(2-fluorophenyl)methoxy]-d    ecahydro-                     40%                                             2-methyl-2,5-methanocyclohepta[b]pyran                                        Atlox 3404F                    3%                                             Atlox 3404F                    3%                                             xylene                        54%                                             ______________________________________                                    

The active ingredient and Atlox emulsifiers are dissolved in thesolvent, filtered and packaged. Atlox 3403F and 3404F are blends ofanionic and ionic emulsifiers from ICI Americas, Inc.

EXAMPLE E

    ______________________________________                                        Low Strength Granule                                                          ______________________________________                                        (2α,3β,4β,5α,9aβ)-3-[(2-fluorophenyl)methoxy]-d    ecahydro-                      5%                                             2-methyl-2,5-methanocyclohepta[b]pyran                                        attapulgite granules          95%                                             (U.S.S. 20-40 mesh)                                                           ______________________________________                                    

The active ingredient is dissolved in a solvent and the solution issprayed upon dedusted granules in double-cone blender. After spraying ofthe solution has been completed, the material is warmed to evaporate thesolvent. The material is allowed to cool and then packaged.

EXAMPLE F

    ______________________________________                                        Low Strength Granule                                                          ______________________________________                                        (2α,3β,4β,5α,9aβ)-3-[(2-fluorophenyl)methoxy]-d    ecahydro-                     50%                                             2-methyl-2,5-methanocyclohepta[b]pyran                                        wetting agent                  1%                                             crude ligninsulfonate salt    10%                                             (containing 5-20% of the natural sugars)                                      attapulgite clay              39%                                             ______________________________________                                    

The ingredients are blended and milled to pass through a 100 meshscreen. This material is then added to a fluid bed granulator, the airflow is adjusted to gently fluidize the material, and a fine spray ofwater is sprayed onto the fluidized material. The fluidization andspraying are continued until granules of the desired size range aremade. the spraying is stopped, but fluidization is continued, optionallywith heat, until the water content is reduced to the desired level,generally less than 1%. The material is then discharged, screened to thedesired size range, generally 14-100 mesh (1410-149 microns), andpackaged for use.

EXAMPLE G

    ______________________________________                                        Concentrated Emulsion                                                         ______________________________________                                        (2α,3β,4β,5α,9aβ)-3-[(2-fluorophenyl)methoxy]-d    ecahydro-                     25%                                             2-methyl-2,5-methanocyclohepta[b]pyran                                        xylene                        25%                                             Atlox 3404F                    5%                                             G1284                          6%                                             ethylene glycol                8%                                             water                         32%                                             ______________________________________                                    

The active ingredient, solvent and emulsifiers are blended together.This solution is added to a mixture of the ethylene glycol and waterwith stirring.

EXAMPLE H

    ______________________________________                                        Solution                                                                      ______________________________________                                        (2α,3β,4β,5α,9aβ)-3-[(2-fluorophenyl)methoxy]-d    ecahydro-                      5%                                             2-methyl-2,5-methanocyclohepta[b]pyran                                        water                         95%                                             ______________________________________                                    

The compound is added directly to the water with stirring to produce thesolution, which may then be packaged for use.

EXAMPLE I

    ______________________________________                                        Dust                                                                          ______________________________________                                        (2α,3β,4β,5α,9aβ)-3-[(2-fluorophenyl)methoxy]-d    ecahydro-                     10%                                             2-methyl-2,5-methanocyclohepta[b]pyran                                        attapulgite                   10%                                             Pyrophyllite                  80%                                             ______________________________________                                    

The active ingredient is sprayed onto the attapulgite and then passedthrough a hammer-mill to produce particles substantially all below 200microns. The ground concentrate is then blended with powderedpyrophyllite until homogeneous.

UTILITY

Test results indicate compounds of this invention are activepostemergence and, in particular, preemergence herbicides. Manycompounds in this invention are useful for the control of selected grassand broadleaf weeds with tolerance to important agronomic crops such asbarley (Hordeum vulgare), corn (Zea mays), cotton (Gossypium hirsutum),rape (Brassica napus), rice (Oryza sativa), sorghum (Sorghum bicolor),soybean (Glycine max), sugar beet (Beta vulgaris), wheat (Triticumaestivum), and to vegetable crops. Grass and broadleaf weed speciescontrolled include, but are not limited to, barnyardgrass (Echinochloacrus-galli), blackgrass (Alopecurus myosuroides), crabgrass (Digitariaspp.), duck salad (Heteranthera limosa), foxtail (Setaria spp.),velvetlead (Afutilon theophrasti), and umbrella sedge (Cyperusdifformis). Several compounds in this invention are particularly usefulfor the control of barnyardgrass and selected broadleaf weeds such asduck salad and umbrella sedge in upland and paddy rice.

Effective rates of application for compounds of this invention aredetermined by a number of factors. These factors include: formulationselected, method of application, amount and type of vegetation present,growing conditions, etc. In general terms, the subject compounds shouldbe applied at rates from 0.01 to 20 kg/ha with a preferred rate range of0.03 to 1 kg/ha. One skilled in the art can easily determine effectiveapplication rates necessary for desired level of weed control.

Compounds of this invention may be used alone or in combination withother commercial herbicides, insecticides, or fungicides. The followinglist exemplifies some of the herbicides suitable for use in mixtures. Acombination of a compound from this invention with one or more of thefollowing herbicides may be particularly useful for weed control.

    ______________________________________                                        Common Name                                                                             Chemical Name                                                       ______________________________________                                        acetochlor                                                                              2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-                                       methylphenyl)acetamide                                              acifluorfen                                                                             5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-                                    nitrobenzoic acid                                                   aclonifen 2-chloro-6-nitro-3-phenoxybenzenamine                               acrolein  2-propenal                                                          alachlor  2-chloro-N-(2,6-diethylphenyl)-N-(methoxy-                                    methyl)acetamide                                                    alloxydim methyl 2,2-dimethyl-4,6-dioxo-5-[1-[(2-propenyl-                              oxy)amino]butylidene]cyclohexanecarboxylate                         ametryn   N-ethyl-N'-(1-methylethyl)-6-(methylthio)-1,3,5-                              triazine-2,4-diamine                                                amitrole  1H-1,2,4-triazol-3-amine                                            AMS       ammonium sulfamate                                                  anilofos  S-[2-[(4-chlorophenyl)(1-methylethyl)amino]-2-                                oxoethyl] O,O-dimethylphosphorodithioate                            asulam    methyl [(4-aminophenyl)sulfonylcarbamate                            atrazine  6-chloro-N-ethyl-N'-(1-methylethyl)-1,3,5-                                    triazin-2,4-diamine                                                 aziprotryne                                                                             4-azido-N-(1-methylethyl)-6-methylthio-1,3,5-                                 triazin-2-amine                                                     azoluron  N-(1-ethyl-1H-pyrazol-5-yl)-N'-phenylurea                           barban    4-chloro-2-butynyl 3-chlorocarbamate                                benazolin 4-chloro-2-oxo-3(2H)-benzothiazoleacetic acid                       benfluralin                                                                             N-butyl-N-ethyl-2,6-dinitro-4-(trifluoromethyl)-                              benzenamine                                                         bensulfuron                                                                             2-[[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]-                                   methylcarbonyl]amino]sulfonyl]methyl]-                                        benzoic acid, methyl ester                                          bensulide O,O-bis(1-methylethyl) S-[2-[(phenylsulfonyl)-                                amino]ethyl]phosphorodithioate                                      bentazon  3-(1-methylethyl)-(1H)-2,1,3-benzothiadiazin-                                 4(3H)-one, 2,2-dioxide                                              benzofluor                                                                              N-[4-(ethylthio)-2-(trifluoromethyl)phenyl]-                                  methanesulfonamide                                                  benzoylprop                                                                             N-benzoyl-N-(3,4-dichlorophenyl)-DL-alanine                         benzthiazuron                                                                           N-2-benzothiazolyl-N'-methylurea                                    bialaphos 4-(hydroxymethylphosphinyl)-L-2-amino-                                        butanoyl-L-alanyl-L-alanine                                         bifenox   methyl 5-(2,4-dichlorophenoxy)-2-nitrobenzoate                      bromacil  5-bromo-6-methyl-3-(1-methylpropyl)-2,4-                                      (1H,3H)pyrimidinedione                                              bromobutide                                                                             (+)2-bromo-3,3-dimethyl-N-(1-methyl-1-phenyl-                                 ethyl)butanamide                                                    bromofenoxim                                                                            3,5-dibromo-4-hydroxybenzaldhyde O-(2,4-                                      dinitrophenyl)oxime                                                 bromoxynil                                                                              3,5-dibromo-4-hydroxybenzonitrile                                   bromuron  N'-(4-bromophenyl)-N,N-dimethylurea                                 buminafos dibutyl [1-(butylamino)cyclohexyl]phosphonate                       butachlor N-(butoxymethyl)-2-chloro-N-(2,6-diethyl-                                     phenyl)acetamide                                                    butamifos O-ethyl O-(5-methyl-2-nitrophenyl)-(1methyl-                                  propyl)phosphoramidothioate                                         buthidazole                                                                             3-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]-4-                            hydroxy-1-methyl-2-imidazolidinone                                  butralin  4-(1,1-dimethylethyl)-N-(1-methylpropyl)-2,6-                                 dinitrobenzenamine                                                  butylate  S-ethyl bis(2-methylpropyl)carbamothioate                           cacodylic acid                                                                          dimethyl arsinic oxide                                              carbetamide                                                                             (R)-N-ethyl-2-[[(phenylamino)carbonyl]oxy]-                                   propanamide                                                         CDAA      2-chloro-N,N-di-2-propenylacetamide                                 CDEC      2-chloroallyl diethyldithiocarbamate                                chlomethoxyfen                                                                          4-(2,4-dichlorophenoxy)-2-methoxy-1-nitro-                                    benzene                                                             chloramben                                                                              3-amino-2,5-dichlorobenzoic acid                                    chlorbromuron                                                                           3-(4-bromo-3-chlorophenyl)-1-methoxy-1-                                       methylurea                                                          chlorbufam                                                                              1-methyl-2-propynl(3-chlorophenyl)carbamate                         chlorfenac                                                                              2,3,6-trichlorobenzeneacetic acid                                   chlorflureco-                                                                           methyl 2-chloro-9-hydroxy-9H-fluorene-9-                            methyl    carboxylate                                                         chloridazon                                                                             5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone                        chlorimuron                                                                             2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)ethyl-                                amino]carbonyl]amino]sulfonyl]benzoic acid,                                   ethyl ester                                                         chlornitrofen                                                                           1,3,5-trichloro-2-(4-nitrophenoxy)benzene                           chloropicrin                                                                            trichloronitromethane                                               chloroxuron                                                                             N'-[4-(4-chlorophenoxy)phenyl]-N,N-dimethyl-                                  urea                                                                chlorpropham                                                                            1-methylethyl 3-chlorophenylcarbamate                               chlorsulfuron                                                                           2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-                               2-yl)amino]carbonyl]benzenesulfonamide                              chlorthaldi-                                                                            dimethyl 2,3,5,6-tetrachloro-1,4-benzene-                           methyl    dicarboxylate                                                       chlorthiamid                                                                            2,6-dichlorobenzene carbothioamide                                  chlortoluron                                                                            N'-(3-chloro-4-methylphenyl)-N,N-dimethylurea                       cinmethylin                                                                             exo-1-methyl-4-(1-methylethyl)-2-[(2-methyl-                                  phenyl)methoxy]-7-oxabicyclo-[2.2.1]heptane                         clethodim (E,E)-(+)-2-[1-[[(3-chloro-2-propenyl)oxy]-                                   imino]propyl]-5-[2-(ethylthio)propyl]-3-hydroxy-                              2-cyclohexen-1-one                                                  clomazone 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-                                    isoxazolidinone                                                     cloproxydim                                                                             (E,E)-2-[1-[[(3-chloro-2-propenyl)oxy)imino]-                                 butyl]-5-[2-(ethylthio)propyl]-3-hydroxy-2-                                   cyclohexen-1-one                                                    clopyralid                                                                              3,6-dichloro-2-pyridinecarboxylic acid                              CMA       calcium salt of MAA                                                 cyanazine 2-[[4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl]-                              amino]-2-methylpropanenitrile                                       cycloate  S-ethyl cyclohexylethylcarbamothioate                               cycloxydim                                                                              2-[1-ethoxyimino)butyl]-3-hydroxy-5-(tetra-                                   hydro-2H-thiopyran-3-yl)-2-cyclohexene-1-one                        cycluron  3-cyclooctyl-1,1-dimethylurea                                       cyperquat 1-methyl-4-phenylpyridinium                                         cyprazine 2-chloro-4-(cyclopropylamino)-6-(isopropyl-                                   amino)- .sub.-s-triazine                                            cyprazole N-[5-(2-chloro-1,1-dimethylethyl)-1,3,4-                                      thiadiazol-2-yl]cyclopropanecarboxamide                             cypromid  3',4'-dichlorocyclopropanecarboxanilide                             dalapon   2,2-dichloropropanoic acid                                          dazomet   tetrahydro-3,5-dimethyl-2H-1,3,5-thiadiazine-2-                               thione                                                              DCPA      dimethyl 2,3,5,6-tetrachloro-1,4-benzene-                                     dicarboxylate                                                       desmedipham                                                                             ethyl [3-[[(phenylamino)carbonyl]oxy]phenyl]-                                 carbamate                                                           desmetryn 2-(isopropylamino)-4-(methylamino)-6-(methyl-                                 thio)- .sub.-s-triazine                                             diallate  S-(2,3-dichloro-2-propenyl)bis(1-methylethyl)-                                carbamothioate                                                      dicamba   3,6-dichloro-2-methoxybenzoic acid                                  dichlobenil                                                                             2,6-dichlorobenzonitrile                                            dichlorprop                                                                             (+)-2-(2,4-dichlorophenoxy)propanoic acid                           diclofopmethyl                                                                          (+)-2-[4-(2,4-dichlorophenoxy)phenoxy]-                                       propanoic acid, methyl ester                                        diethatyl N-(chloroacetyl)-N-(2,6-diethylphenyl)glycine                       difenoxuron                                                                             N' -[4-(4-methoxyphenoxy)phenyl]-N,N-dimethyl-                                urea                                                                difenzoquat                                                                             1,2-dimethyl-3,5-diphenyl-1H-pyrazolium ion                         diflufenican                                                                            N-(2,4-difluorophenyl)-2-(3-trifluoromethyl-                                  phenoxy)pyridine-3-carboxamide                                      dimefuron N'-[3-chloro-4-[5-(1,1-dimethylethyl)-2-oxo-1,3,4-                            oxadiazol-3(2H)-yl]phenyl]-N,N-dimethylurea                         dimethachlor                                                                            2-chloro-N-(2,6-dimethylphenyl)-N-(2-methoxy-                                 ethyl)acetamide                                                     dimethametryn                                                                           N-(1,2-dimethylpropyl)-N'-ethyl-6-(methylthio)-                               1,3,5-triazine-2,4-diamine                                          dimethipin                                                                              2,3-dihydro-5,6-dimethyl-1,4-dithiin 1,1,4,4-                                 tetraoxide                                                          dimethylarsinic                                                                         dimethylarsinic acid                                                dinitramine                                                                             N.sup.3,N.sup.3 -diethyl-2,4-dinitro-6-(trifluoromethyl)-                     1,3-benzenediamine                                                  dinoseb   2-(1-methylpropyl)-4,6-dinitrophenol                                dinoterb  2-(1,1-dimethylethyl)-4,6-dinitrophenol                             diphenamid                                                                              N,N-dimethyl-α-phenylbenzeneacetamide                         dipropetryn                                                                             6-(ethylthio)-N,N'-bis(1-methylethyl)-1,3,5-                                  triazine-2,4-diamine                                                diquat    6,7-dihydrodipyrido[1,2-a:2',1'-c]pyrazinediium                               ion                                                                 diuron    N'-(3,4-dichlorophenyl)-N,N-dimethylurea                            DNOC      2-methyl-4,6-dinitrophenol                                          DPX-V9360 2-[[(4,6-dimethoxypyrimidin-2-yl)amino-                                       carbonyl]aminosulfonyl]-N,N-dimethyl                                          3-pyridinecarboxamide                                               DSMA      disodium salt of MAA                                                dymron    N-(4-methylphenyl)-N'-(1-methyl-1-phenyl-                                     ethyl)urea                                                          eglinazine-ethyl                                                                        N-[4-chloro-6-(ethylamino)-1,3,5-triazin-2-                                   yl]glycine ethyl ester                                              endothall 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid                    EPTC      S-ethyl dipropylcarbamothioate                                      ethalfluralin                                                                           N-ethyl-N-(2-methyl-2-propenyl)-2,6-dinitro-4-                                (trifluoromethyl)benzenamine                                        ethidimuron                                                                             N-[5-(ethylsulfonyl)-1,3,4-thiadiazol-2-yl]-N,N'-                             dimethylurea                                                        ethofumesate                                                                            (+)-2-ethoxy-2,3-dihydro-3,3-dimethyl-5-benzo-                                furanyl methanesulfonate                                            fenac     2,3,6-trichlorobenzeneacetic acid                                   fenoprop  (+)-2-(2,4,5-trichlorophenoxy)propanoic acid                        fenoxaprop                                                                              (+)-2-[4-[(6-chloro-2-benzoxazolyl)oxy]  - phenoxy]-propanoic                 acid                                                                fenuron   N,N-dimethyl-N'-phenylurea                                          fenuron TCA                                                                             Salt of fenuron and TCA                                             flamprop-M                                                                              1-methylethyl N-benzoyl-N-(3-chloro-4-                              isopropyl fluorophenyl)-D-alanine                                             flamprop- methyl N-benzoyl-N-(3-chloro-4-fluorophenyl)-                       methyl    DL-alaninate                                                        fluazifop (+)-2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-                              phenoxy]propanoic acid                                              fluazifop-P                                                                             (R)-2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-                              phenoxy]propanoic acid                                              fluchloralin                                                                            N-(2-chloroethyl)-2,6-dinitro-N-propyl-4-                                     (trifluoromethyl)benzenamine                                        fluometuron                                                                             N,N-dimethyl-N'-[3-(trifluoromethyl)phenyl]-                                  urea                                                                fluralin  N-butyl-N-ethyl-2,6-dinitro-4-(trifluoromethyl)-                              benzenamine                                                         fluorodifen                                                                              -p-nitrophenyl α,α,α-trifluoro-2-nitro-                    -p-tolyl                                                                      ether                                                               fluoroglycofen                                                                          carboxymethyl 5-[2-chloro-4-(trifluoromethyl)-                                phenoxy]-2-nitrobenzoate                                            flurecol-butyl                                                                          butyl 9-hydroxy-9H-fluorene-9-carboxylate                           fluridone 1-methyl-3-phenyl-5-[3-(trifluoromethyl)-                                     phenyl]-4(1H)-pyridinone                                            flurochloridone                                                                         3-chloro-4-(chloromethyl)-1-[3-(trifluoromethyl)-                             phenyl]-2-pyrrolidinone                                             fluroxypyr                                                                              [(4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy]-                             acetic acid                                                         fomesafen 5-[2-chloro-4-(trifluoromethyl)phenoxy]-N-                                    (methylsulfonyl)-2-nitrobenzamide                                   fosamine- ethyl hydrogen (aminocarbonyl)-phosphonate                          ammonium  ammonium ethyl                                                      glufosinate-                                                                            ammonium 2-amino-4-(hydroxymethylphos-                              ammonium  phinyl)butanoate                                                    glyphosate                                                                              N-(phosphonomethyl)glycine                                          haloxyfop 2-[4-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-                             oxy]phenoxy]propanoic acid                                          hexaflurate                                                                             potassium hexafluoroarsenate                                        hexazinone                                                                              3-cyclohexyl-6-(dimethylamino)-1-methyl-1,3,5-                                triazine-2,4(1H,3H)-dione                                           imazametha-                                                                             6-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-                   benz       .sub.--m-toluic acid, methyl ester and 6-(4-isopropyl-                       4-methyl-5-oxo-2-imidazolin-2-yl)-p-toluic                                    acid, methyl ester                                                  imazapyr  (+)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-                              oxo-1H-imidazol-2-yl]-3-pyridinecarboxylic                                    acid                                                                imazaquin 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-                              1H-imidazol-2-yl]-3-quinolinecarboxylic acid                        imazethapyr                                                                             (+)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-                              oxo-1H-imidazol-2-yl]-5-ethyl-3-pyridine-                                     carboxylic acid                                                     ioxynil   4-hydroxy-3,5-diiodobenzonitrile                                    isocarbamid                                                                             N-(2-methylpropyl)-2-oxo-1-imidazolidine-                                     carboxamide                                                         isopropalin                                                                             4-(1-methylethyl)-2,6-dinitro-N,N-dipropyl-                                   benzenamine                                                         isoproturon                                                                             N-(4-isopropylphenyl)-N',N'-dimethylurea                            isouron   N'-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N,N-                                  dimethylurea                                                        isoxaben  N-[3-(1-ethyl-1-methylpropyl)-5-isoxazolyl]-2,6-                              dimethoxybenzamide                                                  karbutilate                                                                             3-[[(dimethylamino)carbonyl]amino]phenyl-(1,1-                                dimethylethyl)carbamate                                             lactofen  (+)-2-ethoxy-1-methyl-2-oxoethyl 5-[2-chloro-4-                               (trifluoromethyl)phenoxy]-2-nitrobenzoate                           lenacil   3-cyclohexyl-6,7-dihydro-1H-cyclopenta-                                       pyrimidine-2,4(3H,5H)-dione                                         linuron   N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl-                                   urea                                                                MAA       methylarsonic acid                                                  MAMA      monoammonium salt of MAA                                            MCPA      (4-chloro-2-methylphenoxy)acetic acid                               MCPA-     S-ethyl (4-chloro-2-methylphenoxy)ethane-                           thioethyl thioate                                                             MCPB      4-(4-chloro-2-methylphenoxy)butanoic acid                           mecoprop  (+)-2-(4-chloro-2-methylphenoxy)propanoic acid                      mefenacet 2-(2-benzothiazolyloxy)-N-methyl-N-phenyl                                     acetamide                                                           mefluidide                                                                              N-[2,4-dimethyl-5-[[(trifluoromethyl)sulfonyl]-                               amino]phenyl]acetamide                                              metamitron                                                                              4-amino-3-methyl-6-phenyl-1,2,4-triazin-5(4H)-                                one                                                                 metazachlor                                                                             2-chloro-N-(2,6-dimethylphenyl)-N-(1(H)-                                      pyrazol-1-ylmethyl)acetamide                                        methabenz-                                                                              1,3-dimethyl-3-(2-benzothiazolyl)urea                               thiazuron                                                                     methalpropalin                                                                          N-(2-methyl-2-propenyl)-2,6-dinitro-N-propyl-4-                               (trifluoromethyl)benzenamide                                        metham    methylcarbamodithioic acid                                          methazole 2-(3,4-dichlorophenyl)-4-methyl-1,2,4-                                        oxadiazolidine-3,5-dione                                            methoxuron                                                                              N'-(3-chloro-4-methoxyphenyl)-N,N-dimethyl-                                   urea                                                                methoxy-  (4-methoxy-3-methylphenyl)(3-methylphenyl)-                         phenone   methanone                                                           methyldymron                                                                            N-methyl-N'-(1-methyl-1-phenylethyl)-N-                                       phenylurea                                                          metobromuron                                                                            N'-(4-bromophenyl)-N-methoxy-N-methylurea                           metolachlo                                                                              2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-                                     methoxy-1-methylethyl)acetamide                                     metoxuron N'-(3-chloro-4-methoxyphenyl)-N,N-dimethyl-                                   urea                                                                metribuzin                                                                              4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-                                 1,2,4-triazin-5(4H)-one                                             metsulfuron                                                                             2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-                          methy     yl)amino]carbonyl]amino]sulfonyl]benzoic                                      acid, methyl ester                                                  MH        1,2-dihydro-3,6-pyridazinedione                                     molinate  S-ethyl hexahydro-1H-azepine-1-carbothioate                         monalide  N-(4-chlorophenyl)-2,2-dimethylpentanamide                          monolinuron                                                                             3-( -p-chlorophenyl)-1-methoxy-1-methylurea                         monuron   N'-(4-chlorophenyl)-N,N-dimethylurea                                MSMA      monosodium salt of MAA                                              naproanilide                                                                            2-(2-naphthalenyloxy)-N-phenylpropanamide                           napropamide                                                                             N,N-diethyl-2-(1-naphthalenyloxy)propanamide                        naptalam  2-[(1-naphthalenylamino)carbonyl]benzoic acid                       neburon   1-butyl-3-(3,4-dichlorophenyl)-1-methylurea                         nitralin  4-methylsulfonyl-2,6-dinitro-N,N-dipropyl-                                    antiline                                                            nitrofen  2,4-dichloro-1-(4-nitrophenoxy)benzene                              nitrofluorfen                                                                           2-chloro-1-(4-nitrophenoxy)-4-(trifluoromethyl)-                              benzene                                                             norea     N,N-dimethyl-N'-(octahydro-4,7-methano-1H-                                    inden-5-yl)urea 3aα,4α,5α,7α,7aα-i              somer                                                               norflurazon                                                                             4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)-                              phenyl]-3(2H)-pyridazinone                                          orbencarb S-[2-(chlorophenyl)methyl]diethylcarbamo-                                     thioate                                                             oryzalin  4-(dipropylamino)-3,5-dinitrobenzene-                                         sulfonamide                                                         oxadiazon 3-[2,4-dichloro-5-(1-methylethoxy)phenyl]-5-                                  (1,1-dimethylethyl)-1,3,4-oxadiazol-2(3H)-one                       oxyfluorfen                                                                             2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-                                       (trifluoromethyl)benzene                                            paraquat  1,1-'dimethyl-4,4'-dipyridinium ion                                 pebulate  S-propyl butylethylcarbamothioate                                   pendimethalin                                                                           N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitro-                                   benzenamine                                                         perfluidone                                                                             1,1,1-trifluoro-N-[2-methyl-4-(phenylsulfonyl)-                               phenyl]methanesulfonamide                                           phenisopham                                                                             3-[[(1-methylethoxy)carbonyl]amino]phenyl                                     ethylphenylcarbamate                                                phenmedipham                                                                            3-[(methoxycarbonyl)amino]phenyl-(3-methyl-                                   phenyl)carbamate                                                    picloram  4-amino-3,5,6-trichloro-2-pyridinecarboxylic acid                   piperophos                                                                              S-[2-(2-methyl-1-piperidinyl)-2-oxoethyl]-O,O-                                dipropyl phosphorodithioate                                         pretilachlor                                                                            2-chloro-N-(2,6-diethylphenyl)-N-(2-propoxy-                                  ethyl)acetamide                                                     procyazine                                                                              2-[[4-chloro-6-(cyclopropylamino)-1,3,5-triazine-                             2-yl]amino]-2-methylpropanenitrile                                  prodiamine                                                                              2,4-dinitro-N3,N3-dipropyl-6-(trifluoromethyl)-                               1,3-benzenediamine                                                  profluralin                                                                             N-(cyclopropylmethyl)-2,6-dinitro-N-propyl-4-                                 (trifluoromethyl)benzenamine                                        proglinazine-                                                                           N-[4-chloro-6-[(1-methylethyl)amino]-1,3,5-                         ethyl     triazin-2-yl]glycine ethyl ester                                    prometon  6-methoxy-N,N'-bis(1-methylethyl)-1,3,5-                                      triazine-2,4-diamine                                                prometryn N,N'-bis(1-methylethyl)-6-(methylthio)-1,3,5-                                 triazine-2,4-diamine                                                pronamide 3,5-dichloro-N-(1,1-dimethyl-2-propynyl)-                                     benzamide                                                           propachlor                                                                              2-chloro-N-(1-methylethyl)-N-phenylacetamide                        propanil  N-(3,4-dichlorophenyl)propanamide                                   propaquizafop                                                                           2-[[(1-methylethylidene)amino]oxy]ethyl 2-[4-                                 [(6-chloro-2-quinoxalinyl)oxy]phenoxy]-                                       propanoate                                                          propazine 6-chloro-N,N'-bis(1-methylethyl)-1,3,5-triazine-                              2,4-diamine                                                         propham   1-methylethyl phenylcarbamate                                       propyzamide                                                                             3,5-dichloro-N-(1,1-dimethyl-2-propynl)-                                      benzamide                                                           prosulfalin                                                                             N-[[4-(dipropylamino)-3,5-dinitrophenyl]-                                     sulfonyl]-S,S-dimethylsulfilimine                                   prosulfocarb                                                                            S-benzyldipropylthiocarbamate                                       prynachlor                                                                              2-chloro-N-(1-methyl-2-propynyl)acetanilide                         pyrazon   5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone                        pyrazosulfuron-                                                                         ethyl 5-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]-                    ethyl     carbonyl]amino]sulfonyl]-1-methyl-1H-                                         pyrazole-4-carboxylate                                              pyrazoxyfen                                                                             2-[[4-(2,4-dichlorobenzoyl)-1,3-dimethyl-1H-                                  pyrazol-5-yl]oxy]-1-phenylethanone                                  pyridate  O-(6-chloro-3-phenyl-4-pyridazinyl) S-octyl                                   carbonothioate                                                      quizalofop ethyl                                                                        (+)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]-                              propanoic acid, ethyl ester                                         secbumeton                                                                              N-ethyl-6-methoxy-N'-(1-methylpropyl)-1,3,5-                                  triazine-2,4-diamine                                                sethoxydim                                                                              2-[1-(ethoxyimino)butyl]-5-[2-(ethylthio)propyl]-                             3-hydroxy-2-cyclohexen-1-one                                        siduron   N-(2-methylcyclohexyl)-N'-phenylurea                                simazine  6-chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine                    simetryn  N,N'-diethyl-6-(methylthio)-1,3,5-triazine-2,4-                               diamine                                                             sodium chlorate                                                                         sodium chlorate                                                     sodium mono-                                                                            chloroacetic acid, sodium salt                                      chloroacetate                                                                 sulfometuron                                                                            2-[[[[(4,6-dimethyl-2-pyrimidinyl)amino]-                           methyl    carbonyl]amino]sulfonyl]benzoic acid, methyl                                  ester                                                               2,4,5-T   (2,4,5-trichlorophenoxy)acetic acid                                 2,3,6-TBA 2,3,6-trichlorobenzoic acid                                         TCA       trichloroacetic acid                                                tebutam   2,2-dimethyl-N-(1-methylethyl)-N-(phenyl-                                     methyl)propanamide                                                  tebuthiuron                                                                             N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]-                              N,N'-dimethylurea                                                   terbacil  5-chloro-3-(1,1-dimethylethyl)-6-methyl-2,4-                                  (1H,3H)-pyrimidinedione                                             terbuchlor                                                                              N-(butoxymethyl)-2-chloro-N-[2-(1,1-dimethyl-                                 ethyl)-6-methylphenyl]acetamide                                     terbumeton                                                                              N-(1,1-dimethylethyl)-N'-ethyl-6-methoxy-1,3,5-                               triazine-2,4-diamine                                                terbuthylazine                                                                          2-(tert-butylamino)-4-chloro-6-(ethylamino)- .sub.-s-                         triazine                                                            terbutol  2,6-di-tert-butyl- -p-tolyl methylcarbamate                         terbutryn N-(1,1-dimethylethyl)-N'-ethyl-6-(methylthio)-                                1,3,5-triazine-2,4-diamine                                          thifensulfuron                                                                          3-[[[[(4-methoxy-6-methyl-1,3,5,triazin-2-yl)-                                amino]carbonyl]amino]sulfonyl]2-thiophene-                                    carboxylic acid, methyl ester                                       thiameturon-                                                                            methyl 3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-                     methyl    2-yl)amino]carbonyl]amino]sulfonyl]2-                                         thiophenecarboxylate                                                thiazafluron                                                                            N,N'-dimethyl-N-[5-(trifluoromethyl)-1,3,4-                                   thiadiazol-2-yl]urea                                                thiobencarb                                                                             S-[(4-chlorophenyl)methyl] diethylcarbamo-                                    thioate                                                             tiocarbazil                                                                             S-(phenylmethyl) bis(1-methylpropyl)-                                         carbamothioate                                                      tralkoxydim                                                                             2-[1-(ethoxyimino)propyl]-3-hydroxy-5-(2,4,6-                                 trimethylphenyl)-2-cyclohexen-1-one                                 triallate S-(2,3,3-trichloro-2-propenyl) bis(1-methylethyl)-                            carbamothioate                                                      triasulfuron                                                                            2-(2-chloroethoxy)-N-[[(4-methoxy-6-methyl-                                   1,3,5-triazin-2-yl)amino]carbonyl]benzene-                                    sulfonamide                                                         tribenuron                                                                              2-[[[[N-(4-methoxy-6-methyl-1,3,5-triazine-2-yl)-                   methyl    N-methylamino]-carbonyl]amino]sulfonyl]-                                      benzoic acid, methyl ester                                          triclopyr [(3,5,6-trichloro-2-pyridinyl)oxy]acetic acid                       tridiphane                                                                              (+)2-(3,5-dichlorophenyl)-2-(2,2,2-                                           trichloroethyl)oxirane                                              trietazine                                                                              6-chloro-N,N,N'-triethyl-1,3,5-triazine-2,4-                                  diamine                                                             trifluralin                                                                             2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)-                                 benzenamine                                                         trimeturon                                                                              1- -p-chlorophenyl)-2,3,3-trimethylpseudourea                       2,4-D     (2,4-dichlorophenoxy)acetic acid                                    2,4-DB    4-(2,4-dichlorophenoxy)butanoic acid                                vernolate S-propyl dipropylcarbamothioate                                     xylachlor 2-chloro-N-(2,3-dimethylphenyl)-N-(1-methyl-                                  ethyl)acetamide                                                     ______________________________________                                    

Selective herbicidal properties of the subject compounds were discoveredin greenhouse tests as described below.

                                      TABLE 16                                    __________________________________________________________________________    General Structure I, m is 3, R.sup.1 is CH.sub.3 ; R.sup.6 is anti,           R.sup.5 and OQ are syn to the oxygen-containing bridge, Q is CH.sub.2 W                            Physical/Spectral data                                   Compound                                                                            R.sup.5                                                                           R.sup.6                                                                           W      (δ in CDCl.sub.3)                                  __________________________________________________________________________     1    OCH.sub.3                                                                         H   (2-CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 1.2-2.1(m, 11H),                                                    1.51(s, 3H), 2.31(s,3H), 3.25                                                 (m, 1H), 3.25(s, 3H), 3.45(m,                                                 1H), 4.28(d, 1H), 4.54(d, 1H),                                                7.17(m, 3H), 7.30(m, 1H).                                 3    H   OCH.sub.3                                                                         (2-CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 1.2-2.2(m, 11H),                                                    1.51(s, 3H), 2.30(s, 3H), 2.92                                                (m, 1H), 3.33(s, 3H), 3.50(m,                                                 1H), 4.28(m, 1H), 4.50(m,                                                     1H), 7.16(m, 3H), 7.29(m, 1H).                            5    H   OCH.sub.3                                                                         (2-CH.sub.3)C.sub.6 H.sub.4                                                          m.p. 62-68° C.                                                  (OQ is anti)                                                     6    OCH.sub.3                                                                         H   (2-CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 0.97(s, 3H), 1.4-2.1                                                (m, 11H), 1.50(s, 3H), 2.31(s,                                                3H), 3.10(s, 3H), 3.41(m,                                                     1H), 4.26(d, 1H), 4.54(d, 1H),                                                7.15(m, 3H), 7.29(m, 1H).                                __________________________________________________________________________    General Structure II, m is 3, R.sup.2 is CH.sub.3 ; R.sup.6 is anti,          R.sup.5 and OQ are syn to the oxygen-containing bridge, Q is CH.sub.2 W                            Physical/Spectral data                                   Compound                                                                            R.sup.5                                                                           R.sup.6                                                                           W      (δ in CDCl.sub.3)                                  __________________________________________________________________________     2    OCH.sub.3                                                                         H   (2-CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 1.1-2.2(m, 11H),                                                    1.50(s, 3H), 2.30(s, 3H), 3.2                                                 (m, 1H), 3.26(s, 3H), 3.48(m,                                                 1H), 4.33(d, 1H), 4.55(d, 1H),                                                7.16(m, 3H), 7.30(m, 1H).                                 4    H   OCH.sub.3                                                                         (2-CH.sub.3)C.sub.6 H.sub.4                                                          m.p. 102-103° C.                                   7    OCH.sub.3                                                                         CH.sub.3                                                                          (2-CH.sub.3)C.sub.6 H.sub.4                                                          m.p. 65-71° C.                                    __________________________________________________________________________    General Structure III, R.sup.1 is CH.sub.3 ;                                  OQ is syn to the oxygen-containing bridge, Q is CH.sub.2 W                                         Physical/Spectral data                                   Compound                                                                            n R.sup.2                                                                          R.sup.3                                                                          W      (δ in CDCl.sub.3)                                  __________________________________________________________________________     8    4 H  CH.sub.3                                                                         (2-CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 1.17(s, 3H),                                                        1.29(s, 3H), 1.5-2.1(m, 14H),                                                 2.34(s, 3H), 3.29(dd, 1H),                                                    4.44(d, 1H), 4.67(d, 1H),                                                     7.15(m, 3H), 7.36(m, 1H).                                 9    4 H  CH.sub.3                                                                         C.sub.6 H.sub.4                                                                      oil, NMR: 1.18(s, 3H),                                                        1.30(s, 3H), 1.4-2.1(m, 14H),                                                 3.30(dd, 1H), 4.48(d, 1H),                                                    4.69(d, 1H), 7.3(m, 5H).                                 10    4 H  CH.sub.3                                                                         2-FC.sub.6 H.sub.4                                                                   m.p. 67-69° C.                                    11    4 H  CH.sub.3                                                                         2-ClC.sub.6 H.sub.4                                                                  m.p. 41-43° C.                                    12    4 H  CH.sub.3                                                                         2-Cl-6-FC.sub.6 H.sub.3                                                              m.p. 74-75° C.                                    13    4 H  CH.sub.3                                                                         2,6-F.sub.2 C.sub.6 H.sub.3                                                          m.p. 100-101° C.                                  14    4 H  CH.sub.3                                                                         2,6-Cl.sub.2 C.sub.6 H.sub.3                                                         m.p. 58- 60° C.                                   15    4 H  Et 2-(CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 0.80(t, 3H),                                                        1.16(s, 3H), 1.3-2.1(m, 16H),                                                 2.33(s, 3H), 3.32(dd, 1H),                                                    4.43(d, 1H), 4.67(d, 1H),                                                     7.16(m, 3H), 7.36(m, 1H).                                16    4 H  Et 2-FC.sub.6 H.sub.5                                                                   oil, NMR: 0.80(t, 3H),                                                        1.17(s, 3H), 1.2-2.1(m, 16H),                                                 3.35(dd, 1H), 4.54(d, 1H),                                                    4.70(d, 1H), 6.9-7.3(m, 3H),                                                  7.49(dt, 1H).                                            17    2 CH.sub.3                                                                         CH.sub.3                                                                         (2-CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 0.78(s, 3H),                                                        1.12(s, 3H), 1.22(s, 3H),                                                     1.4(m, 2H), 1.6-2.0(m, 7H),                                                   2.34(s, 3H), 3.15(dd, 1H),                                                    4.46(d, 1H), 4.68(d, 1H),                                                     7.18(m, 3H), 7.39(m, 1H).                                18    2 CH.sub.3                                                                         CH.sub.3                                                                         C.sub.6 H.sub.5                                                                      oil, NMR: 0.77(s, 3H),                                                        1.11(s, 3H), 1.24(s, 3H),                                                     1.4(m, 2H), 1.6-2.0(m, 7H),                                                   3.14(dd, 1H), 4.47(d, 1H),                                                    4.74(d, 1H), 7.2-7.4(m, 5H).                             19    2 CH.sub.3                                                                         CH.sub.3                                                                         2-ClC.sub.6 H.sub.4                                                                  oil, NMR: 0.78(s, 3H),                                                        1.15(s, 3H), 1.23(s, 3H),                                                     1.4(m, 2H), 1.6-2.0(m, 7H),                                                   3.24(dd, 1H), 4.55(d, 1H),                                                    4.75(d, 1H), 7.25(m, 3H),                                                     7.61(m, 1H).                                             20    2 CH.sub.3                                                                         CH.sub.3                                                                         2-FC.sub.6 H.sub.4                                                                   oil, NMR: 0.78(s, 3H),                                                        1.11(s, 3H), 1.22(s, 3H),                                                     1.4(m, 2H), 1.6-2.0(m, 7H),                                                   3.18(dd, 1H), 4.55(d, 1H),                                                    4.73(d, 1H), 6.9-7.3(m, 3H),                                                  7.50(dt, 1H).                                            21    2 CH.sub.3                                                                         CH.sub.3                                                                         2,6-F.sub.2 C.sub.6 H.sub.3                                                          m.p. 76-78° C.                                    22    2 CH.sub.3                                                                         CH.sub.3                                                                         2-Cl-6-FC.sub.6 H.sub.3                                                              m.p. 82-85° C.                                    23    2 CH.sub.3                                                                         CH.sub.3                                                                         2,6-Cl.sub.2 C.sub.6 H.sub.3                                                         m.p. 97-100° C.                                   24    4 H  H  2-(CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 1.15(s, 3H),                                                        1.4-2.0(m, 14H), 2.36(s, 3H),                                                 3.38(dd, 1H), 4.24(m, 1H),                                                    4.46(d, 1H), 4.72(d, 1H),                                                     7.17(m, 3H), 7.34(m, 1H).                                25    4 H  H  2-FC.sub.6 H.sub.4                                                                   oil, NMR: 1.15(s, 3H),                                                        1.4-2.0(m, 14H), 3.42(dd, 1H),                                                4.23(m, 1H), 4.55(d, 1H),                                                     4.73(d, 1H), 6.9-7.3(m, 3H),                                                  7.48(dt, 1H).                                            26    2 CH.sub.3                                                                         H  2-(CH.sub.3)C.sub.6 H.sub.4                                                          oil, NMR: 0.79(s, 3H),                                                        1.10(s, 3H), 1.4(m, 2H),                                                      1.6-2.1(m, 7H), 2.36(s, 3H),                                                  3.18(dd, 1H), 3.87(m, 1H),                                                    4.46(d, 1H), 4.69(d, 1H),                                                     7.18(m, 3H), 7.35(m, 1H).                                27    2 CH.sub.3                                                                         H  C.sub.6 H.sub.5                                                                      oil, NMR: 0.78(s, 3H),                                                        1.12(s, 3H), 1.4(m, 2H),                                                      1.6-2.1(m, 7H), 3.20(dd, 1H),                                                 3.87(m, 1H), 4.48(d, 1H),                                                     4.73(d, 1H), 7.2-7.4(m, 5H).                             28    2 CH.sub.3                                                                         H  2-FC.sub.6 H.sub.4                                                                   oil, NMR: 0.79(s, 3H),                                                        1.10(s, 3H), 1.4(m, 2H),                                                      1.6-2.1(m, 7H), 3.23(dd, 1H),                                                 3.87(m, 1H), 4.56(d, 1H),                                                     4.74(d, 1H), 6.9-7.3(m, 3H),                                                  7.48(dt, 1H).                                            29    2 CH.sub.3                                                                         H  2-ClC.sub.6 H.sub.4                                                                  oil, NMR: 0.80(s, 3H),                                                        1.15(s, 3H), 1.4(m, 2H),                                                      1.6-2.2(m, 7H), 3.28(dd, 1H),                                                 3.88(m, 1H), 4.58(d, 1H),                                                     4.76(d, 1H), 7.25(m, 3H),                                                     7.58(m, 1H).                                             34    4 H  H  2-ClC.sub.6 H.sub.4                                                                  oil, NMR: 1.20(s, 3H),                                                        1.4-2.0(m, 14H), 3.48(dd, 1H),                                                4.25(m, 1H), 4.58(d, 1H),                                                     4.77(d, 1H), 7.1-7.4(m, 3H),                                                  7.56(m, 1H).                                             35    4 H  H  2-Cl-6-FC.sub.6 H.sub.3                                                              m.p. 68-70° C.                                    36    4 H  H  2,6-F.sub.2 C.sub.6 H.sub.3                                                          oil, NMR: 1.08(s, 3H),                                                        1.4-2.0(m, 14H), 3.39(dd, 1H),                                                4.20(m, 1H), 4.54(d, 1H),                                                     4.76(d, 1H), 6.87(m, 2H),                                                     7.25(m, 1H).                                             37    4 H  H  2,3-F.sub.2 C.sub.6 H.sub.3                                                          oil, NMR: 1.15(s, 3H),                                                        1.4-2.0(m, 14H), 3.43(dd, 1H),                                                4.23(m, 1H), 4.58(d, 1H),                                                     4.74(d, 1H), 7.06(m, 2H),                                                     7.27(m, 1H).                                             41    2 H  H  2-FC.sub.6 H.sub.4                                                                   oil, NMR: 1.10(s, 3H),                                                        1.3-2.3(m, 9H), 3.23(dd, 1H),                                                 4.19(m, 1H), 4.56(d, 1H),                                                     4.73(d, 1H), 6.9-7.3(m, 3H),                                                  7.48(dt, 1H).                                            43    2 CH.sub.3                                                                         H  2,6-F.sub.2 C.sub.6 H.sub.3                                                          oil, NMR: 0.79(s, 3H),                                                        1.03(s, 3H), 1.3-2.2(m, 9H),                                                  3.20(dd, 1H), 3.83(m, 1H),                                                    4.55(d, 1H), 4.75(d, 1H),                                                     6.8-6.9(m, 2H), 7.26(m, 1H).                             44    2 CH.sub.3                                                                         H  2-Cl, 6-FC.sub.6 H.sub.3                                                             oil, NMR: 0.79(s, 3H),                                                        1.05(s, 3H), 1.2-2.2(m, 9H),                                                  3.19(dd, 1H), 3.83(m, 1H),                                                    4.62(dd, 1H), 4.81(dd, 1H),                                                   6.96(m, 1H), 7.1-7.3(m, 2H).                             __________________________________________________________________________    General Structure V, m is 4, R.sup.1 ═R.sup.3 ═R.sup.4 is             CH.sub.3 ;                                                                    OQ is syn to the oxygen-containing bridge, Q is CH.sub.2 W.                   Compound                                                                              W      Physical/Spectral Data (δ in CDCl.sub.3)                 __________________________________________________________________________    30      2-(CH.sub.3)C.sub.6 H.sub.4                                                          m.p. 68-75° C.                                          31      C.sub.6 H.sub.5                                                                      m.p. 78-79° C.                                          32      2-FC.sub.6 H.sub.4                                                                   m.p. 82-84° C.                                          33      2-ClC.sub.6 H.sub.4                                                                  m.p. 79-80° C.                                          __________________________________________________________________________    General Structure XIII, R.sup.2 is Et; oxygen atoms are syn                                         Physical/Spectral Data                                  Compound                                                                            p W      Diastereomer                                                                         (δ in CDCl.sub.3)                                 __________________________________________________________________________    38    3 2-(CH.sub.3)C.sub.6 H.sub.4                                                          less polar                                                                           oil, NMR: 1.03(t, 3H),                                                        1.5-1.8(m, 7H), 1.8-2.0(m, 5H),                                               2.12(m, 2H), 2.31(s, 3H),                                                     4.12(m, 1H), 5.07(d, 1H),                                                     7.10(m, 2H), 7.18(t, 1H),                                                     7.42(d, 1H).                                            39    3 2-(CH.sub.3)C.sub.6 H.sub.4                                                          more polar                                                                           oil, NMR: 0.98(t, 3H),                                                        1.4-1.6(m, 5H), 1.7-1.9(m, 4H),                                               1.9-2.1(m, 2H), 2.1-2.2(m, 2H),                                               2.24(m, 1H), 2.31(s, 3H),                                                     3.89(m, 1H), 4.52(d, 1H),                                                     7.1-7.2(m, 3H), 7.51(d, 1H).                            40    3 C.sub.6 H.sub.5                                                                      more polar                                                                           oil, NMR: 0.98(t, 3H),                                                        1.4-2.3(m, 14H), 3.86(dd, 1H),                                                4.41(dd, 1H), 7.33(m, 5H).                              42    3 C.sub.6 H.sub.5                                                                      less polar                                                                           oil, NMR: 1.04(t, 3H),                                                        1.4-2.2(m, 14H), 4.11(dd, 1H),                                                4.88(d, 1H), 7.30(m, 5H).                               45    2 C.sub.6 H.sub.5                                                                      W is β                                                                          oil, NMR: 1.01(t, 3H),                                                        1.4-2.3(m, 12H), 3.87(dd, 1H),                                                4.31(m, 1H), 7.2-7.4(m, 5H).                            __________________________________________________________________________                          Physical/Spectral Data                                  Compound                                                                            P W      Diastereomer                                                                         (δ CDCl.sub.3)                                    __________________________________________________________________________    46    2 C.sub.6 H.sub.5                                                                      W is α                                                                         oil, NMR: 1.00(t, 3H),                                                        1.2-2.4(m, 12H), 3.83(dd, 1H),                                                5.05(m, 1H), 7.2-7.4(m, 5H).                            47    2 2-FC.sub.6 H.sub.4                                                                   W is β                                                                          oil, NMR. 1.02(t, 3H),                                                        1.4-1.7(m, 5H), 1.7-2.1(m, 6H),                                               2.24(dd, 1H), 3.88(d, 1H),                                                    4.67(d, 1H), 6.98(dd, 1H),                                                    7.13(t, 1H), 7.2(m, 1H),                                                      7.54(5, 1H).                                            __________________________________________________________________________

TEST A

Seeds of barley (Hordeum vulgare), barnyardgrass (Echinochloacrus-galli), bedstraw (Galium aparine), blackgrass (Alopecurusmyosuroides), cheatgrass (Bromus secalinus), chickweed (Stellariamedia), cocklebur (Xanthium pensylvanicum), corn (Zea mays), cotton(Gossypium hirsutum), crabgrass (Digitaria spp.), giant foxtail (Setariafaberii), lambsquarters (Chenopodium album), morningglory (Ipomoeahederacea), rape (Brassica napus), rice (Oryza sativa), sorghum (Sorghumbicolor), soybean (Glycine max), sugar beet (Beta vulgaris), velvetlead(Abutilon theophrasti), wheat (Triticum aestivum), wild buckwheat(Polygonum convolvulus), and wild oat (Avena fatua) and purple nutsedge(Cyperus rotundus) tubers were planted and treated preemergence withtest chemicals dissolved in a non-phytotoxic solvent. At the same time,these crop and weed species were also treated with postemergenceapplications of test compounds. Plants ranged in height from two toeighteen cm (one to four leaf stage) for postemergence treatments.Treated plants and controls were maintained in a greenhouse for twelveto sixteen days after which all species were compared to controls andvisually evaluated. Plant response ratings, summarized in Table A, arebased on a scale of 0 to 10 where 0 is no effect and 10 is completecontrol. A dash (-) response means no test result.

                                      TABLE A                                     __________________________________________________________________________               Rate (200 g/ha)                                                               COMPOUND                                                                      1 2 3 4 5 6  7 8 9 10                                                                              11                                                                              12 13                                                                              14                                                                              15                                                                              16                                                                              17                                                                              18 19                                                                              20                                                                              21                                                                              22                                                                              23                                                                              24                __________________________________________________________________________    POSTEMERGENCE                                                                 Barley     0 0 0 0 0 0  0 0 0 0 2 0  3 0 0 3 0 2        3                                                                             0                                                                             0                                                                             0 0 0                 Barnyardgrass                                                                            0 0 0 0 0 0  0 0 2 7 1 0  3 0 --                                                                              --                                                                              0 0        0                                                                             2                                                                             2                                                                             0 0 7                 Bedstraw   --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 0 0 0  0 0 0 0 0 0        3                                                                             0                                                                             3                                                                             0 0 2                 Blackgrass --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              2 2 0 2 0  2 2 0 3 7 --       6                                                                             4                                                                             7                                                                             7 2 3                 Cheatgrass 0 0 0 0 0 0  0 1 0 0 0 0  0 0 0 2 0 3        3                                                                             3                                                                             0                                                                             2 0 0                 Chickweed  --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              4 --                                                                              2 0 0  2 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Cocklebur  1 0 1 0 0 0  1 --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --       --                                                                            --                                                                            --                                                                            --                                                                              --                                                                              2                 Corn       0 0 0 0 0 0  0 0 0 0 0 0  0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Cotton     0 0 0 0 0 2  0 0 0 0 0 0  0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Crabgrass  0 0 0 0 0 0  0 0 0 0 0 0  0 0 0 0 2 3        0                                                                             0                                                                             0                                                                             0 0 2                 Giant foxtail                                                                            0 5 0 0 0 2  0 0 0 0 2 2  0 0 0 0 0 0        0                                                                             0                                                                             2                                                                             0 0 0                 Lambsquarters                                                                            --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              3 0 2 0 0  0 --                                                                              0 0 --                                                                              4        4                                                                             3                                                                             0                                                                             4 --                                                                              0                 Morningglory                                                                             0 0 0 0 1 0  0 0 0 0 0 0  0 0 1 0 0 0        0                                                                             0                                                                             1                                                                             0 0 0                 Nutsedge   0 0 0 0 0 0  0 0 0 0 0 0  0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Rape       --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 2 0 3  4 0 3 3 0 0        2                                                                             0                                                                             2                                                                             2 2 2                 Rice       0 0 0 0 0 0  0 0 0 0 0 0  2 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Sorghum    0 0 0 0 0 0  0 0 0 0 0 0  0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Soybean    0 0 0 0 0 0  0 0 0 0 0 0  1 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Sugar beet 0 0 0 0 0 0  0 1 1 3 5 2  6 3 7 5 0 2        2                                                                             0                                                                             3                                                                             2 2 4                 Velvetleaf 4 0 0 0 0 0  0 0 0 0 0 1  2 0 0 0 --                                                                              --       --                                                                            0                                                                             --                                                                            0 0 5                 Wheat      0 0 0 0 0 0  0 0 0 0 2 0  2 3 0 2 0 0        0                                                                             0                                                                             2                                                                             0 0 2                 Wild buckwheat                                                                           --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              2 3 0 2 0  2 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 2                 Wild oat   0 0 0 0 0 0  0 0 0 0 0 0  0 2 0 0 0 3        2                                                                             0                                                                             3                                                                             0 0 2                 __________________________________________________________________________                       Rate (200 g/ha)                                                               COMPOUND                                                                      25                                                                              26                                                                              27                                                                              28                                                                              29                                                                              30                                                                              31                                                                              32                                                                              33                                                                              34                                                                              35                                                                              36                                                                              37                                                                              38                                                                              39                                                                              40                                                                              41                                                                              43                                                                              44                                                                              45                                                                              46                                                                              47               __________________________________________________________________________            POSTEMERGENCE                                                                 Barley     0 0 0 2 2 0 0 0 0 0 0 0 2 0 0 0 3 0       0                                                                             0                                                                             0                                                                             0                        Barnyardgrass                                                                            9 9 9 9 9 0 0 0 0 9 8 9 9 0 0 8 9 9       6                                                                             0                                                                             0                                                                             0                        Bedstraw   2 2 0 0 2 0 0 0 0 0 0 0 0 0 0 0 2 0       0                                                                             0                                                                             0                                                                             2                        Blackgrass 3 2 4 0 0 0 0 0 0 3 0 9 5 0 0 8 9 2       3                                                                             0                                                                             0                                                                             0                        Cheatgrass 0 3 2 0 0 0 0 0 0 0 0 0 0 0 2 2 3 0       0                                                                             0                                                                             0                                                                             0                        Chickweed  0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 2 3 0       0                                                                             0                                                                             0                                                                             0                        Cocklebur  2 1 --                                                                              2 1 2 2 2 2 --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0       0                                                                             3                                                                             0                                                                             0                        Corn       0 1 1 2 1 0 0 0 0 0 0 0 0 0 0 0 9 1       0                                                                             0                                                                             0                                                                             0                        Cotton     0 0 0 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0                        Crabgrass  8 0 0 0 0 0 0 0 0 0 0 3 --                                                                              0 0 3 9 0       0                                                                             0                                                                             0                                                                             0                        Giant foxtail                                                                            1 0 2 3 0 2 0 0 0 0 0 0 0 0 0 0 5 0       0                                                                             0                                                                             0                                                                             0                        Lambsquarters                                                                            0 0 0 0 0 0 2 0 0 3 0 0 0 0 0 5 --                                                                              5       9                                                                             0                                                                             0                                                                             2                        Morningglory                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0                        Nutsedge   0 0 0 --                                                                              0 0 0 0 --                                                                              0 --                                                                              0 --                                                                              --                                                                              0 --                                                                              0 --      --                                                                            0                                                                             0                                                                             0                        Rape       2 2 2 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0                        Rice       0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0       0                                                                             0                                                                             0                                                                             0                        Sorghum    0 1 1 4 1 0 0 0 0 0 0 0 0 0 0 0 2 0       0                                                                             0                                                                             0                                                                             0                        Soybean    0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 3 0       0                                                                             0                                                                             0                                                                             0                        Sugar beet 4 5 3 4 3 0 0 0 0 2 0 0 0 0 2 3 0 0       0                                                                             0                                                                             0                                                                             0                        Velvetleaf 5 4 1 5 2 0 0 0 0 0 3 3 0 0 0 0 7 --      3                                                                             0                                                                             0                                                                             0                        Wheat      0 0 2 2 0 0 0 0 0 0 0 0 0 0 0 2 2 0       0                                                                             0                                                                             0                                                                             0                        Wild buckwheat                                                                           2 0 0 0 0 2 2 0 0 3 9 --                                                                              3 0 3 4 2 0       0                                                                             0                                                                             0                                                                             0                        Wild oat   2 0 2 2 0 0 0 0 0 0 0 0 2 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0                __________________________________________________________________________               Rate (50 g/ha)                                                                COMPOUND                                                                      1 2 3 4 5 6  7 8 9 10                                                                              11                                                                              12                                                                              13                                                                              14                                                                              15                                                                              16                                                                              17                                                                              18 19                                                                              20                                                                              21                                                                              22                                                                              23                                                                              24                                                                              25               __________________________________________________________________________    POSTEMERGENCE                                                                 Barley     0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        2                                                                             0                                                                             0                                                                             0 0 0 0                Barnyardgrass                                                                            0 0 0 0 0 0  0 0 0 0 0 0 1 0 --                                                                              --                                                                              0 0        0                                                                             0                                                                             0                                                                             0 0 0 2                Bedstraw   --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Blackgrass --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 0 0 0 2 0 0 0 6 8        --                                                                            --                                                                            2                                                                             7 2 2 2                Cheatgrass 0 0 0 0 0 0  0 0 0 0 0 0 0 --                                                                              0 0 0 3        3                                                                             0                                                                             0                                                                             0 0 0 0                Chickweed  --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              --                                                                              0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Cocklebur  1 0 1 0 0 0  0 --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --       --                                                                            --                                                                            --                                                                            --                                                                              --                                                                              --                                                                              --               Corn       0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Cotton     0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Crabgrass  0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Giant foxtail                                                                            0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Lambsquarters                                                                            --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 --                                                                              0 0 0 0 0 0 0 --       0                                                                             2                                                                             0                                                                             0 0 0 0                Morningglory                                                                             0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Nutsedge   --                                                                              0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Rape       --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 3 0 0 0 0 3 2 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Rice       0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Sorghum    0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Soybean    0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Sugar beet 0 0 0 0 0 0  0 0 0 3 4 4 5 3 4 4 0 0        0                                                                             0                                                                             4                                                                             1 0 2 3                Velvetleaf 0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             --                                                                            --                                                                            --                                                                              --                                                                              2 0                Wheat      0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Wild buckwheat                                                                           --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 2 0 0 0 0 0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0 0                Wild oat   0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0        2                                                                             0                                                                             2                                                                             0 0 0 0                __________________________________________________________________________               Rate (50 g/ha)                              Rate (10 g/ha)                    COMPOUND                                    COMPOUND                          26                                                                              27                                                                              28                                                                              29                                                                              30                                                                              31                                                                              32                                                                              33                                                                              34                                                                              35                                                                              36                                                                              37                                                                              38                                                                              39                                                                              40                                                                              41                                                                              42                                                                              43                                                                              44                                                                              45                                                                              46                                                                              47                                                                              42                     __________________________________________________________________________    POSTEMERGENCE                                                                 Barley     0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Barnyardgrass                                                                            4 3 5 1 0 0 0 0 2 2 5 4 0 0 2 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Bedstraw   0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Blackgrass 0 2 2 0 0 0 0 0 0 0 7 0 0 0 4 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Cheatgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Chickweed  0 0 0 0 0 0 0 0 0 0 --                                                                              0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Cocklebur  0 1 --                                                                              0 0 0 --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0 --      0                                                                             0                                                                             0                                                                             0 0                      Corn       0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Cotton     0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Crabgrass  0 0 0 0 0 0 0 0 0 0 0 --                                                                              0 0 0 3 0 0       0                                                                             0                                                                             0                                                                             0 0                      Giant foxtail                                                                            0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Lambsquarters                                                                            0 0 0 0 0 0 0 0 0 0 0 0 --                                                                              --                                                                              2 2 0 0       0                                                                             0                                                                             0                                                                             0 0                      Morningglory                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Nutsedge   0 0 0 0 0 0 0 0 0 0 0 0 0 0 --                                                                              --                                                                              0 0       0                                                                             0                                                                             0                                                                             0 0                      Rape       0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Rice       0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Sorghum    0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0       0                                                                             0                                                                             0                                                                             0 0                      Soybean    0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Sugar beet 4 3 3 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Velvetleaf 1 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Wheat      0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Wild buckwheat                                                                           0 0 0 0 0 0 0 0 0 0 3 0 0 2 2 0 0 --      --                                                                            0                                                                             0                                                                             0 0                      Wild oat   0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      __________________________________________________________________________               Rate (200 g/ha)                                                               COMPOUND                                                                      1 2 3 4 5 6 7 8 9 10 11                                                                              12                                                                              13 14                                                                              15                                                                              16                                                                              17                                                                              18 19                                                                              20                                                                              21                                                                              22                                                                              23                                                                              24                __________________________________________________________________________    PREEMERGENCE                                                                  Barley     0 0 0 0 0 0 0 0 0 0  0 0 0  0 2 0 0 0        0                                                                             0                                                                             0                                                                             0 0 2                 Barnyardgrass                                                                            9 1 8 0 0 9 0 7 8 10 2 9 10 0 0 0 0 7        2                                                                             4                                                                             8                                                                             1 0 10                Bedstraw   --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0 --                                                                              0  0 0 0  0 3 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Blackgrass --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              2 0 3  0 2 4  0 3 2 0 2        0                                                                             2                                                                             0                                                                             0 0 4                 Cheatgrass 0 0 0 0 0 0 0 0 2 2  0 0 6  0 4 2 0 0        0                                                                             0                                                                             0                                                                             0 0 5                 Chickweed  --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0 0 0  0 0 4  0 0 6 0 4        0                                                                             0                                                                             0                                                                             0 0 2                 Cocklebur  --                                                                              0 0 0 --                                                                              --                                                                              0 --                                                                              --                                                                              -- --                                                                              --                                                                              -- --                                                                              --                                                                              --                                                                              --                                                                              --       --                                                                            --                                                                            --                                                                            --                                                                              --                                                                              --                Corn       0 0 0 0 0 0 0 0 0 0  0 0 1  0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 1                 Cotton     0 0 0 0 0 0 0 0 0 0  0 0 0  0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Crabgrass  8 4 9 0 0 3 0 2 7 8  0 3 9  0 0 0 0 0        0                                                                             2                                                                             0                                                                             0 0 9                 Giant foxtail                                                                            9 6 9 0 0 8 0 3 5 6  3 6 8  0 0 0 0 3        5                                                                             2                                                                             0                                                                             2 0 8                 Lambsquarters                                                                            --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0 --                                                                              3  0 0 0  0 0 0 0 3        0                                                                             6                                                                             0                                                                             0 0 0                 Morningglory                                                                             0 0 0 0 0 0 0 0 0 0  0 0 0  0 0 0 0 --       --                                                                            0                                                                             0                                                                             0 0 0                 Nutsedge   0 0 --                                                                              0 0 9 0 0 0 3  0 0 0  0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 4                 Rape       --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0 0 0  2 0 0  0 2 2 0 0        0                                                                             0                                                                             0                                                                             0 0 3                 Rice       0 0 0 0 0 0 0 0 0 0  0 2 0  0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 3                 Sorghum    0 0 0 0 0 0 0 0 0 0  0 0 0  0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 2                 Soybean    0 0 0 0 0 0 0 0 0 0  0 0 2  0 0 0 0 0        0                                                                             0                                                                             0                                                                             0 0 1                 Sugar beet 0 0 0 0 0 0 0 0 4 1  2 2 2  2 4 3 0 0        0                                                                             0                                                                             0                                                                             0 0 3                 Velvetleaf 1 0 0 0 0 0 0 0 0 0  0 0 1  0 0 0 0 0        0                                                                             0                                                                             0                                                                             2 0 0                 Wheat      0 0 0 0 0 0 0 0 0 0  0 0 0  0 2 0 0 0        0                                                                             0                                                                             0                                                                             0 0 2                 Wild buckwheat                                                                           --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0 6 2  0 0 0  2 3 0 0 0        0                                                                             0                                                                             0                                                                             0 0 0                 Wild oat   0 0 0 0 0 0 0 0 0 0  0 0 2  0 0 0 0 0        0                                                                             0                                                                             3                                                                             0 0 2                 __________________________________________________________________________                       Rate (200 g/ha)                                                               COMPOUND                                                                      25                                                                              26                                                                              27                                                                              28                                                                              29                                                                              30                                                                              31                                                                              32                                                                              33                                                                              34                                                                              35                                                                              36                                                                              37                                                                              38                                                                              39                                                                              40                                                                              41                                                                              43                                                                              44                                                                              45                                                                              46                                                                              47               __________________________________________________________________________            PREEMERGENCE                                                                  Barley     2 2 2 2 0 0 0 0 0 0 0 0 0 0 0 0 3 0       0                                                                             0                                                                             0                                                                             0                        Barnyardgrass                                                                            10                                                                              10                                                                              10                                                                              10                                                                              10                                                                              0 7 2 0 10                                                                              9 10                                                                              10                                                                              0 4 10                                                                              10                                                                              10      10                                                                            7                                                                             0                                                                             1                        Bedstraw   0 0 0 0 0 0 0 2 0 0 0 2 0 0 0 0 7 --      --                                                                            0                                                                             0                                                                             0                        Blackgrass 9 6 6 2 6 4 6 7 3 3 5 9 3 0 2 9 --                                                                              7       6                                                                             7                                                                             0                                                                             4                        Cheatgrass 2 4 3 4 3 1 3 2 --                                                                              0 0 4 2 0 0 3 4 5       0                                                                             7                                                                             0                                                                             3                        Chickweed  0 2 3 0 4 0 0 0 --                                                                              0 0 0 2 0 0 0 2 5       2                                                                             0                                                                             0                                                                             0                        Cocklebur  1 0 0 1 0 --                                                                              --                                                                              --                                                                              0 --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0       0                                                                             0                                                                             0                                                                             0                        Corn       2 1 3 5 3 0 0 0 0 0 0 2 0 0 0 3 10                                                                              1       0                                                                             0                                                                             3                                                                             6                        Cotton     0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0       0                                                                             0                                                                             0                                                                             0                        Crabgrass  9 9 10                                                                              10                                                                              9 2 2 0 0 9 9 9 9 0 7 10                                                                              10                                                                              10      8                                                                             9                                                                             0                                                                             --                       Giant foxtail                                                                            9 10                                                                              10                                                                              10                                                                              10                                                                              8 9 8 5 8 8 9 9 0 8 9 10                                                                              7       7                                                                             5                                                                             1                                                                             8                        Lambsquarters                                                                            0 0 3 0 0 0 0 0 3 0 2 3 0 0 5 0 5 2       2                                                                             0                                                                             0                                                                             0                        Morningglory                                                                             0 0 --                                                                              0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0                        Nutsedge   0 --                                                                              0 --                                                                              0 0 --                                                                              --                                                                              0 0 0 0 0 0 0 0 2 0       0                                                                             0                                                                             0                                                                             0                        Rape       2 2 2 2 0 0 0 0 0 0 0 0 0 0 0 0 3 0       0                                                                             0                                                                             0                                                                             0                        Rice       0 0 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0                        Sorghum    2 2 1 1 0 0 0 0 0 0 0 3 2 0 0 5 3 1       0                                                                             0                                                                             0                                                                             0                        Soybean    0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 4 0       0                                                                             0                                                                             0                                                                             1                        Sugar beet 3 2 4 3 2 0 0 0 0 0 0 0 0 0 0 0 4 0       0                                                                             0                                                                             0                                                                             0                        Velvetleaf 2 2 1 4 2 0 0 0 0 0 5 6 3 0 0 2 8 5       2                                                                             0                                                                             0                                                                             0                        Wheat      0 0 3 2 2 0 0 0 0 0 0 0 0 0 0 2 2 2       0                                                                             0                                                                             0                                                                             0                        Wild buckwheat                                                                           0 0 0 0 0 0 0 0 0 0 --                                                                              --                                                                              --                                                                              0 0 2 2 --      --                                                                            0                                                                             0                                                                             0                        Wild oat   2 2 4 5 4 0 2 2 0 0 0 8 0 0 0 4 7 8       2                                                                             0                                                                             0                                                                             0                __________________________________________________________________________    Rate (50 g/ha)                                                                COMPOUND                                                                                 1 2 3 4 5 6  7 8 9 10                                                                              11                                                                              12                                                                              13                                                                              14                                                                              15                                                                              16                                                                              17                                                                              18                                                                              19                                                                              20                                                                              21                                                                              22                                                                              23                                                                              24                                                                              25                __________________________________________________________________________    PREEMERGENCE                                                                  Barley     0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Barnyardgrass                                                                            0 0 0 0 0 0  0 1 2 3 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 8 10                Bedstraw   --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Blackgrass --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 2                 Cheatgrass 0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 2 0                 Chickweed  --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Cocklebur  --                                                                              0 0 0 0 0  0 --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --      --                                                                            --                                                                            --                                                                            --                                                                              --                                                                              0 0                 Corn       0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Cotton     0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Crabgrass  6 0 0 0 0 2  0 0 2 2 0 0 0 0 0 0 0 0       0                                                                             2                                                                             0                                                                             0 0 5 8                 Giant foxtail                                                                            0 0 5 0 0 4  0 0 0 2 0 0 0 0 0 0 0 0       3                                                                             2                                                                             0                                                                             0 0 6 7                 Lambsquarters                                                                            --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 2 2 0 0 0 0 0 0 0 3       0                                                                             3                                                                             0                                                                             0 0 0 0                 Morningglory                                                                             0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Nutsedge   0 0 --                                                                              0 0 0  0 0 0 0 0 0 0 0 0 0 --                                                                              0       --                                                                            0                                                                             0                                                                             0 0 --                                                                              0                 Rape       --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 2 0                 Rice       0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Sorghum    0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Soybean    0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Sugar beet 0 0 0 0 0 0  0 0 0 0 0 0 0 0 2 2 0 0       0                                                                             0                                                                             0                                                                             0 0 2 2                 Velvetleaf 0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Wheat      0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Wild buckwheat                                                                           --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              -- --                                                                              0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                 Wild oat   0 0 0 0 0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             2                                                                             0 0 0 0                 __________________________________________________________________________               Rate (50 g/ha)                              Rate (10 g/ha)                    COMPOUND                                    COMPOUND                          26                                                                              27                                                                              28                                                                              29                                                                              30                                                                              31                                                                              32                                                                              33                                                                              34                                                                              35                                                                              36                                                                              37                                                                              38                                                                              39                                                                              40                                                                              41                                                                              42                                                                              43                                                                               44                                                                             45                                                                              46                                                                              47                                                                              42                     __________________________________________________________________________    PREEMERGENCE                                                                  Barley     0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Barnyardgrass                                                                            10                                                                              10                                                                              10                                                                              10                                                                              0 0 0 0 6 8 10                                                                              6 0 0 5 10                                                                              0 10      8                                                                             1                                                                             0                                                                             2 0                      Bedstraw   0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Blackgrass 0 0 0 2 4 4 2 3 0 5 7 2 0 0 4 5 0 2       2                                                                             0                                                                             0                                                                             0 0                      Cheatgrass 0 0 0 --                                                                              0 0 0 3 0 0 0 0 0 0 2 0 0 0       0                                                                             2                                                                             0                                                                             0 0                      Chickweed  0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 --                                                                              --      0                                                                             0                                                                             0                                                                             0 0                      Cocklebur  --                                                                              0 --                                                                              0 --                                                                              --                                                                              0 --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              0 0       0                                                                             0                                                                             0                                                                             0 0                      Corn       0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0       0                                                                             0                                                                             0                                                                             0 0                      Cotton     0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Crabgrass  2 5 8 5 0 0 0 0 2 0 9 5 0 2 9 9 0 9       7                                                                             8                                                                             0                                                                             3 0                      Giant foxtail                                                                            8 9 10                                                                              9 0 3 2 0 4 6 8 5 0 0 7 8 0 3       3                                                                             1                                                                             0                                                                             0 0                      Lambsquarters                                                                            0 0 0 0 0 0 0 0 0 0 3 0 0 3 --                                                                              3 0 0       0                                                                             0                                                                             0                                                                             0 0                      Morningglory                                                                             0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Nutsedge   0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       --                                                                            0                                                                             0                                                                             0 0                      Rape       0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0       0                                                                             0                                                                             0                                                                             0 0                      Rice       0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Sorghum    0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0       0                                                                             0                                                                             0                                                                             0 0                      Soybean    0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Sugar beet 0 2 2 2 0 0 0 0 0 0 0 0 0 0 0 2 0 0       0                                                                             0                                                                             0                                                                             0 0                      Velvetleaf 1 0 2 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Wheat      0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0                      Wild buckwheat                                                                           0 0 0 0 0 0 0 0 --                                                                              --                                                                              --                                                                              --                                                                              0 0 0 0 --                                                                              --      --                                                                            0                                                                             0                                                                             0 --                     Wild oat   0 2 3 2 0 0 0 0 0 0 0 0 0 0 2 0 0 3       0                                                                             0                                                                             0                                                                             0 0                      __________________________________________________________________________

TEST B

The compounds evaluated in this test were formulated in a non-phytoxicsolvent and applied to the soil surface before plant seedlings emerged(preemergence application), to water that covered the soil surface(paddy application), and to plants that were in the one-to-four leafstage (postemergence application). A sandy loam soil was used for thepreemergence and postemergence tests, while a silt loam soil was used inthe paddy test. Water depth was approximately 2.5 cm for the paddy testand was maintained at this level for the duration of the test.

Plant species in the preemergence and postemergence tests consisted ofbarley (Hordeum vulgare), bedstraw (Galium aparine), blackgrass(Alopecurus myosuroides), chickweed (Stellaria media), corn (Zea mays),cotton (Gossypium hirsutum), crabgrass (Digitaria sanguinalis), downybrome (Bromus tectorum), giant foxtail (Setaria faberii), lambsquarters(Chenopodium album), morningglory (Ipomoea hederacea), pigweed(Amaranthusretroflexus), rape (Brassica napus), ryegrass (Loliummultiflorum), sorghum (Sorghum bicolor), soybean (Glycine max),speedwell (Veronica persica), sugar beet (Beta vulgaris), velvetlead(Abutilon theophrasti), wheat (Triticum aestivum), wild buckwheat(Polygonum convolvulus), and wild oat (Avena fatua). All plant specieswere planted one day before application of the compound for thepreemergence portion of this test. Plantings of these species wereadjusted to produce plants of appropriate size for the postemergenceportion of the test. Plant species in the paddy test consisted ofbarnyardgrass (Echinochloa crus-galli), rice (Oryza sativa), umbrellasedge (Cyperus difformis) and duck salad (Heteranthera limosa).

All plant species were grown using normal greenhouse practices. Visualevaluations of injury expressed on treated plants, when compared tountreated controls, were recorded approximately fourteen to twenty onedays after application of the test compound. Plant response ratings,summarized in Table B, were recorded on a 0 to 10 scale where 0 is noeffect and 10 is complete control. A dash (-) response means no testresult.

                                      TABLE B                                     __________________________________________________________________________             Rate                                                                          (500 g/ha)                                                                           (250 g/ha)             (125 g/ha)        (62 g/ha)                     COMPOUND                                                                      40 41  25 26                                                                              27                                                                              28                                                                              29 36 40 41 43                                                                              25 26                                                                              27                                                                              28                                                                              29                                                                              36 40                                                                              41                                                                              25  26               __________________________________________________________________________    POSTEMERGENCE                                                                 Barley Igri                                                                            4  1   1  2 0 2 0  0  4  0  --                                                                              0  0 0 0 0 0  2 0 0   0                Bedstraw 0  8   2  0 0 2 2  5  0  6  --                                                                              2  0 0 0 0 0  0        3                                                                    1        0               Blackgrass                                                                             10 9   9  5 7 5 4  9  9  9  --                                                                              8  2 7 4 1 9  4        9                                                                    4        0               Chickweed                                                                              0  5   2  4 6 4 0  4  0  4  --                                                                              0  2 3 0 0 2  0        4                                                                    0        0               Corn     0  --  0  0 0 0 0  3  0  2  --                                                                              0  0 0 0 0 0  0        0                                                                    0        0               Cotton   0  --  0  0 0 0 0  4  0  0  --                                                                              0  0 0 0 0 0  0        0                                                                    0        0               Crabgrass                                                                              4  9   4  4 4 5 0  6  0  8  --                                                                              3  2 0 3 0 4  0        5                                                                    2        0               Downy brome                                                                            3  3   2  1 3 0 4  0  0  0  --                                                                              0  0 2 0 1 0  0        0                                                                    0        0               Duck salad                                                                             7  6   0  0 9 9 0  0  3  5  6 0  0 1 6 0 0  3        2                                                                    0        0               Giant foxtail                                                                          8  9   5  6 7 7 4  9  7  5  --                                                                              3  4 6 6 3 6  3        3                                                                    0        0               Lambsquarters                                                                          5  9   4  3 3 2 3  6  4  9  --                                                                              1  0 2 2 0 6  0        8                                                                    0        0               Morningglory                                                                           0  --  5  0 0 0 4  0  0  2  --                                                                              3  0 0 0 0 0  0        0                                                                    0        0               Pigweed  0  4   4  0 0 0 0  5  0  2  --                                                                              3  0 0 0 0 2  0        0                                                                    0        0               Rape     0  0   0  0 0 0 0  0  0  0  --                                                                              0  0 0 0 0 0  0        0                                                                    0        0               Ryegrass 9  9   7  2 3 4 2  2  7  7  --                                                                              4  2 1 2 0 0  4        6                                                                    2        0               Sorghum  7  4   0  0 0 0 0  3  3  3  --                                                                              0  0 0 0 0 2  2        2                                                                    0        0               Soybean  0  --  0  0 0 3 0  0  0  2  --                                                                              0  0 0 2 0 0  0        0                                                                    0        0               Speedwell                                                                              0  5   6  5 0 2 0  8  0  5  --                                                                              2  2 0 0 0 5  0        3                                                                    0        0               Sugar beet                                                                             7  8   3  0 0 0 0  2  0  0  --                                                                              2  0 0 0 0 0  0        0                                                                    0        0               Velvetleaf                                                                             0  6   4  6 0 0 4  6  0  4  --                                                                              3  3 0 0 0 4  0        2                                                                    0        2               Wheat    4  3   0  1 0 1 3  0  4  3  --                                                                              0  0 0 0 0 0  2        3                                                                    0        0               Wild buckwheat                                                                         -- 9   3  0 0 0 3  7  -- 8  --                                                                              2  0 0 0 0 7  --       7                                                                    0                        Wild oat 3  2   2  2 1 0 0  0  0  2  --                                                                              0  0 0 0 0 0  0        0                                                                    0        0               Barnyardgrass                                                                          10 10  9  9 9 9 10 10 10 10 9 9  9 9 9 9 10 9        10                                                                   9        9               Rice Japonica                                                                          8  9   0  6 6 2 0  2  8  8  9 0  0 2 0 0 1  7        7                                                                    0        0               Umbrella sedge                                                                         9  9   8  9 9 9 9  6  9  9  9 7  9 9 9 9 2  9        8                                                                    5        9               __________________________________________________________________________             Rate                                                                          (62 g/ha)        (31 g/ha)        (16 g/ha)      (4 g/ha)                     COMPOUND                                                                      27 28                                                                              29                                                                              36 40                                                                              41 43                                                                              25 26                                                                              27                                                                              28                                                                              29                                                                              36                                                                              40                                                                              41                                                                              25 26                                                                              27                                                                              28                                                                              29                                                                              36                                                                              43                                                                              43                  __________________________________________________________________________    POSTEMERGENCE                                                                 Barley Igri                                                                            0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0 0 0 0 --                                                                              --                  Bedstraw 0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Blackgrass                                                                             2  1 0 3  0 9  --                                                                              2  0 2 0 0 0 0 4 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Chickweed                                                                              0  0 0 0  0 2  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Corn     0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Cotton   0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Crabgrass                                                                              0  3 0 2  0 4  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Downy brome                                                                            0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Duck salad                                                                             0  2 0 0  0 0  0 0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             0 0                   Giant foxtail                                                                          0  3 0 2  0 3  --                                                                              0  0 0 3 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Lambsquarters                                                                          0  0 0 2  0 8  --                                                                              0  0 0 0 0 2 0 8 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Morningglory                                                                           0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Pigweed  0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Rape     0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Ryegrass 0  0 0 0  2 4  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Sorghum  0  0 0 2  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Soybean  0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Speedwell                                                                              0  0 0 5  0 3  --                                                                              0  0 0 0 0 3 0 0 0  0 0       0                                                                             0                                                                             3                                                                             --                                                                              --                  Sugar beet                                                                             0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Velvetleaf                                                                             0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Wheat    0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Wild buckwheat                                                                         0  0 0 3  0 7  --                                                                              0  0 0 0 0 3 0 5 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Wild oat 0  0 0 0  0 0  --                                                                              0  0 0 0 0 0 0 0 0  0 0       0                                                                             0                                                                             0                                                                             --                                                                              --                  Barnyardgrass                                                                          9  9 9 10 8 9  9 9  9 9 9 7 9 6 9 9  7 7       9                                                                             0                                                                             9                                                                             8 8                   Rice Japonica                                                                          0  0 0 0  3 5  6 0  0 0 0 0 0 1 3 0  0 0       0                                                                             0                                                                             0                                                                             1 0                   Umbrella sedge                                                                         9  9 9 0  9 8  8 0  0 8 8 0 0 6 7 0  0 0       7                                                                             0                                                                             0                                                                             0 0                   __________________________________________________________________________             Rate                                                                          (500 g/ha)                                                                          (250 g/ha)                 (125 g/ha)                                   COMPOUND                                                                      40 41 25 26 27 28 29 36 40 41 43 25 26                                                                              27 28 29                                                                              36 40                                                                              41                __________________________________________________________________________    PREEMERGENCE                                                                  Barley Igri                                                                            5  3  0  0  0  0  0  0  2  1  2  0  0 0  0  0 0  0 0                 Bedstraw -- -- 0  4  3  0  3  7  2  -- 9  0  0 0  0  0 5  0  0                Blackgrass                                                                             10 10 10 8  8  10 7  10 10 10 10 10 7 7  10 5 10 10 10               Chickweed                                                                              9  7  6  8  8  7  5  9  9  7  9  4  7 7  6  3 0  4  5                Corn     2  9  2  0  2  2  0  2  0  6  6  0  0 0  0  0 0  0  2                Cotton   0  2  0  3  0  0  0  0  0  2  7  0  2 0  0  0 0  0  0                Crabgrass                                                                              10 10 10 9  10 10 10 10 10 10 10 9  8 10 10 8 8  8  10               Downy brome                                                                            9  7  3  0  3  6  0  4  9  6  6  0  0 2  5  0 0  4  4                Duck salad                                                                             -- -- -- -- -- -- -- -- -- -- -- -- --                                                                              -- -- --                                                                              -- -- --               Giant foxtail                                                                          9  10 10 9  9  10 9  10 7  10 10 9  9 8  10 9 8  6  10               Lambsquarters                                                                          9  9  7  8  6  7  0  8  9  9  9  5  3 5  6  0 4  -- 8                Morningglory                                                                           0  0  3  0  2  2  0  6  0  0  0  2  0 0  2  0 4  0  0                Pigweed  7  9  0  0  7  6  7  4  4  8  7  0  0 2  3  5 1  4  8                Rape     0  6  0  0  0  0  0  3  0  5  0  0  0 0  0  0 0  0  4                Ryegrass 10 10 10 10 6  10 6  9  10 9  10 7  7 5  10 4 9  8  7                Sorghum  5  4  4  2  5  4  0  6  4  2  3  2  0 3  2  0 4  1  2                Soybean  0  4  2  -- 0  0  -- 0  0  0  4  0  --                                                                              0  0  0 0  0  0                Speedwell                                                                              9  8  5  7  6  7  3  6  9  8  6  3  3 2  5  0 5  4  5                Sugar beet                                                                             9  7  0  0  4  4  3  6  6  7  4  0  0 3  3  2 3  0  3                Velvetleaf                                                                             5  8  5  8  3  7  4  5  2  8  8  2  3 2  5  2 3  2  7                Wheat    5  2  3  0  3  0  3  0  0  2  5  3  0 0  0  0 0  0  0                Wild buckwheat                                                                         -- 9  0  5  6  5  3  9  0  9  8  0  3 4  3  0 5  0  5                Wild oat 4  5  0  3  3  6  3  5  4  5  5  0  0 0  4  0 3  4  3                Barnyardgrass                                                                          -- -- -- -- -- -- -- -- -- -- -- -- --                                                                              -- -- --                                                                              -- -- --               Rice Japonica                                                                          -- -- -- -- -- -- -- -- -- -- -- -- --                                                                              -- -- --                                                                              -- -- --               Umbrella sedge                                                                         -- -- -- -- -- -- -- -- -- -- -- -- --                                                                              -- -- --                                                                              -- -- --               __________________________________________________________________________             Rate                                                                          (62 g/ha)          (31 g/ha)       (16 g/ha)      (4 g/ha)                    COMPOUND                                                                      25                                                                              26                                                                              27                                                                              28 29                                                                              36                                                                              40                                                                              41                                                                              43                                                                              25                                                                              26                                                                              27                                                                              28                                                                              29                                                                              36                                                                              40                                                                              41                                                                              25                                                                              26                                                                              27                                                                              28                                                                              29                                                                              36 43                                                                             43                  __________________________________________________________________________    PREEMERGENCE                                                                  Barley Igri                                                                            0 0 0 0  0 0  0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0                  Bedstraw 0 0 0 0  0 2  0 0 2 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Blackgrass                                                                             8 4 6 8  4 10 8 10                                                                              6 6 3 4 5 3 5 1 9 3       0                                                                             3                                                                             4                                                                             3 4 0 0                  Chickweed                                                                              3 4 6 5  2 0  0 5 2 0 0 4 4 0 0 0 2 0       0                                                                             0                                                                             3                                                                             0 0 0 0                  Corn     0 0 0 0  0 0  0 0 3 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Cotton   0 0 0 0  0 0  0 0 4 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Crabgrass                                                                              9 5 9 10 8 8  6 10                                                                              9 8 --                                                                              8 9 5 7 2 9 6       2                                                                             5                                                                             7                                                                             5 5 5 0                  Downy brome                                                                            0 0 0 3  0 0  4 0 4 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Duck salad                                                                             --                                                                              --                                                                              --                                                                              -- --                                                                              -- --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --      --                                                                            --                                                                            --                                                                            --                                                                              --                                                                              --                                                                              --                 Giant foxtail                                                                          8 6 7 10 8 7  3 10                                                                              8 6 4 7 8 6 7 0 8 4       2                                                                             5                                                                             5                                                                             5 3 4 0                  Lambsquarters                                                                          4 3 4 2  0 4  --                                                                              8 8 3 3 3 0 0 2 8 7 0       3                                                                             0                                                                             0                                                                             0 0 7 0                  Morningglory                                                                           0 0 0 0  0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Pigweed  0 0 2 0  2 0  2 6 3 0 0 0 0 0 0 2 4 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Rape     0 0 0 0  0 0  0 4 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Ryegrass 6 4 4 6  3 2  8 3 4 4 3 4 4 0 0 0 3 3       0                                                                             3                                                                             3                                                                             0 0 3 0                  Sorghum  0 0 2 0  0 2  0 0 0 0 0 0 0 0 2 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Soybean  0 0 0 0  0 0  0 0 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Speedwell                                                                              0 0 0 3  0 2  0 3 6 0 0 0 0 0 3 0 0 0       0                                                                             0                                                                             0                                                                             0 0 2 0                  Sugar beet                                                                             0 0 0 0  0 3  0 2 4 0 0 0 0 0 3 0 0 0       0                                                                             0                                                                             0                                                                             0 0 2 0                  Velvetleaf                                                                             0 2 0 2  2 3  0 5 6 0 0 0 0 0 3 0 3 0       0                                                                             0                                                                             0                                                                             0 0 3 0                  Wheat    0 0 0 0  0 0  0 0 2 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Wild buckwheat                                                                         0 0 4 0  0 4  0 3 0 0 0 3 0 0 --                                                                              0 0 0       0                                                                             3                                                                             0                                                                             0 --                                                                              0 0                  Wild oat 0 0 0 0  0 0  0 2 0 0 0 0 0 0 0 0 0 0       0                                                                             0                                                                             0                                                                             0 0 0 0                  Barnyardgrass                                                                          --                                                                              --                                                                              --                                                                              -- --                                                                              -- --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --      --                                                                            --                                                                            --                                                                            --                                                                              --                                                                              --                                                                              --                 Rice Japonica                                                                          --                                                                              --                                                                              --                                                                              -- --                                                                              -- --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --      --                                                                            --                                                                            --                                                                            --                                                                              --                                                                              --                                                                              --                 Umbrella sedge                                                                         --                                                                              --                                                                              --                                                                              -- --                                                                              -- --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --                                                                              --      --                                                                            --                                                                            --                                                                            --                                                                              --                                                                              --                                                                              --                 __________________________________________________________________________

TEST C

Plastic pots were partially filled with silt loam soil. The soil wasthen saturated with water. Japonica rice (Oryza sativa) seedlings at the2.0 to 2.5 leaf stage, seeds selected from barnyardgrass (Echinochloacrus-galli), duck salad (Heteranthera limosa), umbrella sedge (Cyperusdifformis), and tubers selected from arrowhead (Sagittaria spp.), andwaterchestnut (Eleocharis spp.), were planted into this soil. Afterplanting, water levels were raised to 3 cm above the soil surface andmaintained at this level throughout the test. The compounds indicatedwere formulated in a non-phytotoxic solvent and applied directly to thepaddy water. Treated plants and controls were maintained in a greenhousefor approximately 21 days, after which all species were compared tocontrols and visually evaluated. Plant response ratings, summarized inTable C, are reported on a 0 to 10 scale where 0 is no effect and 10 iscomplete control. A dash (-) response means no test result.

                                      TABLE C                                     __________________________________________________________________________             Rate (500 g/ha)                                                                        Rate (250 g/ha)                                                                        Rate (125 g/ha)                                                                       Rate (64 g/ha)                                                                         Rate (32 g/ha)                             COMPOUND                                                                      25 27 28 25 27 28 25                                                                              27 28 25                                                                              27 28  25  27                                                                              28                          __________________________________________________________________________    PADDY                                                                         Arrowhead                                                                              -- 8  8  -- 6  5  --                                                                              3  2  --                                                                              0  1   --  0 0                           Barnyardgrass                                                                          10 10 10 8  10 10 7 10 10 7 7  9   5   6 8                           Duck salad                                                                             10 -- 10 10 -- 10 6 -- 10 4 -- 10  0   --                                                                              9                           Japonica rice                                                                          1  4  2  1  3  4  0 1  1  0 0  0   0   0 0                           Umbrella sedge                                                                         8  9  9  9  9  9  8 9  9  7 8  9   0   7 8                           Waterchestnut                                                                          3  3  7  3  3  7  0 2  4  0 0  1   0   0 0                           __________________________________________________________________________

TEST D

Plastic pots were partially filled with silt loam soil. The soil wasthen flooded with water, Japonica rice (Oryza sativa) sprouted seeds and1.5 leaf transplants were planted in the soil. Seeds of barnyardgrass(Echinochloa crus-galli) were planted in saturated soil and plants grownto the 1 leaf, 2 leaf and 3 leaf stages for testing. At testing, thewater level for all plantings was raised to 2 cm above the soil surface.The compounds indicated were formulated in a non-phytotoxic solvent andapplied directly to the paddy water. Treated plants and controls weremaintained in a greenhouse for approximately 21 days, after which allspecies were compared to controls and visually evaluated. Plant responseratings, summarized in Table D are reported on a 0 to 10 scale where 0is no effect and 10 is complete control. A dash (-) response means notest result.

                  TABLE D                                                         ______________________________________                                                   COMPOUND                                                           Rate (1000 g/ha)                                                                           26    27     28  29   36                                         ______________________________________                                        PADDY                                                                         1-LF B.Y.Grass                                                                             10    10     10  10   10                                         2-LF B.Y.Grass                                                                             10    10     10  10   10                                         3-lf B.Y.Grass                                                                             10    10     10  10    9                                         Jap Direct Seed                                                                             9     9      9   7    9                                         Jap Rice Eff  6     8      5   3    0                                         ______________________________________                                                   COMPOUND                                                           Rate (500 g/ha)                                                                            25    26     27  28   29  36   43                                ______________________________________                                        PADDY                                                                         1-LF B.Y.Grass                                                                             10    10     10  10   10  10   --                                2-LF B.Y.Grass                                                                             10    10     10  10    9   9   10                                3-lf B.Y.Grass                                                                              9     9     10  10   10   8   10                                Jap Direct Seed                                                                             6     7      8   8    6   6   10                                Jap Rice Eff  4     2      5   5    0   0    4                                ______________________________________                                                   COMPOUND                                                           Rate (250 g/ha)                                                                            25    26     27  28   29  36   43                                ______________________________________                                        PADDY                                                                         1-LF B.Y.Grass                                                                             10    10     10  10   10  10   --                                2-LF B.Y.Grass                                                                              9    10     10  10   10   9   10                                3-lf B.Y.Grass                                                                              8     9     10  10   10   7   10                                Jap Direct Seed                                                                             4     7      5   5    4   5   10                                Jap Rice Eff  5     2      0   3    0   0    2                                ______________________________________                                                   COMPOUND                                                           Rate (125 g/ha)                                                                            25    26     27  28   29  36   41  43                            ______________________________________                                        PADDY                                                                         1-LF B.Y.Grass                                                                              9    10     10  10   10  10   --  --                            2-LF B.Y.Grass                                                                              6     6     10  10    9   9    8  10                            3-lf B.Y.Grass                                                                              6     6      9  10    7   7    9   9                            Jap Direct Seed                                                                             2     2      1   2    2   1    8   8                            Jap Rice Eff  0     0      1   0    0   0    1   2                            ______________________________________                                                   COMPOUND                                                           Rate (64 g/ha)                                                                             25    26     27  28   29   36  41  43                            ______________________________________                                        PADDY                                                                         1-LF B.Y.Grass                                                                              9     9     10  10    9  10   --  --                            2-LF B.Y.Grass                                                                              8     5      9   8    9   8    8   9                            3-lf B.Y.Grass                                                                              4     4      7   8    7   5    7   7                            Jap Direct Seed                                                                             5     0      1   1    1   0    7   7                            Jap Rice Eff  0     0      0   0    0   0    0   0                            ______________________________________                                                   COMPOUND                                                           Rate (32 g/ha)                                                                             25     41    43                                                  ______________________________________                                        PADDY                                                                         1-LF B.Y.Grass                                                                              9     --    --                                                  2-LF B.Y.Grass                                                                              3      4     8                                                  3-lf B.Y.Grass                                                                              2      3     6                                                  Jap Direct Seed                                                                             0      0     5                                                  Jap Rice Eff  0      0     1                                                  ______________________________________                                                   COMPOUND                                                           Rate (16 g/ha)                                                                             41                                                               ______________________________________                                        PADDY                                                                         2-LF B.Y.Grass                                                                              3                                                               3-lf B.Y.Grass                                                                              0                                                               Jap Direct Seed                                                                             0                                                               Jap Rice Eff  1                                                               ______________________________________                                                   COMPOUND                                                           Rate (8 g/ha)                                                                              41                                                               PADDY                                                                         2-LF B.Y.Grass                                                                              0                                                               3-lf B.Y.Grass                                                                              0                                                               Jap Direct Seed                                                                             0                                                               Jap Rice Eff  0                                                               ______________________________________                                    

TEST E

Seeds of barnyardgrass (Echinochloa crus-galli), corn (Zea mays), cotton(Gossypium hirsutam), crabgrass (Digitaria spp.), fall panicum (Panicumdicholomiflorum), giant foxtail (Setaria faberii), green foxtail(Setaria vividis), johnson grass (Sorghum halepense), signalgrass(Brachiaria platyphylla), soybean (Glycine max) and wild proso (Panciummiliaceum) were planted into a silt loam soil. The compounds indicatedwere dissolved in a non-phytotoxic solvent, and then applied to the soilsurface within one day after the seeds were planted.

Treated plants and untreated controls were maintained in the greenhouseapproximately 21 days, then treated plants were compared to untreatedcontrols and visually evaluated. Plant response ratings, summarized inTable E, are reported on a 0 to 10 scale where 0 is no effect and 10 iscomplete control.

                  TABLE E                                                         ______________________________________                                                  COM-                COM-                                                      POUND               POUND                                           ______________________________________                                        Rate (500 g/ha)                                                                           28        Rate (250 g/ha)                                                                           28                                          PRE-                  PRE-                                                    EMERGENCE             EMERGENCE                                               Barnyardgrass                                                                             10        Green Foxtail                                                                             10                                          Corn         6        Johnson Grass                                                                             8                                           Cotton       0        Signalgrass 10                                          Crabgrass   10        Soybean     0                                           Fall Panicum                                                                              10        Wild Proso  10                                          Giant Foxtail                                                                             10        Rate (125 g/ha)                                                                           28                                          Green Foxtail                                                                             10        PRE-                                                    Johnson Grass                                                                              9        EMERGENCE                                               Signalgrass 10        Barnyardgrass                                                                             10                                          Soybean      1        Corn        2                                           Wild Proso  10        Cotton      0                                           Rate (250 g/ha)                                                                           28        Crabgrass   8                                           PRE-                  Fall Panicum                                                                              10                                          EMERGENCE             Giant Foxtail                                                                             10                                          Barnyardgrass                                                                             10        Green Foxtail                                                                             8                                           Corn         5        Johnson Grass                                                                             7                                           Cotton       0        Signalgrass 10                                          Crabgrass   10        Soybean     0                                           Fall Panicum                                                                              10        Wild Proso  9                                           Giant Foxtail                                                                             10                                                                Rate (62 g/ha)                                                                            28        Rate (31 g/ha)                                                                            28                                          PRE-                  PRE-                                                    EMERGENCE             EMERGENCE                                               Barnyardgrass                                                                             10        Barnyardgrass                                                                             10                                          Corn         1        Corn        0                                           Cotton       0        Cotton      0                                           Crabgrass    7        Crabgrass   6                                           Fall Panicum                                                                              10        Fall Panicum                                                                              8                                           Giant Foxtail                                                                              8        Giant Foxtail                                                                             8                                           Green Foxtail                                                                              6        Green Foxtail                                                                             4                                           Johnson Grass                                                                              2        Johnson Grass                                                                             0                                           Signalgrass  9        Signalgrass 9                                           Soybean      0        Soybean     0                                           Wild Proso   9        Wild Proso  9                                           ______________________________________                                    

TEST F

Compounds evaluated in this test were formulated in a non-phytoxicsolvent and applied to the soil surface before plant seedlings emerged(preemergence application) and to plants that were in the one-to-fourleaf stage (postemergence application). A sandy loam soil was used forthe preemergence test while a mixture of sandy loam soil and greenhousepotting mix in a 60:40 ratio was used for the postemergence test. Testcompounds were applied within approximately one day after planting seedsfor the preemergence test. Plantings of these crops and weed specieswere adjusted to produce plants of appropriate size for thepostemergence test. All plant species were grown using normal greenhousepractices. Crop and weed species include winter barley (Hordeum vulgarecv. `Igri`), blackgrass (Alopecurus myosuroides), chickweed (Stellariamedia), downy brome (Bromus tectorum), field violet (Viola aryensis),galium (Galium aparine), green foxtail (Setaria viridis), kochia (Kochiascoparia), lambsquarters (Chenopodium album), Persian speedwell(Veronica persica), rape (Brassica napus cv. `Jet Neuf`), ryegrass(Lolium multiflorum), sugar beet (Beta vulgaris cv. `US 1`), sunflower(Helianthus annuus cv. `Russian Giant`), spring wheat (Triticum aestivumcv. `ERA`), winter wheat (Triticum aestivum cv. `Talent`), wildbuckwheat (Polygonum convolvulus), wild mustard (Sinapis arvensis), wildoat (Avena fatua), and wild radish (Raphanus raphanistrum). Blackgrassand wild oat were treated postemergence at two growth stages. The firststage (1) was when the plants had two to three leaves. The second stage(2) was when the plants had approximately four leaves or in the initialstages of tillering. Treated plants and untreated controls weremaintained in a greenhouse for approximately 21 to 28 days, after whichall treated plants were compared to untreated controls and visuallyevaluated. Plant response ratings, summarized in Table F, are based upona 0 to 10 scale where 0 is no effect and 10 is complete control. A dashresponse (-) means no test result.

                  TABLE F                                                         ______________________________________                                                   COM-                    COM-                                                  POUND                   POUND                                      ______________________________________                                        Rate (500 g/ha)                                                                          41         Rate (500 g/ha)                                                                            41                                         POST-                 PRE-                                                    EMERGENCE             EMERGENCE                                               Blackgrass (1)                                                                           5          Blackgrass (1)                                                                             9                                          Blackgrass (2)                                                                           5          Blackgrass (2)                                                                             8                                          Chickweed  3          Chickweed    9                                          Downy brome                                                                              0          Downy brome  4                                          Field violet                                                                             4          Field violet 9                                          Galium (1) 3          Galium (1)   8                                          Galium (2) 3          Galium (2)   8                                          Green foxtail                                                                            0          Green foxtail                                                                              10                                         Kochia     4          Kochia       10                                         Lambsquarters                                                                            5          Lambsquarters                                                                              --                                         Persn Speedwell                                                                          2          Persn Speedwell                                                                            7                                          Rape       0          Rape         6                                          Ryegrass   2          Ryegrass     10                                         Sugar beet 4          Sugar beet   8                                          Sunflower  2          Sunflower    2                                          Wheat (Spring)                                                                           3          Wheat (Spring)                                                                             3                                          Wheat (Winter)                                                                           2          Wheat (Winter)                                                                             2                                          Wild buckwheat                                                                           5          Wild buckwheat                                                                             8                                          Wild mustard                                                                             3          Wild mustard 5                                          Wild oat (1)                                                                             2          Wild oat (1) 5                                          Wild oat (2)                                                                             2          Wild oat (2) 6                                          Wild radish                                                                              0          Wild radish  2                                          Winter Barley                                                                            2          Winter Barley                                                                              3                                          ______________________________________                                                   COM-                    COM-                                                  POUND                   POUND                                      ______________________________________                                        Rate (250 g/ha)                                                                          41         Rate (250 g/ha)                                                                            41                                         POST-                 PRE-                                                    EMERGENCE             EMERGENCE                                               Blackgrass (1)                                                                           3          Blackgrass (1)                                                                             7                                          Blackgrass (2)                                                                           3          Blackgrass (2)                                                                             6                                          Chickweed  2          Chickweed    7                                          Downy brome                                                                              0          Downy brome  0                                          Field violet                                                                             2          Field violet 7                                          Galium (1) 0          Galium (1)   6                                          Galium (2) 0          Galium (2)   5                                          Green foxtail                                                                            0          Green foxtail                                                                              10                                         Kochia     2          Kochia       7                                          Lambsquarters                                                                            3          Lambsquarters                                                                              --                                         Persn Speedwell                                                                          0          Persn Speedwell                                                                            5                                          Rape       0          Rape         4                                          Ryegrass   0          Ryegrass     8                                          Sugar beet 2          Sugar beet   6                                          Sunflower  0          Sunflower    0                                          Wheat (Spring)                                                                           0          Wheat (Spring)                                                                             0                                          Wheat (Winter)                                                                           0          Wheat (Winter)                                                                             0                                          Wild buckwheat                                                                           4          Wild buckwheat                                                                             6                                          Wild mustard                                                                             0          Wild mustard 4                                          Wild oat (1)                                                                             0          Wild oat (1) 2                                          Wild oat (2)                                                                             0          Wild oat (2) 3                                          Wild radish                                                                              0          Wild radish  0                                          Winter Barley                                                                            0          Winter Barley                                                                              0                                          ______________________________________                                                   COM-                    COM-                                                  POUND                   POUND                                      ______________________________________                                        Rate (125 g/ha)                                                                          41         Rate (64 g/ha)                                                                             41                                         POST-                 POST-                                                   EMERGENCE             EMERGENCE                                               Blackgrass (1)                                                                           0          Blackgrass (1)                                                                             0                                          Blackgrass (2)                                                                           0          Blackgrass (2)                                                                             0                                          Chickweed  0          Chickweed    0                                          Downy brome                                                                              0          Downy brome  0                                          Field violet                                                                             0          Field violet 0                                          Galium (1) 0          Galium (1)   0                                          Galium (2) 0          Galium (2)   0                                          Green foxtail                                                                            0          Green foxtail                                                                              0                                          Kochia     0          Kochia       0                                          Lambsquarters                                                                            2          Lambsquarters                                                                              0                                          Persn Speedwell                                                                          0          Persn Speedwell                                                                            0                                          Rape       0          Rape         0                                          Ryegrass   0          Ryegrass     0                                          Sugar beet 0          Sugar beet   0                                          Sunflower  0          Sunflower    0                                          Wheat (Spring)                                                                           0          Wheat (Spring)                                                                             0                                          Wheat (Winter)                                                                           0          Wheat (Winter)                                                                             0                                          Wild buckwheat                                                                           2          Wild buckwheat                                                                             0                                          Wild mustard                                                                             0          Wild mustard 0                                          Wild oat (1)                                                                             0          Wild oat (1) 0                                          Wild oat (2)                                                                             0          Wild oat (2) 0                                          Wild radish                                                                              0          Wild radish  0                                          Winter Barley                                                                            0          Winter Barley                                                                              0                                          ______________________________________                                                   COM-                    COM-                                                  POUND                   POUND                                      ______________________________________                                        Rate (64 g/ha)                                                                           41         Rate (32 g/ha)                                                                             41                                         PRE-                  POST-                                                   EMERGENCE             EMERGENCE                                               Blackgrass (1)                                                                           2          Blackgrass (1)                                                                             0                                          Blackgrass (2)                                                                           3          Blackgrass (2)                                                                             0                                          Chickweed  3          Chickweed    0                                          Downy brome                                                                              0          Downy brome  0                                          Field violet                                                                             3          Field violet 0                                          Galium (1) 2          Galium (1)   0                                          Galium (2) 2          Galium (2)   0                                          Green foxtail                                                                            7          Green foxtail                                                                              0                                          Kochia     2          Kochia       0                                          Lambsquarters                                                                            --         Lambsquarters                                                                              0                                          Persn Speedwell                                                                          3          Persn Speedwell                                                                            0                                          Rape       2          Rape         0                                          Ryegrass   4          Ryegrass     0                                          Sugar beet 3          Sugar beet   0                                          Sunflower  0          Sunflower    0                                          Wheat (Spring)                                                                           0          Wheat (Spring)                                                                             0                                          Wheat (Winter)                                                                           0          Wheat (Winter)                                                                             0                                          Wild buckwheat                                                                           2          Wild buckwheat                                                                             0                                          Wild mustard                                                                             0          Wild mustard 0                                          Wild oat (1)                                                                             0          Wild oat (1) 0                                          Wild oat (2)                                                                             0          Wild oat (2) 0                                          Wild radish                                                                              0          Wild radish  0                                          Winter Barley                                                                            0          Winter Barley                                                                              0                                          ______________________________________                                                   COM-                    COM-                                                  POUND                   POUND                                      ______________________________________                                        Rate (32 g/ha)                                                                           41         Rate (16 g/ha)                                                                             41                                         PRE-                  POST-                                                   EMERGENCE             EMERGENCE                                               Blackgrass (1)                                                                           0          Blackgrass (1)                                                                             0                                          Blackgrass (2)                                                                           0          Blackgrass (2)                                                                             0                                          Chickweed  0          Chickweed    0                                          Downy brome                                                                              0          Downy brome  0                                          Field violet                                                                             0          Field violet 0                                          Galium (1) 0          Galium (1)   0                                          Galium (2) 0          Galium (2)   0                                          Green foxtail                                                                            3          Green foxtail                                                                              0                                          Kochia     0          Kochia       0                                          Lambsquarters                                                                            --         Lambsquarters                                                                              0                                          Persn Speedwell                                                                          0          Persn Speedwell                                                                            0                                          Rape       0          Rape         0                                          Ryegrass   0          Ryegrass     0                                          Sugar beet 0          Sugar beet   0                                          Sunflower  0          Sunflower    0                                          Wheat (Spring)                                                                           0          Wheat (Spring)                                                                             0                                          Wheat (Winter)                                                                           0          Wheat (Winter)                                                                             0                                          Wild buckwheat                                                                           0          Wild buckwheat                                                                             0                                          Wild mustard                                                                             0          Wild mustard 0                                          Wild oat (1)                                                                             0          Wild oat (1) 0                                          Wild oat (2)                                                                             0          Wild oat (2) 0                                          Wild radish                                                                              0          Wild radish  0                                          Winter Barley                                                                            0          Winter Barley                                                                              0                                          ______________________________________                                                   COM-                                                                          POUND                                                              ______________________________________                                        Rate (16 g/ha)                                                                           41                                                                 PRE-                                                                          EMERGENCE                                                                     Blackgrass (1)                                                                           0                                                                  Blackgrass (2)                                                                           0                                                                  Chickweed  0                                                                  Downy brome                                                                              0                                                                  Field violet                                                                             0                                                                  Galium (1) 0                                                                  Galium (2) 0                                                                  Green foxtail                                                                            0                                                                  Kochia     0                                                                  Lambsquarters                                                                 Persn Speedwell                                                                          0                                                                  Rape       0                                                                  Ryegrass   0                                                                  Sugar beet 0                                                                  Sunflower  0                                                                  Wheat (Spring)                                                                           0                                                                  Wheat (Winter)                                                                           0                                                                  Wild buckwheat                                                                           0                                                                  Wild mustard                                                                             0                                                                  Wild oat (1)                                                                             0                                                                  Wild oat (2)                                                                             0                                                                  Wild radish                                                                              0                                                                  Winter Barley                                                                            0                                                                  ______________________________________                                    

What is claimed is:
 1. A compound of Formulae III through VI andstereoisomers thereof ##STR17## wherein n is 2, 3 or 4;m is 3, 4 or 5;R¹ is straight chain C₁ -C₃ alkyl; R² is H, C₁ -C₄ alkyl, C₂ -C₄ alkenylor C₂ -C₄ alkynyl; R³ is R⁴ are independently H, C₁ -C₄ alkyl, C₂ -C₄alkenyl, C₂ -C₄ alkynyl or C₁ -C₃ alkyl substituted with OCH₃ or OCH₂CH₃ ; R⁵ and R⁶ are independently H, OCH₃ or C₁ -C₂ alkyl; Q is CH₂ W or##STR18## q and r are independently 0-2; R⁷ is H, halogen, C₁ -C₃ alkyl,OR⁸, SR⁸ or CN; R⁸ is C₁ -C₃ alkyl or C₁ -C₃ haloalkyl; Z is CH₂, NR⁹,O, S or may be CH and taken to form a double bond with an adjacentcarbon; R⁹ is H or C₁ -C₃ alkyl; W is phenyl optionally substituted with1-3 substituents selected from halogen, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, OH,CN, C₁ -C₃ haloalkyl, C₁ -C₃ haloalkoxy, C₁ -C₃ alkylthio, C₂ -C₄alkenyl and C₂ -C₄ alkynyl; or W is 5-, 6- or 7-membered heterocyclicring containing 0-2 nitrogens, 0-2 oxygens or 0-2 sulfurs, each ringoptionally substituted with 1-2 substituents selected from halogen, CH₃and OCH₃ ;provided that 1) the sum of q and r i s 0-2; 2) if the sum ofq and r is 0 then Z is CH₂ ; and 3) if W is a heterocycle then the totalnumber of heteroatoms contained within the heterocyclic rings is 3 orless.
 2. Compounds of claim 1 wherein the formulas are selected from IIIand V andW is phenyl optionally substituted by 1-2 substituents selectedfrom F, Cl, Br, CH₃ and OCH₃ ; or W is tetrahydropyran, tetrahydrofuran,thiophene, isoxazole, pyridine or pyrazine, each ring optionallysubstituted with 1-2 substituents selected from F, Cl, Br, CH₃ and OCH₃; Q is CH₂ W or ##STR19## R⁵ and R⁶ are independently H or C₁ -C₂ alkyl.3. Compounds of claim 2 selected from formulas III and V wherein:R² isH, C₁ -C₃ alkyl, C₂ -C₃ alkenyl or C₂ -C₃ alkynyl.
 4. Compounds of claim3 selected from formula III and V wherein:R³ is H, C₁ -C₃ alkyl, C₃ -C₄alkenyl or C₃ -C₄ alkynyl; R⁴ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃-C₄ alkynyl.
 5. Compounds of claim 4 selected from formula III and Vwherein:Q is CH₂ W or Q-1, Q-3, Q-4, Q-6, Q-7, Q-8 or Q-15; R⁵ and R⁶are independently H; W is phenyl optionally substituted with 1-2substituents selected from F, Cl, Br and CH₃ ; tetrahydrofuran;thiophene optionally substituted with Cl or Br; or pyridine. 6.Compounds of claim 5 selected from formula III and V wherein:R¹ is CH₃or CH₂ CH₃ ; R² is H, CH₃, CH₂ CH₃ or allyl; and R³ and R⁴ are H. 7.Compounds of claim 6 wherein the Formula is Formula V.
 8. A compound ofclaim 1 selected from the group consistingof:(2α,3β,4aβ,5α,7aβ)-3-[(2-fluorophenyl)methoxy]-octahydro-2,4a-dimethyl-2,5-methanocyclopenta[b]pyran,(2α,3β,4aβ,5α,9aβ)-3-[(2,6-difluorophenyl)-methoxy]decahydro-2-methyl-2,5-methanocyclohepta-[b]pyran,(2α,3β,4aβ,5α,7aβ)-3-[(2-fluorophenyl)-methoxy]octahydro-2-methyl-2,5-methanocyclopenta-[b]pyran,(2α,3β,4aβ,5α,9aβ)-3-[(2-fluorophenyl)-methoxy]decahydro-2-methyl-2,5-methanocyclohepta-[b]pyran,(2α,3β,4aβ,5α,7aβ)-octahydro-2,4a-dimethyl-3-(phenylmethoxy)-2,5-methanocyclopenta[b]-pyran,(2α,3β,4aβ,5α,7aβ)-3-[(2-chlorophenyl)methoxy]octahydro-2,4a-dimethyl-2,5-methanocyclopenta[b]pyranand(2α,3β,4aβ,5α,7aβ)-octahydro-2,4a-dimethyl-3-[(2-methylphenyl)methoxy]-2,5-methanocyclopenta[b]pyran.9. An agriculturally suitable composition for controlling the growth ofundesired vegetation comprising an effective amount of the compound ofclaim 1 and at least one of the following: surfactant, solid diluent orliquid diluent.
 10. A method for controlling the growth of undesiredvegetation which comprises applying to the locus to be protected aneffective amount of a compound of claim 1.